Selenium Micronutrient Network (Homo sapiens)

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2119110, 195, 235, 2631879, 16, 26, 32, 70...41, 2241021127, 109, 211, 24025159, 20061, 64, 25666, 83117, 15021210713311718, 29, 65, 240130StimulationInhibitionSelenium statusStatusConversionCleavageBiomarker forInflammation and immune responseLipoprotein melabolismMicronutrientsBindingOxidative stressSelenoproteinsCatalysisLeukotriene metabolismMetabolic stressCofactor conversionMetabolitesProcess or metabolism involved in Se PathwayOverarching processReactionCofactorsOther proteinsLipid peroxidationLEGENDTranscription factoris composed ofNecessary stimulationFrom intracellular part to the plasmaTryptophan metabolismProtein tyrosine nitrationGlycogenesisEnzymesProstaglandins metabolismCa++ metabolismNegative EffectIntracellularER protein foldingGlutathione metabolismNAD+ metabolismFolate metabolismDNA oxidationPlasmaPGI2DPAPGF2aPGF2aNFkB28-Isoprostaglandin F2aRELAF2-IsoprostaneNFkB1Arachidonic acidPGI2PGE1PGH2MDAMDALinoleic acidEPAPGD2PGE3COX1PGG2a-TocopherolALAPGE2PGH3Thromboxane B2Linoleic acidThromboxane B2Arachidonic acidThromboxane A2DHAEPALipoxin B4Lipoxin A4ALALipoxin B4PGD2PGE2DHA8-Isoprostaglandin F2aLipoxin A4DGLAF2-IsoprostaneCOX2PGE1DPAa-Tocopherol3517235, 24416, 80, 114, 141, 146...2193546, 14192, 146, 197, 199, 2362068092, 102, 146, 197, 199...73182, 191, 196, 20618215, 73, 15273802062192068015935, 24446, 14187, 11587, 1157346, 14138, 73801591911524, 2067324473, 23721980, 87, 115, 172, 18224473, 14521973152Kynurenine150MTR91, 106TRXR1CBS36, 106IodineIodine113113KMO1505-HETEThyroxine (T4)R-Triiodothyronine (rT3)Triiodothyronine (T3)5-HETE5-HPETE15-HETETriiodothyronine (T3)5,6-EpoxytetraeneThyroxine (T4)15-HETER-Triiodothyronine (rT3)32, 162, 172105, 113219105, 113105, 17017232, 162, 172105, 170105, 113172, 21932, 162, 172105, 170NADP+MPOCatalaseMPO2727, 67, 88, 22340, 211Uric acid41, 180CysteinePLGGGT1ThrombinFactor VIIPAI-1PLGFactor VIIThrombintPAPAI-1tPA7474148, 15518874148, 1557474148, 22774148, 227GPX 4TRXR2Xantine oxidase49, 180PRDX5H2O2ALOX5ALOX15B114, 151, 194, 199, 219158, 172CopperUric acid41, 180Vitamin B1289, 1165,10-Methylene-THFSelR109, 121Tryptophan117, 1505-methyl-THFSOD3PRDX1RFK93H2OGPX 3NiacinamideCTH106PNPO135Heme15, 36, 40, 211, 212NADPHLipoic acid235ManganeseFAD78Methionine sulfoxide109Dehydroascorbic acid17, 195Leukotriene A4144, 186NADPHFAD78THFHydroxykynurenine150Folic acid91NADP+NADPHSeleniumSelenium118118SelKSep1518, 225, 240147GPX 6GSH198Nicotinamidase117Calcium186Methionine109ManganeseNADPHFolic acid91FMN78SelenideSelenocysteineSelenophosphate105, 263105, 263105, 263CysteineLeukotriene C4Leukotriene C4186, 188GPX 326Dehydroascorbic acid195GPX 2SelP209Trx-S210, 195, 235Ascorbic acid17Lipoic acid235PRDX4GPX 1NADP+HomocysteineROSRNS107, 21117, 29, 49, 55, 56, 64...NADPHVitamin B1289, 116MTHFR91Homocysteine227SelISelOSelNDIO2SPS2SelVSelPSelHSelMSelSSelTDIO1DIO3105, 113105, 11320390, 111, 201, 209133, 22161, 203, 256105, 22055, 65, 12020364, 203105, 113, 26629, 216, 226203SOD1Pyridoxal 5'-phosphate150SerineIron186HypoxanthinePRDX3GSR103SAA4SAA2VLDLSAA3SRB1VLDLLDLVLDL-TAGHDL/SAAABCA1FMNAPOBTAGAPOA1-NO2TyrACTACTHDL/APOA1HDLoxLDLHDL-CLDLCholesterolVLDL-TAGAPOA1HDL-CHDLSAA1APOBAPOA1CholesterolLDLRVLDL/APOBoxLDLTAG101, 2539, 66, 200, 223101839, 66, 200, 22310183, 18183, 181, 22283, 1819, 66, 102, 200, 223838310183101, 253101488322283, 22210110183838310183, 1817848, 85, 2349, 66, 102, 200, 223883, 18148, 85, 23483O2159Pyridoxal 5'-phosphate1508-OHdGFAD8-OHdG78130130PRDX2ADPLeukotriene D4Leukotriene D4188CopperChlorineChlorineCystathionineFAD78SOD2Dihydrolipoate204, 235SerineNADP+ATPZincNADP+GSSGNADPHZincNiacinLeukotriene B4Leukotriene B4144, 186144Quinolinic Acid117, 150PMPNO2NOHNO2NOO3HOCl67, 8867, 88NADP+GSH133, 144, 198HBA1D-dimerINSIFNgHBBsICAM-1FibrinHbA1cIL10ALBFLAPIFNgCCL2sICAM-1D-dimerFibrinogenCRPIL10CCL2HbA1cTNFaINSIL1BFibrinINSRTNFaFibrinogenIL6ALBIL6IL1B58, 7426642, 68, 14210442, 68, 14215174, 1552665, 33, 26690, 120, 1495, 42, 102, 20012425, 72, 129, 20856, 20112012056, 20125, 72, 129, 208, 25372, 20874, 15556, 68, 120, 14910458, 7468, 90, 2663320120112433104104SelW137, 198, 257Riboflavin143SOD3224TRXR110Ascorbate17, 195O2-“XanthineCalcium186Kynureninase150Methionine109ADPTrx-(SH)210, 235NitrotyrosineNitrotyrosineONOO-/ONOOH107107ATPLeukotriene E4Leukotriene E4188FructosamineLeukotriene F4FructosamineGlucose12425, 104124168, 188Iron186HypoxanthineTRXR3FLAD193, 110Ascorbic acid17, 92, 236