Acetylcholine Synthesis (Mus musculus)

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1*Cytosol**Synaptic Cleft*ChatCholinePdha1Pdha2CholinePemtPcyt1aPhosphatidylethanolamineAchePhosphorylcholineAcetylcholineAcetateChkaPhosphatidylcholineAcetyl-CoAPyruvate from GlycolysisGlycerophosphocholineCytidine diphosphate choline


Acetylcholine is an important neurotransmitter. It can be rapidly released in the synaptic cleft upon activation of the neuron. In the synaptic cleft the compound is degraded rapidly into choline and acetate, this is essential for proper neuronal functioning. Choline and Acetate are taken up into the cytosol and recycled for the next activation.


This pathway was inferred from Homo sapiens pathway WP528(r29049) with a 50% conversion rate.

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Ontology Terms



  1. Blusztajn JK, Wurtman RJ; ''Choline and cholinergic neurons.''; Science, 1983 PubMed Europe PMC Scholia


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106859view13:33, 17 September 2019MaintBotHMDB identifier normalization
90725view22:25, 13 December 2016KhanspersReverted to version '18:27, 6 October 2016' by Khanspers
90724view22:24, 13 December 2016KhanspersModified description
89966view18:27, 6 October 2016Mkutmonfixed unconnected lines
78431view10:26, 7 January 2015MaintBotadded missing graphIds
75235view21:32, 12 May 2014Khanspersfixed lines
69151view18:17, 8 July 2013MaintBotUpdated to 2013 gpml schema
67025view09:55, 26 June 2013Christine ChichesterOntology Term : 'acetylcholine metabolic pathway' added !
42542view20:15, 1 April 2011ToxlabCorrected external references for matabolites
41338view00:25, 2 March 2011MaintBotRemoved redundant pathway information and comments
35060view10:57, 11 February 2010Thomasadded literature, fixed acetate annotation
34405view23:04, 9 December 2009MaintBotAutomatic update of empty xrefs
32835view19:12, 14 September 2009MaintBotAdded xrefs
31986view13:12, 14 August 2009MaintBotFixed group labels
30869view00:13, 30 July 2009MaintBotConverted from Homo sapiens
21047view11:30, 14 November 2008MaintBot[[Pathway:Mus musculus:Acetylcholine Synthesis]] moved to [[Pathway:WP175]]: Moved to stable identifier
7880view13:46, 7 January 2008MaintBot[[Pathway:Mouse:Acetylcholine Synthesis]] moved to [[Pathway:Mus musculus:Acetylcholine Synthesis]]: Renaming species
7565view16:00, 18 December 2007MaintBotfixed category names
7326view12:42, 4 November 2007MaintBotAdded categories to GPML
6410view22:18, 22 May 2007A.Kwagpml file for [[Mouse:Acetylcholine_Synthesis]]

External references


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NameTypeDatabase referenceComment
AcetateMetaboliteHMDB0000042 (HMDB)
Acetyl-CoAMetaboliteHMDB0001206 (HMDB)
AcetylcholineMetaboliteHMDB0000895 (HMDB)
AcheGeneProduct11423 (Entrez Gene)
ChatGeneProduct12647 (Entrez Gene)
ChkaGeneProduct12660 (Entrez Gene)
CholineMetaboliteHMDB0000097 (HMDB)
Cytidine diphosphate cholineMetaboliteHMDB0001413 (HMDB)
GlycerophosphocholineMetaboliteHMDB0000086 (HMDB)
Pcyt1aGeneProduct13026 (Entrez Gene)
Pdha1GeneProduct18597 (Entrez Gene)
Pdha2GeneProduct18598 (Entrez Gene)
PemtGeneProduct18618 (Entrez Gene)
PhosphatidylcholineMetaboliteHMDB0000564 (HMDB)
PhosphatidylethanolamineMetaboliteHMDB0011420 (HMDB)
PhosphorylcholineMetaboliteHMDB0001565 (HMDB)
Pyruvate from GlycolysisMetaboliteHMDB0000243 (HMDB)

Annotated Interactions

No annotated interactions
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