Ascorbate and aldarate metabolism (Mycobacterium tuberculosis)

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1-3Amino sugar and nucleotide sugar metabolismL-Ascorbatealdehyde dehydrogenase (EC:1.2.1.-)aldAL-xylo-HexulonolactoneL-Gulono-1,4-lactoneD-GlucaratealdCL-gulonolactone oxidaseudgAUDP-glucosealdehyde dehydrogenase (EC:


Source: KEGG Pathways.

The Ascorbate and aldarate metabolism for Mycobacterium tuberculosis is not completely understood yet; conversions which are not clear are depicted with a dashed arrow.

Two out of the three literature references provided for this pathway are for E. coli and could be not specific enough for Mycobacterium tuberculosis.

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Ontology Terms



  1. Zhang Z, Aboulwafa M, Smith MH, Saier MH Jr; ''The ascorbate transporter of Escherichia coli.''; J Bacteriol, 2003 PubMed Europe PMC Scholia
  2. Campos E, Baldoma L, Aguilar J, Badia J; ''Regulation of expression of the divergent ulaG and ulaABCDEF operons involved in LaAscorbate dissimilation in Escherichia coli.''; J Bacteriol, 2004 PubMed Europe PMC Scholia
  3. Rahman SA, Singh Y, Kohli S, Ahmad J, Ehtesham NZ, Tyagi AK, Hasnain SE; ''Comparative analyses of nonpathogenic, opportunistic, and totally pathogenic mycobacteria reveal genomic and biochemical variabilities and highlight the survival attributes of Mycobacterium tuberculosis.''; MBio, 2014 PubMed Europe PMC Scholia


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95452view13:26, 15 December 2017DeSlModified description
95451view13:26, 15 December 2017DeSlAdded another literature reference
95450view13:23, 15 December 2017DeSlOntology Term : 'glucose conversion pathway' added !
95449view13:22, 15 December 2017DeSlModified description
95448view13:20, 15 December 2017DeSlRemoved licence number
95447view13:05, 15 December 2017DeSlAdded literature references, changed arrows to MIM type conversion.
95446view13:00, 15 December 2017DeSlRemoved all not existing IDs and conversions, added correct IDs (iso KEGG orthologs); connected all lines+proteins.
89512view10:45, 16 September 2016Mkutmonontology tag fix
89479view13:39, 15 September 2016Mkutmonremove space from ontology term id
72235view08:48, 29 October 2013EgonwReplaced Kegg enzyme with Enzyme Nomenclature as database for EC numbers.
71648view19:34, 17 October 2013MaintBotAutomated update of data sources
71164view07:20, 11 October 2013Mkutmonconnected lines
69569view20:19, 8 July 2013MaintBotUpdated to 2013 gpml schema
67064view10:01, 26 June 2013Christine ChichesterOntology Term : 'ascorbate and aldarate metabolic pathway' added !
41505view01:11, 2 March 2011MaintBotRemoved redundant pathway information and comments
38999view19:45, 25 September 2010AlexanderPicoModified description
38998view19:45, 25 September 2010AlexanderPico
38997view19:44, 25 September 2010AlexanderPicoModified categories
38620view10:48, 22 September 2010AllanKuchinskystraightened some lines
38509view17:37, 21 September 2010MaintBotNew pathway

External references


View all...
NameTypeDatabase referenceComment
D-GlucarateMetaboliteC00818 (KEGG Compound)
D-GlucuronolactoneMetaboliteC02670 (KEGG Compound)
L-AscorbateMetaboliteC00072 (KEGG Compound)
L-Gulono-1,4-lactoneMetaboliteC01040 (KEGG Compound)
L-gulonolactone oxidaseProtein1.1.3.8 (Enzyme Nomenclature)
L-xylo-HexulonolactoneMetaboliteC03289 (KEGG Compound)
UDP-glucoseMetaboliteC00029 (KEGG Compound)
UDP-glucuronateMetaboliteC00167 (KEGG Compound)
aldAProteinNP_215282 (NCBI Protein) Original kegg element: gene;67;mtu:Rv0147 mtu:Rv0458 mtu:Rv0768 mtu:Rv2858c
aldCProteinNP_217374 (NCBI Protein) Original kegg element: gene;67;mtu:Rv0147 mtu:Rv0458 mtu:Rv0768 mtu:Rv2858c
aldehyde dehydrogenase (EC:1.2.1.-)ProteinNP_214737 (NCBI Protein) Original kegg element: gene;67;mtu:Rv0147 mtu:Rv0458 mtu:Rv0768 mtu:Rv2858c
aldehyde dehydrogenase (EC: (NCBI Protein) Original kegg element: gene;67;mtu:Rv0147 mtu:Rv0458 mtu:Rv0768 mtu:Rv2858c
udgAProtein1.1.1.22 (Enzyme Nomenclature) Original kegg element: gene;15;mtu:Rv0322

Annotated Interactions

No annotated interactions

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