Angiogenesis (Homo sapiens)

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9Target GenesTarget GenesVascular budding throughEPC recruitionVessel StabilizationVascularPermeabilityStabilization of newly formedvesselsCell growth and divisionAttraction of pericytes and SMCsCytoplasmMigrationHREDNAUpregulation proteasesCel replicationCapillary tubule formationProliferation and differentiationof ECs, SMCs and fibroblastsEPC mobilizationBasement membranedegradationHypoxia NucleusSurvivalExtracellularProliferationAng 1FLT1SMAD1ARNTVEGFAAKT1SRCsTIE2NOSPDGFBTIMP3MMP9FAKMMP2HIF1APLCG1VEGFATIE2VEGFR2PDGFBFGFR2TIMP2PI3KHIF1AMAPK1MMP9MMP2PDGFRACBPp38 MAPKAng 1FGF2FGF22, 5, 118, 1394, 6, 71, 2, 10, 122, 32, 34, 6, 78, 137, 94, 6, 72, 32, 5, 111, 2, 10, 124, 6, 74, 6, 72, 5, 111, 2, 10, 1258, 134, 6, 72, 3


This pathway is a concise and simplified version of the basic proteins involved in angiogenesis. The proces is regulated by hyopoxia, which results in the transcription of eg. VEGF1, FGF2, PDGFbeta, MMP9, MMP2 and Ang1. These proteins bind to their receptors and by doing this they initiate different pathways that result in vessel formation. Proteins on this pathway have targeted assays available via the CPTAC Assay Portal

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  1. Millauer B, Wizigmann-Voos S, Schnuerch H, Martinez R, Moller NP, Risau W, Ullrich A; ''High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis.''; Cell, 1993 PubMed Europe PMC Scholia
  2. Kutryk MJ, Stewart DJ; ''Angiogenesis of the heart.''; Microsc Res Tech, 2003 PubMed Europe PMC Scholia
  3. Madeddu P; ''Therapeutic angiogenesis and vasculogenesis for tissue regeneration.''; Exp Physiol, 2005 PubMed Europe PMC Scholia
  4. Renault MA, Losordo DW; ''The matrix revolutions: matrix metalloproteinase, vasculogenesis, and ischemic tissue repair.''; Circ Res, 2007 PubMed Europe PMC Scholia
  5. Novotny NM, Lahm T, Markel TA, Crisostomo PR, Wang M, Wang Y, Tan J, Meldrum DR; ''Angiopoietin-1 in the treatment of ischemia and sepsis.''; Shock, 2009 PubMed Europe PMC Scholia
  6. Burbridge MF, Coge F, Galizzi JP, Boutin JA, West DC, Tucker GC; ''The role of the matrix metalloproteinases during in vitro vessel formation.''; Angiogenesis, 2002 PubMed Europe PMC Scholia
  7. Bergers G, Brekken R, McMahon G, Vu TH, Itoh T, Tamaki K, Tanzawa K, Thorpe P, Itohara S, Werb Z, Hanahan D; ''Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis.''; Nat Cell Biol, 2000 PubMed Europe PMC Scholia
  8. Li J, Wei Y, Liu K, Yuan C, Tang Y, Quan Q, Chen P, Wang W, Hu H, Yang L; ''Synergistic effects of FGF-2 and PDGF-BB on angiogenesis and muscle regeneration in rabbit hindlimb ischemia model.''; Microvasc Res, 2010 PubMed Europe PMC Scholia
  9. ; ''Angiogenesis Pathway'';, 2008
  10. Tomanek RJ, Sandra A, Zheng W, Brock T, Bjercke RJ, Holifield JS; ''Vascular endothelial growth factor and basic fibroblast growth factor differentially modulate early postnatal coronary angiogenesis.''; Circ Res, 2001 PubMed Europe PMC Scholia
  11. Koblizek TI, Weiss C, Yancopoulos GD, Deutsch U, Risau W; ''Angiopoietin-1 induces sprouting angiogenesis in vitro.''; Curr Biol, 1998 PubMed Europe PMC Scholia
  12. Tomanek RJ, Zheng W, Yue X; ''Growth factor activation in myocardial vascularization: therapeutic implications.''; Mol Cell Biochem, 2004 PubMed Europe PMC Scholia
  13. Hellberg C, Ostman A, Heldin CH; ''PDGF and vessel maturation.''; Recent Results Cancer Res, 2010 PubMed Europe PMC Scholia


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118358view13:36, 27 May 2021Mkutmonfixed publication references
118356view13:35, 27 May 2021Mkutmonremoved redundant reference
105882view04:53, 16 August 2019KhanspersModified description
105475view05:21, 8 August 2019KhanspersModified description
95042view01:52, 6 November 2017AlexanderPicoannotated cellular compartments
88983view09:51, 18 August 2016MirellaKalafatiOntology Term : 'regulatory pathway' added !
79949view10:53, 28 April 2015ZariChanged Drosophila ID to human ID for p38 MAPK
78807view09:16, 31 January 2015EgonwAccidental commit; reverting, just in case.
78806view09:15, 31 January 2015EgonwWP254
78805view09:14, 31 January 2015EgonwConnected a dot (by adding an invisible box).
75222view22:04, 9 May 2014Khanspersfixed connections and groups
74474view04:33, 25 April 2014EgonwFixed a PubMed ID.
71713view20:05, 17 October 2013MaintBotUpdated UniProt/TrEMBL data source
63161view20:19, 8 May 2013MaintBotUpdating GPML version
59198view19:08, 22 February 2013MaintBotUpdated Ensembl data source
58504view18:59, 14 February 2013MaintBotModified description
44952view12:37, 6 October 2011MartijnVanIerselOntology Term : 'signaling pathway pertinent to development' added !
42601view20:32, 10 April 2011AlexanderPicoupdated HIF1B to ARNT
42554view14:01, 4 April 2011ToxlabProvided entrez Gene ID for FGFR2
42553view13:43, 4 April 2011ToxlabAdded data base ref to FGF2
41185view23:43, 1 March 2011MaintBotRemoved redundant pathway information and comments
38974view18:27, 25 September 2010AlexanderPicofixed groups, labels and lines
38945view23:09, 24 September 2010KhanspersFixed data nodes
38944view23:03, 24 September 2010KhanspersChanged cell compartments
37853view18:22, 12 July 2010KhanspersModified categories
37640view15:30, 14 June 2010LauraSSpecify description
37639view15:22, 14 June 2010LauraSModified description
37638view15:21, 14 June 2010LauraSModified description
37637view15:05, 14 June 2010LauraSSpecify description
37636view14:55, 14 June 2010LauraSPeriodical save, work in progress
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37631view14:31, 14 June 2010LauraSSpecify description
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37627view14:11, 14 June 2010LauraSSpecify description
37626view14:08, 14 June 2010LauraS14-06-2010
37624view14:00, 14 June 2010LauraS14-06-2010
37622view13:55, 14 June 2010LauraSPeriodical save, work in progress
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37615view12:43, 14 June 2010LauraSPeriodical save, work in progress
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37222view16:00, 22 May 2010LauraSSpecify description
37221view15:29, 22 May 2010LauraSPeriodical save, work in progress
37220view15:19, 22 May 2010LauraSPeriodical save, work in progress
37219view15:09, 22 May 2010LauraSPeriodical save, work in progress
37209view20:27, 21 May 2010LauraSVesselformation

External references


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NameTypeDatabase referenceComment
AKT1GeneProductENSG00000142208 (Ensembl)
ARNTGeneProduct405 (Entrez Gene)
Ang 1GeneProductQ15389 (Uniprot-TrEMBL)
CBPGeneProduct1387 (Entrez Gene)
FAKGeneProductQ05397 (Uniprot-TrEMBL)
FGF2GeneProductENSG00000138685 (Ensembl)
FGFR2GeneProduct2263 (Entrez Gene)
FLT1GeneProductENSG00000102755 (Ensembl)
HIF1AGeneProduct3091 (Entrez Gene)
MAPK1GeneProductENSG00000100030 (Ensembl)
MMP2GeneProductENSG00000100985 (Ensembl)
MMP9GeneProductENSG00000100985 (Ensembl)
NOSGeneProductENSG00000164867 (Ensembl)
PDGFBGeneProductENSG00000100311 (Ensembl)
PDGFRAGeneProductP16234 (Uniprot-TrEMBL)
PI3KGeneProduct5290 (Entrez Gene)
PLCG1GeneProductENSG00000124181 (Ensembl)
SMAD1GeneProductENSG00000170365 (Ensembl)
SRCGeneProductENSG00000197122 (Ensembl)
TIE2GeneProduct7010 (Entrez Gene)
TIMP2GeneProductENSG00000035862 (Ensembl)
TIMP3ProteinENSG00000100234 (Ensembl)
VEGFAGeneProductP15692 (Uniprot-TrEMBL)
VEGFR2GeneProduct3791 (Entrez Gene)
p38 MAPKGeneProduct1432 (Entrez Gene)
sTIE2GeneProduct7010 (Entrez Gene)

Annotated Interactions

No annotated interactions

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