MicroRNAs in Cardiomyocyte Hypertrophy (Mus musculus)

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14141314141421413114131131581RCAN1 promotorGPCRCelmembraneGβγCellular ProteinsTranscription FactorsGαq/α11GC-ANucleusTGFR/ActivinStretchStressRASProtein SynthesisTNFRHypertrophic gene transcriptionRTKsCatecholaminesGPCRRhoStressPI3KSarcomere organizationPol IImmu-mir-130bCalciumCalciumFzd2mmu-mir-15bmmu-mir-199a-2Nfatc4mmu-mir-199a-2mmu-mir-15bmmu-mir-27bmmu-mir-195Egfmmu-let-7bmmu-mir-214mmu-mir-27bmmu-mir-103-1Tgfb1mmu-mir-199a-2Akt2mmu-mir-125b-2mmu-mir-185Nfatc4mmu-mir-133a-1Stat3LifCishLrp5Rhoammu-mir-30emmu-mir-23ammu-let-7bmmu-mir-23aMap2k4mmu-mir-27bmmu-mir-125b-1mmu-mir-133bmmu-mir-199a-2mmu-mir-103-2Plcb2mmu-mir-15bPik3r2Igf1rmmu-mir-133a-1mmu-mir-30emmu-mir-133bmmu-mir-133a-2Pdpk1Nfkb1Camk2dPrkcbMap2k6mmu-mir-15bmmu-mir-133bStat3Myef2mmu-mir-30emmu-mir-199a-1mmu-mir-140NppaCdk9mmu-mir-199a-1Map2k1CaMMapk4Mapk8mmu-mir-30emmu-mir-15bCalciummmu-mir-195mmu-mir-27bGsk3bMap2k5mmu-let-7bmmu-mir-21Lrp6Map2k2mmu-mir-130bMap3k7ip1mmu-mir-208ammu-mir-103-1Pik3cgCdk7mmu-mir-15bmmu-mir-23ammu-mir-125b-2Dvl1Hdac4mmu-mir-15bMylkRaf1Igf1mmu-mir-125b-1mmu-mir-125b-2Agtmmu-mir-23aMapk3Rock2Mtormmu-mir-140mmu-mir-30emmu-mir-208aFzd1Ikbkemmu-mir-30eEdn1mmu-mir-195Hdac7mmu-mir-195mmu-let-7bmmu-mir-30emmu-mir-199a-1Il6stPik3cammu-mir-195Pik3cdmmu-mir-27bmmu-mir-208aMapk1Prkcbmmu-mir-125b-2mmu-mir-30eRcan1mmu-mir-195Nfatc4Rock1mmu-mir-199a-2Mapk3Ppp3cbmmu-mir-23ammu-mir-21mmu-mir-27bMylk3mmu-mir-27bmmu-mir-103-2mmu-mir-27bMapk8Map2k3mmu-mir-195-1Chukmmu-let-7bPdpk1Hdac4mmu-mir-195mmu-mir-195mmu-mir-195mmu-mir-199a-1mmu-let-7bmmu-mir-130bmmu-mir-23ammu-mir-199a-1Mapk1mmu-mir-15bPrkg1Gata4Ctf1Pik3r3Ikbkbmmu-mir-27bmmu-mir-195mmu-mir-199a-2AgtMapk14mmu-mir-27bmmu-mir-30eNfkb1mmu-mir-140Mapk3Pik3cbPpp3cammu-mir-27bDAGmmu-mir-15bmmu-mir-199a-1Wnt5aGsk3bHdac5mmu-mir-195mmu-mir-125b-1mmu-mir-23ammu-mir-125b-1CalmodulinMapk3Ctnnb1Cyclic GMPIP3mmu-mir-199a-2TnfMap2k7Akt1Hdac9Pik3r1mmu-mir-21Map3k14mmu-mir-21sPla2-IIAmmu-mir-15bEif2b5Nppbmmu-mir-15bmmu-mir-199a-1Fgf2Rac1mmu-mir-15bHdac5mmu-mir-23aMapk3Mapk14Mapk7Hdac7Nrg1Wnt3aFgfr2Hdac9mmu-mir-195mmu-mir-185Ikbkgmmu-mir-15bmmu-mir-133a-2


This pathway shows the role of microRNAs in the process of cardiac hypertrophy.

Converted from the humane pathway. MicroRNA targets were predicted by the TargetScan algorithm, and the predicted interactions are shown in red, dashed lines. MicroRNAs are shown as purple rounded rectangles.

It is not sure which WNT and frizzled proteins influence cardiac hypertrophy. Though there are strong indications that WNT3A, WNT5A, frizzled1 and frizzled2 play a role in cardiac hypertrophy. Thus these have been added to the pathway instead of all the WNT and frizzled proteins. Experiments which will shed light on this are still being done.


This pathway was inferred from Homo sapiens pathway WP1544(r37553) with a 96% conversion rate.

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Ontology Terms



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  1. Heineke J, Molkentin JD; ''Regulation of cardiac hypertrophy by intracellular signalling pathways.''; Nat Rev Mol Cell Biol, 2006 PubMed Europe PMC Scholia
  2. Carè A, Catalucci D, Felicetti F, Bonci D, Addario A, Gallo P, Bang ML, Segnalini P, Gu Y, Dalton ND, Elia L, Latronico MV, Høydal M, Autore C, Russo MA, Dorn GW 2nd, Ellingsen O, Ruiz-Lozano P, Peterson KL, Croce CM, Peschle C, Condorelli G; ''MicroRNA-133 controls cardiac hypertrophy.''; Nat Med, 2007 PubMed Europe PMC Scholia
  3. Clerk A, Sugden PH; ''Small guanine nucleotide-binding proteins and myocardial hypertrophy.''; Circ Res, 2000 PubMed Europe PMC Scholia
  4. Vanhaesebroeck B, Alessi DR; ''The PI3K-PDK1 connection: more than just a road to PKB.''; Biochem J, 2000 PubMed Europe PMC Scholia
  5. Wang J, Xu R, Lin F, Zhang S, Zhang G, Hu S, Zheng Z; ''MicroRNA: novel regulators involved in the remodeling and reverse remodeling of the heart.''; Cardiology, 2009 PubMed Europe PMC Scholia
  6. Molkentin JD; ''Calcineurin and beyond: cardiac hypertrophic signaling.''; Circ Res, 2000 PubMed Europe PMC Scholia
  7. Wollert KC, Taga T, Saito M, Narazaki M, Kishimoto T, Glembotski CC, Vernallis AB, Heath JK, Pennica D, Wood WI, Chien KR; ''Cardiotrophin-1 activates a distinct form of cardiac muscle cell hypertrophy. Assembly of sarcomeric units in series VIA gp130/leukemia inhibitory factor receptor-dependent pathways.''; J Biol Chem, 1996 PubMed Europe PMC Scholia
  8. Lim HW, Molkentin JD; ''Calcineurin and human heart failure.''; Nat Med, 1999 PubMed Europe PMC Scholia
  9. Bueno OF, De Windt LJ, Tymitz KM, Witt SA, Kimball TR, Klevitsky R, Hewett TE, Jones SP, Lefer DJ, Peng CF, Kitsis RN, Molkentin JD; ''The MEK1-ERK1/2 signaling pathway promotes compensated cardiac hypertrophy in transgenic mice.''; EMBO J, 2000 PubMed Europe PMC Scholia
  10. Jalili T, Takeishi Y, Walsh RA; ''Signal transduction during cardiac hypertrophy: the role of G alpha q, PLC beta I, and PKC.''; Cardiovasc Res, 1999 PubMed Europe PMC Scholia
  11. Takeishi Y, Ping P, Bolli R, Kirkpatrick DL, Hoit BD, Walsh RA; ''Transgenic overexpression of constitutively active protein kinase C epsilon causes concentric cardiac hypertrophy.''; Circ Res, 2000 PubMed Europe PMC Scholia
  12. Olson EN, Molkentin JD; ''Prevention of cardiac hypertrophy by calcineurin inhibition: hope or hype?''; Circ Res, 1999 PubMed Europe PMC Scholia
  13. Haghikia A, Stapel B, Hoch M, Hilfiker-Kleiner D; ''STAT3 and cardiac remodeling.''; Heart Fail Rev, 2010 PubMed Europe PMC Scholia
  14. Blankesteijn WM, van de Schans VA, ter Horst P, Smits JF; ''The Wnt/frizzled/GSK-3 beta pathway: a novel therapeutic target for cardiac hypertrophy.''; Trends Pharmacol Sci, 2008 PubMed Europe PMC Scholia
  15. Molkentin JD, Lu JR, Antos CL, Markham B, Richardson J, Robbins J, Grant SR, Olson EN; ''A calcineurin-dependent transcriptional pathway for cardiac hypertrophy.''; Cell, 1998 PubMed Europe PMC Scholia
  16. Wollert KC, Chien KR; ''Cardiotrophin-1 and the role of gp130-dependent signaling pathways in cardiac growth and development.''; J Mol Med, 1997 PubMed Europe PMC Scholia
  17. Wang Y, Su B, Sah VP, Brown JH, Han J, Chien KR; ''Cardiac hypertrophy induced by mitogen-activated protein kinase kinase 7, a specific activator for c-Jun NH2-terminal kinase in ventricular muscle cells.''; J Biol Chem, 1998 PubMed Europe PMC Scholia


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106855view13:33, 17 September 2019MaintBotHMDB identifier normalization
70037view02:02, 12 July 2013AlexanderPicoModified title
69898view19:27, 11 July 2013MaintBotupdating to 2013 schema
67464view11:05, 26 June 2013DdiglesOntology Term : 'hypertrophic cardimyopathy pathway' added !
41377view00:28, 2 March 2011MaintBotRemoved redundant pathway information and comments
37650view09:39, 16 June 2010MLevelsEdited Line
37649view08:00, 16 June 2010MLevelsID
37634view14:40, 14 June 2010MLevelsMicroRNA IDs
37633view14:38, 14 June 2010MLevelsMicroRNA IDs
37632view14:33, 14 June 2010MLevelsIDs of microRNAs converted to mouse
37629view14:26, 14 June 2010MLevelsPeriodical save, work in progress
37628view14:16, 14 June 2010MLevelsPeriodical save, work in progress
37625view14:05, 14 June 2010MLevelsPeriodical save, work in progress
37623view13:55, 14 June 2010MLevelsPeriodical save, work in progress
37613view11:26, 14 June 2010MLevelsSpecify description
37612view11:24, 14 June 2010MLevelsPeriodical save, work in progress
37609view10:54, 14 June 2010MLevelsModified description
37608view10:53, 14 June 2010MLevelsChanged Lines, corrected IDs
37607view10:45, 14 June 2010MLevelsPeriodical save, work in progress
37606view10:34, 14 June 2010MLevelsPeriodical save, work in progress
37605view10:13, 14 June 2010MLevelsModified description
37568view18:09, 11 June 2010MaintBotNew pathway

External references


View all...
NameTypeDatabase referenceComment
AgtGeneProduct11606 (Entrez Gene)
Akt1GeneProduct11651 (Entrez Gene)
Akt2GeneProduct11652 (Entrez Gene)
CaMProtein12313 (Entrez Gene)
CalciumMetaboliteHMDB0000464 (HMDB)
Camk2dGeneProduct108058 (Entrez Gene)
Cdk7GeneProduct12572 (Entrez Gene)
Cdk9GeneProduct107951 (Entrez Gene)
ChukGeneProduct12675 (Entrez Gene)
CishGeneProduct12700 (Entrez Gene)
Ctf1GeneProduct13019 (Entrez Gene)
Ctnnb1GeneProduct12387 (Entrez Gene)
Cyclic GMPMetaboliteHMDB0001314 (HMDB)
DAGMetaboliteHMDB0007009 (HMDB)
Dvl1GeneProduct13542 (Entrez Gene)
Edn1GeneProduct13614 (Entrez Gene)
EgfGeneProduct13645 (Entrez Gene)
Eif2b5GeneProduct224045 (Entrez Gene)
Fgf2GeneProduct14173 (Entrez Gene)
Fgfr2GeneProduct14183 (Entrez Gene)
Fzd1GeneProduct14362 (Entrez Gene)
Fzd2GeneProduct57265 (Entrez Gene)
Gata4GeneProduct14463 (Entrez Gene)
Gsk3bGeneProduct56637 (Entrez Gene)
Hdac4GeneProduct208727 (Entrez Gene)
Hdac5GeneProduct15184 (Entrez Gene)
Hdac7GeneProduct56233 (Entrez Gene)
Hdac9GeneProduct79221 (Entrez Gene)
IP3MetaboliteHMDB0001498 (HMDB)
Igf1GeneProduct16000 (Entrez Gene)
Igf1rGeneProduct16001 (Entrez Gene)
IkbkbGeneProduct16150 (Entrez Gene)
IkbkeGeneProduct56489 (Entrez Gene)
IkbkgGeneProduct16151 (Entrez Gene)
Il6stGeneProduct16195 (Entrez Gene)
LifGeneProduct16878 (Entrez Gene)
Lrp5GeneProduct16973 (Entrez Gene)
Lrp6GeneProduct16974 (Entrez Gene)
Map2k1GeneProduct26395 (Entrez Gene)
Map2k2GeneProduct26396 (Entrez Gene)
Map2k3GeneProduct26397 (Entrez Gene)
Map2k4GeneProduct26398 (Entrez Gene)
Map2k5GeneProduct23938 (Entrez Gene)
Map2k6GeneProduct26399 (Entrez Gene)
Map2k7GeneProduct26400 (Entrez Gene)
Map3k14GeneProduct53859 (Entrez Gene)
Map3k7ip1GeneProduct66513 (Entrez Gene)
Mapk1GeneProduct26413 (Entrez Gene)
Mapk14GeneProduct26416 (Entrez Gene)
Mapk3GeneProduct26417 (Entrez Gene)
Mapk4GeneProduct225724 (Entrez Gene)
Mapk7GeneProduct23939 (Entrez Gene)
Mapk8GeneProduct26419 (Entrez Gene)
MtorGeneProduct56717 (Entrez Gene)
Myef2GeneProduct17876 (Entrez Gene)
MylkGeneProduct107589 (Entrez Gene)
Mylk3GeneProduct213435 (Entrez Gene)
Nfatc4GeneProduct73181 (Entrez Gene)
Nfkb1GeneProduct18033 (Entrez Gene)
NppaGeneProduct230899 (Entrez Gene)
NppbGeneProduct18158 (Entrez Gene)
Nrg1GeneProduct211323 (Entrez Gene)
Pdpk1GeneProduct18607 (Entrez Gene)
Pik3caGeneProduct18706 (Entrez Gene)
Pik3cbGeneProduct74769 (Entrez Gene)
Pik3cdGeneProduct18707 (Entrez Gene)
Pik3cgGeneProduct30955 (Entrez Gene)
Pik3r1GeneProduct18708 (Entrez Gene)
Pik3r2GeneProduct18709 (Entrez Gene)
Pik3r3GeneProduct18710 (Entrez Gene)
Plcb2GeneProduct18796 (Entrez Gene)
Ppp3caGeneProduct19055 (Entrez Gene)
Ppp3cbGeneProduct19056 (Entrez Gene)
PrkcbGeneProduct18751 (Entrez Gene)
Prkg1GeneProduct19091 (Entrez Gene)
Rac1GeneProduct19353 (Entrez Gene)
Raf1GeneProduct110157 (Entrez Gene)
Rcan1GeneProduct54720 (Entrez Gene)
RhoaGeneProduct11848 (Entrez Gene)
Rock1GeneProduct19877 (Entrez Gene)
Rock2GeneProduct19878 (Entrez Gene)
Stat3GeneProduct20848 (Entrez Gene)
Tgfb1GeneProduct21803 (Entrez Gene)
TnfGeneProduct21926 (Entrez Gene)
Wnt3aGeneProduct22416 (Entrez Gene)
Wnt5aGeneProduct22418 (Entrez Gene)
mmu-let-7bRnaMI0000558 (miRBase Sequence)
mmu-mir-103-1RnaMI0000587 (miRBase Sequence)
mmu-mir-103-2RnaMI0000588 (miRBase Sequence)
mmu-mir-125b-1RnaMI0000725 (miRBase Sequence)
mmu-mir-125b-2RnaMI0000152 (miRBase Sequence)
mmu-mir-130bRnaMI0000408 (miRBase Sequence)
mmu-mir-133a-1RnaMI0000159 (miRBase Sequence)
mmu-mir-133a-2RnaMI0000820 (miRBase Sequence)
mmu-mir-133bRnaMI0000821 (miRBase Sequence)
mmu-mir-140RnaMI0000165 (miRBase Sequence)
mmu-mir-15bRnaMI0000140 (miRBase Sequence)
mmu-mir-185RnaMI0000227 (miRBase Sequence)
mmu-mir-195-1RnaMI0000237 (miRBase Sequence)
mmu-mir-195RnaMI0000237 (miRBase Sequence)
mmu-mir-199a-1RnaMI0000241 (miRBase Sequence)
mmu-mir-199a-2RnaMI0000713 (miRBase Sequence)
mmu-mir-208aRnaMI0000555 (miRBase Sequence)
mmu-mir-214RnaMI0000698 (miRBase Sequence)
mmu-mir-21RnaMI0000569 (miRBase Sequence)
mmu-mir-23aRnaMI0000571 (miRBase Sequence)
mmu-mir-27bRnaMI0000142 (miRBase Sequence)
mmu-mir-30eRnaMI0000259 (miRBase Sequence)
sPla2-IIAGeneProduct18780 (Entrez Gene)

Annotated Interactions

No annotated interactions
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