DNA Replication (Mus musculus)

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1-3Cdt1Mcm5Orc complexOriginMcm10Orc3Mcm3Mcm7Orc complexMcm5Cdc6Ubiquitinated Orc1UbiquitinOrc2Mcm2Orc1RFC36Cdt1Degraded by proteasome in cytosolPre-replicative complexRFC38Cdc6RNA primer-DNA primer:origin duplex:PCNADNA polymerase alpha:primase: origin complexMcm 4,6,7 trimer forms andassociates with the replication forkCdt1Mcm2Phosphorylated Cdc6Cdc6Orc complexCdc6Pre-replicative complexDNAPolymerase ARFC37Mcm4Mcm7RNA primer-DNA primerCdt1RFC Heteropentamer:RNA primer-DNA primerPCNA homotrimerOrc5Phosphorylation ofMcm 2-7 complexRNA primer-DNA primerRFC1401. Assembly of the pre-replicative complexp58Orc25. Leading/lagging strand synthesisp70RFC Heteropentamer:RNA primer-DNA primerMcm10UbiquitinMcm4Mcm6Orc2Phosphorylated Orc1Orc3Orc3Degraded byproteasomein cytosolOrc5Cdt1Ubiquitinated Cdc6RNA Primer3. DNA replication initiationp180Mcm6Orc5Processive complexp49GemininOrc42. Activation of the pre-replicative complexOrc complexPrimaseOrc24. Switching of origins to post-replicative stateRFC40Orc complexDNA polymerase alpha:primase: origin complexMcm3Orc3Orc4Mcm6dCTPCdt1PcnaATPOrc3lCdc7ATPdATPRfc1UbcPrim1Prim2Dbf4Rpa2UTPPold3Orc5lADPdGTPMcm5Mcm4Orc2lRfc4Rfc5PoleRfc2Pola2Mcm10GmnnCdc45lOrc1lMcm3RPA4Rpa3dUTPPold4GTPCdc6Orc6lATPADPCdk2ATPOrc4lPola1Rpa1Pold2Mcm7Mcm2Uba52Pold1Pole2CTPRfc3


DNA replication, the basis for biological inheritance, is a fundamental process occurring in all living organisms to copy their DNA. This process is "replication" in that each strand of the original double-stranded DNA molecule serves as template for the reproduction of the complementary strand. Hence, following DNA replication, two identical DNA molecules have been produced from a single double-stranded DNA molecule. Cellular proofreading and error-checking mechanisms ensure near perfect fidelity for DNA replication. Source: [wikipedia:DNA_replication|Wikipedia]


GenMAPP notes 
GenMAPP remarks 
Based on www.reactome.org
This pathway was inferred from Homo sapiens pathway WP466(r21660) with a 72% conversion rate.

Quality Tags

Ontology Terms



  1. Bell SP, Dutta A; ''DNA replication in eukaryotic cells.''; Annu Rev Biochem, 2002 PubMed Europe PMC
  2. Kelly TJ, Brown GW; ''Regulation of chromosome replication.''; Annu Rev Biochem, 2000 PubMed Europe PMC
  3. Cimbora DM, Groudine M; ''The control of mammalian DNA replication: a brief history of space and timing.''; Cell, 2001 PubMed Europe PMC


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107197view14:28, 17 September 2019MaintBotChEBI identifier normalization
106854view13:33, 17 September 2019MaintBotHMDB identifier normalization
69148view18:17, 8 July 2013MaintBotUpdated to 2013 gpml schema
67160view10:14, 26 June 2013Christine ChichesterOntology Term : 'DNA replication pathway' added !
41336view00:25, 2 March 2011MaintBotRemoved redundant pathway information and comments
35196view15:36, 11 February 2010ThomasModified description
35195view15:35, 11 February 2010Thomasadded literature
34403view23:03, 9 December 2009MaintBotAutomatic update of empty xrefs
32866view17:56, 16 September 2009MaintBotAdded xrefs
32350view13:38, 15 August 2009MaintBotFixed text labels
31975view13:09, 14 August 2009MaintBotFixed group labels
31398view20:48, 13 August 2009MaintBotFixed text labels
30825view23:59, 29 July 2009MaintBotConverted from Homo sapiens
20997view11:30, 14 November 2008MaintBot[[Pathway:Mus musculus:DNA replication Reactome]] moved to [[Pathway:WP150]]: Moved to stable identifier
7992view13:46, 7 January 2008MaintBot[[Pathway:Mouse:DNA replication Reactome]] moved to [[Pathway:Mus musculus:DNA replication Reactome]]: Renaming species
7620view16:04, 18 December 2007MaintBotfixed category names
7210view12:33, 4 November 2007MaintBotAdded categories to GPML
19418view22:18, 22 May 2007D.Korengpml file for [[Mouse:DNA_replication_Reactome]]
6430view22:18, 22 May 2007Kdahlquistgpml file for [[Mouse:DNA_replication_Reactome]]

External references


View all...
NameTypeDatabase referenceComment
ADPMetaboliteHMDB01341 (HMDB)
ATPMetaboliteHMDB01532 (HMDB)
CTPMetaboliteHMDB00998 (HMDB)
Cdc45lGeneProduct12544 (Entrez Gene)
Cdc6GeneProduct23834 (Entrez Gene)
Cdc7GeneProduct12545 (Entrez Gene)
Cdk2GeneProduct12566 (Entrez Gene)
Cdt1GeneProduct67177 (Entrez Gene)
Dbf4GeneProduct27214 (Entrez Gene)
GTPMetaboliteHMDB01440 (HMDB)
GmnnGeneProduct57441 (Entrez Gene)
Mcm10GeneProduct70024 (Entrez Gene)
Mcm2GeneProduct17216 (Entrez Gene)
Mcm3GeneProduct17215 (Entrez Gene)
Mcm4GeneProduct17217 (Entrez Gene)
Mcm5GeneProduct17218 (Entrez Gene)
Mcm6GeneProduct17219 (Entrez Gene)
Mcm7GeneProduct17220 (Entrez Gene)
Orc1lGeneProduct18392 (Entrez Gene)
Orc2lGeneProduct18393 (Entrez Gene)
Orc3lGeneProduct50793 (Entrez Gene)
Orc4lGeneProduct26428 (Entrez Gene)
Orc5lGeneProduct26429 (Entrez Gene)
Orc6lGeneProduct56452 (Entrez Gene)
PcnaGeneProduct18538 (Entrez Gene)
Pola1GeneProduct18968 (Entrez Gene)
Pola2GeneProduct18969 (Entrez Gene)
Pold1GeneProduct18971 (Entrez Gene)
Pold2GeneProduct18972 (Entrez Gene)
Pold3GeneProduct67967 (Entrez Gene)
Pold4GeneProduct69745 (Entrez Gene)
PoleGeneProduct18973 (Entrez Gene)
Pole2GeneProduct18974 (Entrez Gene)
Prim1GeneProduct19075 (Entrez Gene)
Prim2GeneProduct19076 (Entrez Gene)
Rfc1GeneProduct19687 (Entrez Gene)
Rfc2GeneProduct19718 (Entrez Gene)
Rfc3GeneProduct69263 (Entrez Gene)
Rfc4GeneProduct106344 (Entrez Gene)
Rfc5GeneProduct72151 (Entrez Gene)
Rpa1GeneProduct68275 (Entrez Gene)
Rpa2GeneProduct19891 (Entrez Gene)
Rpa3GeneProduct68240 (Entrez Gene)
UTPMetabolite17625 (ChEBI)
Uba52GeneProduct22186 (Entrez Gene)
UbcGeneProduct22190 (Entrez Gene)
dATPMetaboliteHMDB01532 (HMDB)
dCTPMetaboliteHMDB00998 (HMDB)
dGTPMetaboliteHMDB01440 (HMDB)
dUTPMetabolite17625 (ChEBI)

Annotated Interactions

No annotated interactions
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