Selenium micronutrient network (Homo sapiens)

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28160, 227, 237, 26174, 14021022713421210, 44, 52, 58, 73...2828, 99, 128, 17861, 143, 19182, 17462155, 19892, 189351073015538, 42, 72, 17816Transcription factorLipid peroxidationis composed ofCofactorsCa++ metabolismSelenium statusCleavageNegative EffectEnzymesBiomarker forProstaglandins metabolismLipoprotein melabolismOxidative stressCofactor conversionInflammation and immune responseInhibitionMetabolic stressOther proteinsLeukotriene metabolismProcess or metabolism involved in Se PathwayMetabolitesProtein tyrosine nitrationStimulationNecessary stimulationBindingOverarching processFrom intracellular part to the plasmaReactionStatusConversionGlycogenesisLEGENDMicronutrientsCatalysisSelenoproteinsTryptophan metabolismIntracellularGlutathione metabolismNAD+ metabolismER protein foldingDNA oxidationFolate metabolismPlasmaPGF2aPGH3F2-Isoprostane8-Isoprostaglandin F2aLipoxin A4PGH2Thromboxane B2PGE2MDALinoleic acidThromboxane B2PGD2PGE2RELAMDAPGD2DGLAEPALinoleic acid8-Isoprostaglandin F2aPGE1PGI2Lipoxin B4NFkB2PGG2NFkB1Arachidonic acidALAFGAa-TocopherolDPALipoxin B4DHACOX1PGI2Arachidonic acidEPAPGE1COX2F2-IsoprostaneLipoxin A4PGE3ALAThromboxane A2PGF2aDHAa-TocopherolDPA2055, 176, 21355, 228197, 229, 245, 252, 268174272291972355127555, 26520, 20722922976, 114, 129, 151, 182...555555, 20522917423, 27, 87, 19727, 63245, 25220, 2071275, 2652681275, 23, 27, 73, 87...27202135, 26521327245, 25220776, 129, 151, 182, 1921275555, 146207Kynurenine198MTR134, 217TRXR1CBS93, 217IodineIodine22KMO198Triiodothyronine (T3)15-HETER-Triiodothyronine (rT3)5-HETEThyroxine (T4)R-Triiodothyronine (rT3)5,6-EpoxytetraeneThyroxine (T4)5-HETE5-HPETETriiodothyronine (T3)15-HETE10, 54, 268127, 26846, 13112746, 1312, 4646, 13110, 54, 2682, 462, 4626810, 54, 268NADP+CatalaseMPOMPO28, 519914, 99, 115, 238Uric acid74, 142CysteineGGT1Factor VIIFactor VIIPAI-1PAI-1PLGtPAtPAThrombinThrombinPLG267267113, 19332, 113267267113, 19326716226732, 113GPX 4TRXR2Xantine oxidase80, 142PRDX5H2O2ALOX5ALOX15B44, 73, 127, 182, 20952, 268CopperUric acid74, 142Vitamin B1264, 2045,10-Methylene-THFSelR125, 128Tryptophan155, 1985-methyl-THFSOD3PRDX1RFK53H2OGPX 3NiacinamideCTH217PNPO117Heme28, 51, 62, 93, 176NADPHLipoic acid237ManganeseFAD116Methionine sulfoxide128Dehydroascorbic acid235, 261Leukotriene A4168, 180NADPHFAD116THFHydroxykynurenine198Folic acid134NADP+NADPHSeleniumSelenium187187Sep15SelK16672, 104, 178GPX 6GSH17Nicotinamidase155Calcium180Methionine128ManganeseNADPHFolic acid134FMN116SelenophosphateSelenideSelenocysteine46, 16046, 16046, 160CysteineLeukotriene C4Leukotriene C4162, 180GPX 358Dehydroascorbic acid261GPX 2SelP141Trx-S2227, 237, 261Ascorbic acid235Lipoic acid237PRDX4GPX 1NADP+HomocysteineRNSROS28, 30, 42, 57, 61...28, 35NADPHVitamin B1264, 204MTHFR134Homocysteine32SelISelVDIO2SelPSPS2DIO3DIO1SelOSelSSelNSelTSelMSelH19, 143, 19146, 12330, 7919103, 121, 141, 1691942, 88, 1122, 462, 46, 15038, 219, 2221919, 612, 46SOD1Pyridoxal 5'-phosphate198SerineIron180HypoxanthinePRDX3GSR68LDLAPOA1-NO2TyrACTTAGoxLDLLDLCholesterolHDL-CVLDLTAGAPOBoxLDLSAA1APOA1CholesterolVLDL-TAGABCA1ACTAPOBVLDLHDLSAA3APOA1FMNLDLRSAA4HDL/APOA1VLDL/APOBHDLSRB1SAA2HDL/SAAVLDL-TAGHDL-C979270, 185, 21882, 115, 163, 189929714782, 114, 115, 163, 18992921169270, 185, 21856, 979297979756, 9792, 17921470979292, 14792, 17992, 147, 17992, 17982, 115, 163, 1899292, 17982, 114, 115, 163, 1899297O2174Pyridoxal 5'-phosphate1988-OHdGFAD8-OHdG1161616PRDX2ADPLeukotriene D4Leukotriene D4162ChlorineChlorineCopperCystathionineFAD116SOD2Dihydrolipoate201, 237SerineNADP+ATPZincNADP+GSSGNADPHZincNiacinLeukotriene B4Leukotriene B4168168, 180Quinolinic Acid155, 198PMPO3NO2HNO2HOClNONO14, 23814, 238NADP+GSH17, 30, 168IFNgD-dimerIFNgCCL2HbA1cFibrinsICAM-1FLAPIL1BINSIL10INSRHBBALBIL6FibrinogenHbA1cTNFaINSCRPCCL2IL10D-dimerFibrinogenHBA1sICAM-1TNFaALBFibrinIL1BIL657, 12121021956, 106, 107, 144, 1961219, 82, 114, 23157, 121106, 107, 144, 1965913512137, 267138, 159, 2311509, 150, 210132, 169, 219150, 159, 169106, 196135193, 2675915037, 26720957, 132, 159, 21959219193, 267138, 159, 23159SelW17, 152, 177Riboflavin249SOD3140TRXR1227Ascorbate235, 261O2-“XanthineCalcium180Kynureninase198Methionine128ADPTrx-(SH)2227, 237ONOO-/ONOOHNitrotyrosineNitrotyrosine3535ATPLeukotriene E4Leukotriene E4162Leukotriene F4GlucoseFructosamineFructosamine6, 16213513559, 107Iron180HypoxanthineTRXR3FLAD153, 67Ascorbic acid76, 151, 235FGBFGG