Apoptosis Modulation by HSP70 (Mus musculus)

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InhibitionDegradation ofIk alpha(activation of NFkB)TNF-alphaInhibitionActivationInhibitionInhibitionDegradation of proteinsMitochondriaProteasomeNF-kBpathwayAPOPTOSISSTRESSFAS-LigandCELL SURVIVALApoptosomeFaddGm10108Tnfrsf1aCasp2Mapk10Hspa1aBidCasp8Ripk1FasApaf1Casp6Casp3FaddHspa1aMap3k1Casp7Nfkb1Gm10108Hspa1aCasp8Aifm1Casp9


This pathway summarizes the various ways by which HSP70 proteins can inhibit apoptosis. This pathway was originally adapted from rat.


GenMAPP notes 
References of HSP70 and inhibition of apoptosis:

1. Garrido C, Schmitt E, Cande C, Vahsen N, Parcellier A, Kroemer G. HSP27 and HSP70: potentially oncogenic apoptosis inhibitors. Cell Cycle. 2003 Nov-Dec;2(6):579-84. PMID: 14512773 [PubMed - in process]
2. Mosser DD, Caron AW, Bourget L, Meriin AB, Sherman MY, Morimoto RI, Massie B. The chaperone function of hsp70 is required for protection against stress-induced apoptosis. Mol Cell Biol. 2000 Oct;20(19):7146-59. PMID: 10982831 [PubMed - indexed for MEDLINE]
3. Saleh A, Srinivasula SM, Balkir L, Robbins PD, Alnemri ES. Negative regulation of the Apaf-1 apoptosome by Hsp70. Nat Cell Biol. 2000 Aug;2(8):476-83. PMID: 10934467 [PubMed - indexed for MEDLINE]
4. Schett G, Steiner CW, Groger M, Winkler S, Graninger W, Smolen J, Xu Q, Steiner G. Activation of Fas inhibits heat-induced activation of HSF1 and up-regulation of hsp70. FASEB J. 1999 May;13(8):833-42. PMID: 10224227 [PubMed - indexed for MEDLINE]
5. Gabai VL, Meriin AB, Yaglom JA, Volloch VZ, Sherman MY. Role of Hsp70 in regulation of stress-kinase JNK: implications in apoptosis and aging. FEBS Lett. 1998 Oct 30;438(1-2):1-4. Review. PMID: 9821948 [PubMed - indexed for MEDLINE]
6. Jaattela M, Wissing D, Kokholm K, Kallunki T, Egeblad M. Hsp70 exerts its anti-apoptotic function downstream of caspase-3-like proteases.
EMBO J. 1998 Nov 2;17(21):6124-34. PMID: 9799222 [PubMed - indexed for MEDLINE]
7. Orsini F, Migliaccio E, Moroni M, Contursi C, Raker VA, Piccini D, Martin-Padura I, Pelliccia G, Trinei M, Bono M, Puri C, Tacchetti C, Ferrini M, Mannucci R, Nicoletti I, Lanfrancone L, Giorgio M, Pelicci P. The life span determinant p66Shc localizes to mitochondria where it associates with mtHsp70 and regulates trans-membrane potential. J Biol Chem. 2004 Apr 12 [Epub ahead of print] 
PMID: 15078873 [PubMed - as supplied by publisher]
8. Gurbuxani S, Schmitt E, Cande C, Parcellier A, Hammann A, Daugas E, Kouranti I, Spahr C, Pance A, Kroemer G, Garrido C. Heat shock protein 70 binding inhibits the nuclear import of apoptosis-inducing factor. Oncogene. 2003 Oct 2;22(43):6669-78. 
PMID: 14555980 [PubMed - indexed for MEDLINE]

GenMAPP remarks 
Right click for info. Adapted from rat by GenMAPP
This pathway was inferred from Homo sapiens pathway WP384(r29910) with a 86% conversion rate.

Quality Tags

Ontology Terms



No bibliography


View all...
98541view20:50, 14 September 2018KhanspersModified description
72008view12:21, 24 October 2013Mkutmonfixed unconnected lines
69185view18:22, 8 July 2013MaintBotUpdated to 2013 gpml schema
67053view10:00, 26 June 2013Christine ChichesterOntology Term : 'apoptotic cell death pathway' added !
41376view00:28, 2 March 2011MaintBotRemoved redundant pathway information and comments
32716view23:27, 2 September 2009MaintBotAdded xrefs
32354view13:39, 15 August 2009MaintBotFixed text labels
31981view13:11, 14 August 2009MaintBotFixed group labels
31403view20:50, 13 August 2009MaintBotFixed text labels
30913view00:28, 30 July 2009MaintBotConverted from Homo sapiens
21029view11:30, 14 November 2008MaintBot[[Pathway:Mus musculus:HSP70 and Apoptosis]] moved to [[Pathway:WP166]]: Moved to stable identifier
8142view13:46, 7 January 2008MaintBot[[Pathway:Mouse:HSP70 and Apoptosis]] moved to [[Pathway:Mus musculus:HSP70 and Apoptosis]]: Renaming species
7691view16:10, 18 December 2007MaintBotfixed category names
7233view12:41, 4 November 2007MaintBotAdded categories to GPML
6454view22:19, 22 May 2007I.Reyesgpml file for [[Mouse:HSP70_and_Apoptosis]]

External references


View all...
NameTypeDatabase referenceComment
Aifm1GeneProduct26926 (Entrez Gene) Apoptosis Inducing Factor
Apaf1GeneProduct11783 (Entrez Gene)
BidGeneProduct12122 (Entrez Gene)
Casp2GeneProduct12366 (Entrez Gene)
Casp3GeneProduct12367 (Entrez Gene)
Casp6GeneProduct12368 (Entrez Gene)
Casp7GeneProduct12369 (Entrez Gene)
Casp8GeneProduct12370 (Entrez Gene)
Casp9GeneProduct12371 (Entrez Gene)
FaddGeneProduct14082 (Entrez Gene)
FasGeneProduct14102 (Entrez Gene)
Gm10108GeneProduct670717 (Entrez Gene)
Hspa1aGeneProduct193740 (Entrez Gene)
Map3k1GeneProduct26401 (Entrez Gene)
Mapk10GeneProduct26414 (Entrez Gene)
Nfkb1GeneProduct18033 (Entrez Gene)
Ripk1GeneProduct19766 (Entrez Gene)
Tnfrsf1aGeneProduct21937 (Entrez Gene)

Annotated Interactions

No annotated interactions
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