Selenium Micronutrient Network (Homo sapiens)
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211
91
10, 195, 235, 263
187
9, 16, 26, 32, 70...
41, 224
10
211
27, 109, 211, 240
25
159, 200
61, 64, 256
66, 83
117, 150
212
107
133
117
18, 29, 65, 240
130
Stimulation
Inhibition
Selenium status
Status
Conversion
Cleavage
Biomarker for
Inflammation and
immune response
Lipoprotein melabolism
Micronutrients
Binding
Oxidative stress
Selenoproteins
Catalysis
Leukotriene metabolism
Metabolic stress
Cofactor conversion
Metabolites
Process or metabolism involved in Se Pathway
Overarching process
Reaction
Cofactors
Other proteins
Lipid peroxidation
LEGEND
Transcription factor
is composed of
Necessary stimulation
From intracellular part to the plasma
Tryptophan metabolism
Protein tyrosine nitration
Glycogenesis
Enzymes
Prostaglandins metabolism
Ca++ metabolism
Negative Effect
Intracellular
ER protein folding
Glutathione metabolism
NAD+ metabolism
Folate metabolism
DNA oxidation
Plasma
PGI2
DPA
PGF2a
PGF2a
NFkB2
8-Isoprostaglandin F2a
RELA
F2-Isoprostane
NFkB1
Arachidonic acid
PGI2
PGE1
PGH2
MDA
MDA
Linoleic acid
EPA
PGD2
PGE3
COX1
PGG2
a-Tocopherol
ALA
PGE2
PGH3
Thromboxane B2
Linoleic acid
Thromboxane B2
Arachidonic acid
Thromboxane A2
DHA
EPA
Lipoxin B4
Lipoxin A4
ALA
Lipoxin B4
PGD2
PGE2
DHA
8-Isoprostaglandin F2a
Lipoxin A4
DGLA
F2-Isoprostane
COX2
PGE1
DPA
a-Tocopherol
35
172
35, 244
16, 80, 114, 141, 146...
219
35
46, 141
92, 146, 197, 199, 236
206
80
92, 102, 146, 197, 199...
73
182, 191, 196, 206
182
15, 73, 152
73
80
206
219
206
80
159
35, 244
46, 141
87, 115
87, 115
73
46, 141
38, 73
80
159
191
152
4, 206
73
244
73, 237
219
80, 87, 115, 172, 182
244
73, 145
219
73
152
Kynurenine
150
MTR
91, 106
TRXR1
CBS
36, 106
Iodine
Iodine
113
113
KMO
150
5-HETE
Thyroxine (T4)
R-Triiodothyronine (rT3)
Triiodothyronine (T3)
5-HETE
5-HPETE
15-HETE
Triiodothyronine (T3)
5,6-Epoxytetraene
Thyroxine (T4)
15-HETE
R-Triiodothyronine (rT3)
32, 162, 172
105, 113
219
105, 113
105, 170
172
32, 162, 172
105, 170
105, 113
172, 219
32, 162, 172
105, 170
NADP+
MPO
Catalase
MPO
27
27, 67, 88, 223
40, 211
Uric acid
41, 180
Cysteine
PLG
GGT1
Thrombin
Factor VII
PAI-1
PLG
Factor VII
Thrombin
tPA
PAI-1
tPA
74
74
148, 155
188
74
148, 155
74
74
148, 227
74
148, 227
GPX 4
TRXR2
Xantine oxidase
49, 180
PRDX5
H2O2
ALOX5
ALOX15B
114, 151, 194, 199, 219
158, 172
Copper
Uric acid
41, 180
Vitamin B12
89, 116
5,10-Methylene-THF
SelR
109, 121
Tryptophan
117, 150
5-methyl-THF
SOD3
PRDX1
RFK
93
H2O
GPX 3
Niacinamide
CTH
106
PNPO
135
Heme
15, 36, 40, 211, 212
NADPH
Lipoic acid
235
Manganese
FAD
78
Methionine sulfoxide
109
Dehydroascorbic acid
17, 195
Leukotriene A4
144, 186
NADPH
FAD
78
THF
Hydroxykynurenine
150
Folic acid
91
NADP+
NADPH
Selenium
Selenium
118
118
SelK
Sep15
18, 225, 240
147
GPX 6
GSH
198
Nicotinamidase
117
Calcium
186
Methionine
109
Manganese
NADPH
Folic acid
91
FMN
78
Selenide
Selenocysteine
Selenophosphate
105, 263
105, 263
105, 263
Cysteine
Leukotriene C4
Leukotriene C4
186, 188
GPX 3
26
Dehydroascorbic acid
195
GPX 2
SelP
209
Trx-S2
10, 195, 235
Ascorbic acid
17
Lipoic acid
235
PRDX4
GPX 1
NADP+
Homocysteine
ROS
RNS
107, 211
17, 29, 49, 55, 56, 64...
NADPH
Vitamin B12
89, 116
MTHFR
91
Homocysteine
227
SelI
SelO
SelN
DIO2
SPS2
SelV
SelP
SelH
SelM
SelS
SelT
DIO1
DIO3
105, 113
105, 113
203
90, 111, 201, 209
133, 221
61, 203, 256
105, 220
55, 65, 120
203
64, 203
105, 113, 266
29, 216, 226
203
SOD1
Pyridoxal 5'-phosphate
150
Serine
Iron
186
Hypoxanthine
PRDX3
GSR
103
SAA4
SAA2
VLDL
SAA3
SRB1
VLDL
LDL
VLDL-TAG
HDL/SAA
ABCA1
FMN
APOB
TAG
APOA1-NO2Tyr
ACT
ACT
HDL/APOA1
HDL
oxLDL
HDL-C
LDL
Cholesterol
VLDL-TAG
APOA1
HDL-C
HDL
SAA1
APOB
APOA1
Cholesterol
LDLR
VLDL/APOB
oxLDL
TAG
101, 253
9, 66, 200, 223
101
83
9, 66, 200, 223
101
83, 181
83, 181, 222
83, 181
9, 66, 102, 200, 223
83
83
101
83
101, 253
101
48
83
222
83, 222
101
101
83
83
83
101
83, 181
78
48, 85, 234
9, 66, 102, 200, 223
8
83, 181
48, 85, 234
83
O2
159
Pyridoxal 5'-phosphate
150
8-OHdG
FAD
8-OHdG
78
130
130
PRDX2
ADP
Leukotriene D4
Leukotriene D4
188
Copper
Chlorine
Chlorine
Cystathionine
FAD
78
SOD2
Dihydrolipoate
204, 235
Serine
NADP+
ATP
Zinc
NADP+
GSSG
NADPH
Zinc
Niacin
Leukotriene B4
Leukotriene B4
144, 186
144
Quinolinic Acid
117, 150
PMP
NO2
NO
HNO2
NO
O3
HOCl
67, 88
67, 88
NADP+
GSH
133, 144, 198
HBA1
D-dimer
INS
IFNg
HBB
sICAM-1
Fibrin
HbA1c
IL10
ALB
FLAP
IFNg
CCL2
sICAM-1
D-dimer
Fibrinogen
CRP
IL10
CCL2
HbA1c
TNFa
INS
IL1B
Fibrin
INSR
TNFa
Fibrinogen
IL6
ALB
IL6
IL1B
58, 74
266
42, 68, 142
104
42, 68, 142
151
74, 155
266
5, 33, 266
90, 120, 149
5, 42, 102, 200
124
25, 72, 129, 208
56, 201
120
120
56, 201
25, 72, 129, 208, 253
72, 208
74, 155
56, 68, 120, 149
104
58, 74
68, 90, 266
33
201
201
124
33
104
104
SelW
137, 198, 257
Riboflavin
143
SOD3
224
TRXR1
10
Ascorbate
17, 195
O2-“
Xanthine
Calcium
186
Kynureninase
150
Methionine
109
ADP
Trx-(SH)2
10, 235
Nitrotyrosine
Nitrotyrosine
ONOO-/ONOOH
107
107
ATP
Leukotriene E4
Leukotriene E4
188
Fructosamine
Leukotriene F4
Fructosamine
Glucose
124
25, 104
124
168, 188
Iron
186
Hypoxanthine
TRXR3
FLAD1
93, 110
Ascorbic acid
17, 92, 236