Eicosanoid Synthesis (Homo sapiens)

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1Cell MembraneLeukotriene A4ALOX15BALOX15PGD2Leukotriene B4Arachidonic acidLTA4HThromboxane B2ALOX5Prostaglandin F2aALOX5APPGE2 9-ketoreducPTGES2PTGS1Prostaglandin H2PGD2 11-ketoreducLeukotriene C4PTGESPer-oxidaseProstaglandin D2ALOX5APPLA2G2A5-HPETELeukotriene D4TBXAS1ALOX5GSH peroxidaseProstaglandin I2ALOX15PTGISLeukotriene E4Thromboxane A2LTC4SALOX12PNPLA3PTGDS5-HETEGGT1PLA2G6PNPLA8DPEP1PTGS212-HETE15-HETE12-HPETE15-HPETEProstaglandin E215-oxo-prostaglandin I2dehydrogenaseThromboxane A3Pla2g5GPPla2g6Pla2g4aPla2g4bPtgs1Ptgs2Ptgs1Ptgs2PGG2Arachidonic acid11-HETEALOX5PGJ215-deoxy-PGJ215-deoxy-PGD2


Description

In biochemistry, eicosanoids are signaling molecules made by oxidation of twenty-carbon essential fatty acids, (EFAs). They exert complex control over many bodily systems, mainly in inflammation or immunity, and as messengers in the central nervous system. Source: Wikipedia.

This pathway has been updated with information from Lipidmaps>Eicosanoids [1]. Metabolites and proteins from this pathway are orange coloured and have an rounded rectangle shape (where an oval shape indicates that the node only occures in the LipidMaps pathway). Reactions occurring in the lipidmaps pathways are coloured orange (where a dashed line indicates that the reaction only occures in the LipidMaps pathway).

Quality Tags

Ontology Terms

 

Bibliography

  1. Funk CD; ''Prostaglandins and leukotrienes: advances in eicosanoid biology.''; Science, 2001 PubMed
  2. Korff JM, Jarabak J; ''''; , PubMed

History

View all...
CompareRevisionActionTimeUserComment
102907view10:58, 28 January 2019DeSlModified description
102906view10:56, 28 January 2019DeSlChanged layout slightly, and annotated 2 missing metabolites.
98574view15:40, 17 September 2018DeSlModified description
98571view15:39, 17 September 2018DeSlChanged layout, coloured outside of node orange.
98564view13:36, 17 September 2018DeSlModified description
98563view13:32, 17 September 2018DeSlChanged layout, removed node colour.
98452view12:49, 7 September 2018DeSlRemoved "last modified" item
98451view12:49, 7 September 2018DeSlModified description
98450view12:48, 7 September 2018DeSlSLight layout change
98449view12:47, 7 September 2018DeSlOne more ID.
98448view12:45, 7 September 2018DeSlAnnotated more nodes.
98447view12:41, 7 September 2018DeSlAdded more IDs to new LipidMaps content
98431view15:39, 6 September 2018DeSlAdded remaining lipids from lipidmaps
98430view15:24, 6 September 2018DeSlModified description
98429view15:23, 6 September 2018DeSlReverted to version '15:22, 6 September 2018' by DeSl
98428view15:23, 6 September 2018DeSlModified description
98427view15:22, 6 September 2018DeSlModified description
98426view15:22, 6 September 2018DeSlModified description
98425view15:21, 6 September 2018DeSlModified description
98424view15:19, 6 September 2018DeSlModified description
98423view15:18, 6 September 2018DeSlModified description
98422view15:13, 6 September 2018DeSlModified description
98421view15:10, 6 September 2018DeSlAdded info from LipidMaps PW.
89514view10:45, 16 September 2016Mkutmonontology tag fix
89469view13:39, 15 September 2016Mkutmonremove space from ontology term id
82702view07:46, 23 October 2015EgonwReplaced to CAS numbers with the ChEBI identifiers: 70608-72-9 cannot be 5-HETE, 12-HETE, and 15-HETE at the same time.
79809view16:44, 16 April 2015Mkutmonfixed unconnected line
71381view18:40, 17 October 2013MaintBotAutomated update of data sources
67184view10:17, 26 June 2013Christine ChichesterOntology Term : 'eicosanoid biosynthetic pathway' added !
63178view20:30, 8 May 2013MaintBotUpdating gpml version
45234view17:44, 7 October 2011AlexanderPicoOntology Term : 'epithelial cell' added !
45226view17:36, 7 October 2011AlexanderPicoOntology Term : 'inflammatory response pathway' added !
45138view01:00, 7 October 2011AlexanderPicofixed reaction
45103view22:21, 6 October 2011AlexanderPicofixed reactions
45099view21:51, 6 October 2011AlexanderPicoupdated reactions
45098view21:46, 6 October 2011AlexanderPicoupdated refs and reactions
45095view21:16, 6 October 2011AlexanderPicodb refs
41942view18:41, 2 March 2011CarlospirolaPNPLA3 added
41939view17:39, 2 March 2011CarlospirolaPeriodical save, work in progress
41143view23:39, 1 March 2011MaintBotRemoved redundant pathway information and comments
35467view12:07, 12 February 2010Thomasadded literature
35466view12:06, 12 February 2010ThomasModified description
34433view18:14, 10 December 2009MaintBotAutomatic update of empty xrefs
31982view13:11, 14 August 2009MaintBotFixed group labels
21031view11:30, 14 November 2008MaintBot[[Pathway:Homo sapiens:Eicosanoid Synthesis]] moved to [[Pathway:WP167]]: Moved to stable identifier
15401view22:56, 27 May 2008Khanspersconnectors and metabolites
15399view22:53, 27 May 2008KhanspersPeriodical save, work in progress
15397view22:43, 27 May 2008KhanspersPeriodical save, work in progress
13058view11:12, 17 May 2008MaintBotautomated metabolite conversion
8002view13:46, 7 January 2008MaintBot[[Pathway:Human:Eicosanoid Synthesis]] moved to [[Pathway:Homo sapiens:Eicosanoid Synthesis]]: Renaming species

External references

DataNodes

View all...
NameTypeDatabase referenceComment
11-HETEMetaboliteQ27140010 (Wikidata)
12-HETEMetaboliteCHEBI:19138 (ChEBI)
12-HPETEMetabolite71030-35-8 (CAS)
15-HETEMetaboliteCHEBI:64017 (ChEBI)
15-HPETEMetabolite70981-96-3 (CAS)
15-deoxy-PGD2Metabolite5283052 (PubChem-compound)
15-deoxy-PGJ2Metabolite5311211 (PubChem-compound)
15-oxo-prostaglandin I2Metabolite
5-HETEMetabolite70608-72-9 (CAS)
5-HPETEMetaboliteHMDB01193 (HMDB)
ALOX12GeneProduct239 (Entrez Gene)
ALOX15GeneProduct246 (Entrez Gene)
ALOX15BGeneProduct247 (Entrez Gene)
ALOX5GeneProduct240 (Entrez Gene)
ALOX5APGeneProduct241 (Entrez Gene)
Arachidonic acidMetaboliteHMDB01043 (HMDB)
DPEP1GeneProduct1800 (Entrez Gene)
GGT1GeneProduct2678 (Entrez Gene)
GP
GSH peroxidaseGeneProduct1.11.1.9 (Enzyme Nomenclature)
LTA4HGeneProduct4048 (Entrez Gene)
LTC4SGeneProduct4056 (Entrez Gene)
Leukotriene A4MetaboliteHMDB01337 (HMDB)
Leukotriene B4MetaboliteHMDB01085 (HMDB)
Leukotriene C4MetaboliteHMDB01198 (HMDB)
Leukotriene D4MetaboliteHMDB03080 (HMDB)
Leukotriene E4MetaboliteHMDB02200 (HMDB)
PGD2 11-ketoreducGeneProduct1.1.1.188 (Enzyme Nomenclature)
PGD2MetaboliteQ419750 (Wikidata)
PGE2 9-ketoreducGeneProduct1.1.1.189 (Enzyme Nomenclature)
PGG2MetaboliteLMFA03010009 (LIPID MAPS)
PGJ2MetaboliteQ27088353 (Wikidata)
PLA2G2AGeneProduct5320 (Entrez Gene)
PLA2G6GeneProduct8398 (Entrez Gene)
PNPLA3GeneProductPNPLA3 (HGNC)
PNPLA8GeneProduct50640 (Entrez Gene)
PTGDSGeneProduct5730 (Entrez Gene)
PTGES2GeneProduct80142 (Entrez Gene)
PTGESGeneProduct9536 (Entrez Gene)
PTGISGeneProduct5740 (Entrez Gene)
PTGS1GeneProduct5742 (Entrez Gene)
PTGS2GeneProduct5743 (Entrez Gene)
Per- oxidaseGeneProduct1.11.1.7 (Enzyme Nomenclature)
Pla2g4aProtein5321 (Entrez Gene)
Pla2g4bProtein100137049 (Entrez Gene)
Pla2g5Protein5322 (Entrez Gene)
Pla2g6Protein8398 (Entrez Gene)
Prostaglandin D2MetaboliteHMDB01403 (HMDB)
Prostaglandin E2Metabolite363-24-6 (CAS)
Prostaglandin F2aMetaboliteHMDB01139 (HMDB)
Prostaglandin H2MetaboliteHMDB01381 (HMDB)
Prostaglandin I2MetaboliteHMDB01335 (HMDB)
Ptgs1Protein5742 (Entrez Gene)
Ptgs2Protein5743 (Entrez Gene)
TBXAS1GeneProduct6916 (Entrez Gene)
Thromboxane A2MetaboliteHMDB01452 (HMDB)
Thromboxane A3Metabolite5283139 (PubChem-compound)
Thromboxane B2MetaboliteHMDB03252 (HMDB)
dehydrogenaseGeneProduct1.1.1.231 (Enzyme Nomenclature)

Annotated Interactions

No annotated interactions

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