Regulation of Cardiac Hypertrophy by miR-208 (Mus musculus)

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beta-MHCbeta-MHC12miR-208bHypertrophyProlonged PR interval, abberand conductionKnock-outOverexpressionmiR-208aAtrial fibrilationsHopMyostatinmiR-208bGata4Trap1Cx40beta-MHCmiR-208a


MicroRNA-208a regulates cardiac hypertrophy pathways in mice. MicroRNAs are shown in purple. Knock out and overexpression of miR-208a are shown in blue. Processes are shown at the top and include hypertrophy, atrial fibrilation and prolonged PR interval & abberand conduction.

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Ontology Terms



  1. Callis TE, Pandya K, Seok HY, Tang RH, Tatsuguchi M, Huang ZP, Chen JF, Deng Z, Gunn B, Shumate J, Willis MS, Selzman CH, Wang DZ; ''MicroRNA-208a is a regulator of cardiac hypertrophy and conduction in mice.''; J Clin Invest, 2009 PubMed Europe PMC Scholia
  2. Lo CW; ''Role of gap junctions in cardiac conduction and development: insights from the connexin knockout mice.''; Circ Res, 2000 PubMed Europe PMC Scholia


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87631view08:54, 25 July 2016LindarieswijkOntology Term : 'hypertrophic cardiomyopathy pathway' added !
73503view23:11, 29 January 2014KhanspersModified title
69926view19:50, 11 July 2013Mkutmonfixed unconnected lines
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59045view20:46, 21 February 2013MaintBotUpdated Ensembl data source
41320view00:24, 2 March 2011MaintBotRemoved redundant pathway information and comments
36815view08:12, 6 May 2010MLevelsModified categories
36798view11:58, 4 May 2010MLevelsMinor changes
36796view11:53, 4 May 2010SusanPeriodical save, work in progress
36791view10:22, 4 May 2010MLevelsModified description
36790view10:20, 4 May 2010MLevels
36789view10:20, 4 May 2010MLevelsMoved a line
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36787view10:15, 4 May 2010MLevelsModified description
36786view10:14, 4 May 2010MLevelsModified description
36785view10:09, 4 May 2010MLevelsMoving items
36784view10:07, 4 May 2010MLevelsPeriodical save, work in progress
36783view09:57, 4 May 2010MLevelsPeriodical save, work in progress
36782view09:37, 4 May 2010MLevelsPeriodical save, work in progress
36781view09:25, 4 May 2010MLevelsPeriodical save, work in progress
36780view09:06, 4 May 2010MLevelsMoving items
36778view08:56, 4 May 2010SusanSpecify description
36777view08:49, 4 May 2010SusanMinor adaptation
36755view08:19, 28 April 2010SusanPeriodical save, work in progress
36751view13:42, 27 April 2010MLevelsAdded color to the micro RNAs
36750view13:11, 27 April 2010MLevelsAdded Entrez Gene number for miR-208b
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External references


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NameTypeDatabase referenceComment
Cx40Protein14613 (Entrez Gene)
Gata4GeneProduct14463 (Entrez Gene)
HopGeneProduct74318 (Entrez Gene)
MyostatinProtein17700 (Entrez Gene)
Trap1Protein327987 (Entrez Gene)
beta-MHCGeneProduct140781 (Entrez Gene)
miR-208aRnaMI0000555 (miRBase Sequence)
miR-208bRnaENSMUSG00000077928 (Ensembl) MI0005552

Annotated Interactions

No annotated interactions

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