Folate Metabolism (Homo sapiens)

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22, 27019, 116, 161, 197, 204...26, 29410, 25, 116, 249, 2832492133052, 278167, 298233124181, 27388145, 186, 266EnzymesReactionOverarching processLipid peroxidationCleavageProtein tyrosine nitrationLipoprotein melabolismCatalysisProtein with polymorphismCofactor conversionMicronutrientsLEGENDTranscription factorFrom intracellular part to the plasmaGlycogenesisis composed ofOther proteinsSelenoproteinsInhibitionCofactorsProcess or metabolism involved in Se PathwaySelenium statusBindingConversionProtein*StimulationNegative EffectBiomarker forNecessary stimulationMetabolitesProstaglandins metabolismIntracellularNovo purine biosynthetic pathwayMethylation reactionsDNA oxidationApoptosisPlasma8-Isoprostaglandin F2aThromboxane B2PGE1PGF2aPGE2SLC19A1Thromboxane B2FOLR48-Isoprostaglandin F2ap53PGE2F2-IsoprostaneRELAPGF2aThromboxane A2PGE1NFkB1MCP1NFkB2FOLR3FOLR1MCP1F2-IsoprostaneFOLR2SLC46A110, 88, 95, 186, 257...90, 141292453289111241, 90, 29232811, 9011290, 14111, 90453282924, 6491916491328MTHFD1*SHMTMTR*MSR*AHCYMATMTHFD2DHFR8857254, 273123, 1442733, 144, 268, 3271, 275, 286133, 273CBS3, 143NADP+NADP+NADP+NADP+NADP+NADP+NADP+NOSMPOCatalaseMPO25, 114, 160, 200249, 29725, 114, 160, 2004CysteineCysteineThrombinPAI-1tPAtPAFactor VIIPLGPLGPAI-1Factor VIIThrombin183, 30946464646227, 30946227, 30946183, 309GPX 4H2O25-Formyl-THFDihydrofolate5,10-Methylene-THFFGARGAR(11R)-hydroxymethylene-THF5,10-Methenyl-THF10-Formyl-THF(11S)-hydroxymethylene-THF273273273181, 273286273, 286273181, 273273Folate5-methyl-THF5-methyl-THFFolate286, 3272866, 22, 28, 45, 88...SOD3SOD3RFK255H2OGPX 3GPX 3CTH3Heme143, 249, 297THF286NADPHNADPHNADPHNADPHNADPHNADPHNADPHGPX 6ManganeseManganeseFolic acidFolic acid86, 268, 28686, 268, 286GPX 2GPX 1RNS21, 249GARTSHMTMTHFR*MTHFS268, 286181, 273273273HomocysteineHomocysteine19, 45, 99, 116, 227...227SOD1Pyridoxal 5'-phosphatePyridoxal 5'-phosphate4, 168, 313168, 313GlycineGlycineSerineL-Arginine133, 273133, 273133, 273272ACTHDL/SAAHDLAPOBAPOA1-NO2TyrSAA2oxLDLVLDL-TAGVLDL-TAGLDLACTFMNVLDLSAA4oxLDLCholesterolHDL/APOA1TAGAPOA1VLDL/APOBAPOBSAA3SRB1TAGVLDLLDLHDL-CAPOA1LDLRABCA1SAA1CholesterolHDLHDL-C18, 442784497, 1152781657, 28, 52, 200, 30744278977, 52, 200, 30728, 278278242, 278173278242, 2784420, 242, 27844242, 278242, 27828, 278447, 52, 200, 3074420, 2787, 28, 52, 200, 3072782027818, 444497, 115O2298Cob(II)alaminFADCob(I)alamin8-OHdG8-OHdGFADCob(I)alamin123, 144, 241123, 144, 241144123, 144165124124ADPADPMagnesiumChlorineChlorineMagnesiumCystathionineS-nitrosohomocysteine99SOD2Serine133, 273ATPZincZincHNO2NONO2HOClNOO3114, 16099, 114, 160, 186IL10INSALBFibrinHBA1HbA1cIL4IFNgIL10INSIL6IFNgD-dimerIL1BTNFaTNFaCSF1IL6IL1BD-dimerFibrinogenHBBFibrinIL2IL4sICAM-1HbA1cFibrinogenCSF1CRPINSRIL2ALB46, 21619, 154, 20326018, 224, 23321846, 18359224, 32631018, 224, 23332822, 69116, 271328959522, 6995, 204116, 154, 224, 3105959197, 32526069, 116, 197, 32546, 18321827146, 21616195, 204154, 1614, 6, 7, 154, 167...59Riboflavin38O2Methionine S-Adenosylhomocysteine S-AdenosylmethionineMethionine S-Adenosylhomocysteine S-Adenosylmethionine80, 28627980, 286279, 286, 32788, 144, 184, 286144, 184, 286ADPNitrotyrosineNitrotyrosineTetrahydrobiopterinONOO/ONOOH2127221ATPATPFructosamineFructosamineGlucoseGlucose26059, 23359, 233260IronIron4242FLAD1126, 255