DNA Replication (Mus musculus)

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1-3Processive complexRFC Heteropentamer:RNA primer-DNA primerPCNA homotrimerMcm5Mcm5Orc4p58Ubiquitin3. DNA replication initiationOrc2Mcm7Degraded by proteasome in cytosolRFC140Cdc6Orc complexMcm6Mcm4DNA polymerase alpha:primase: origin complexOriginMcm4Mcm2Phosphorylated Orc1Orc3Orc5p180Cdt1Orc2Cdc6Orc3Mcm10Orc5Cdt1Orc3RFC Heteropentamer:RNA primer-DNA primer5. Leading/lagging strand synthesis4. Switching of origins to post-replicative statep70Orc1RNA primer-DNA primer:origin duplex:PCNAMcm 4,6,7 trimer forms andassociates with the replication forkRNA PrimerOrc complexMcm6Orc complexCdt1p49Mcm10Degraded byproteasomein cytosolMcm3DNAPolymerase ADNA polymerase alpha:primase: origin complexOrc complexRNA primer-DNA primerUbiquitinPhosphorylated Cdc6Mcm2RFC36Mcm3Orc2RFC381. Assembly of the pre-replicative complexCdt1Cdc6Orc complexPre-replicative complexMcm7Cdc6Orc3Ubiquitinated Cdc62. Activation of the pre-replicative complexPrimasePhosphorylation ofMcm 2-7 complexRFC37RNA primer-DNA primerOrc5Orc4Pre-replicative complexGemininOrc2RFC40Ubiquitinated Orc1Cdt1Mcm6Cdc6UbcPrim2Uba52PcnaOrc2lATPGTPPrim1dATPPold2Rfc4ATPRfc2Pola2Orc6lPola1dCTPOrc3lCdt1Rfc5dGTPMcm2CTPRpa1Rpa3Mcm4ADPGmnnMcm10Cdc45lRPA4Orc5lMcm3Orc4lPole2ATPCdc7ADPPoleATPPold1Orc1lMcm5Rfc1Rfc3Pold3Rpa2Dbf4Pold4Mcm7UTPdUTPCdk2


DNA replication, the basis for biological inheritance, is a fundamental process occurring in all living organisms to copy their DNA. This process is "replication" in that each strand of the original double-stranded DNA molecule serves as template for the reproduction of the complementary strand. Hence, following DNA replication, two identical DNA molecules have been produced from a single double-stranded DNA molecule. Cellular proofreading and error-checking mechanisms ensure near perfect fidelity for DNA replication. Source: [wikipedia:DNA_replication|Wikipedia]


GenMAPP notes 
GenMAPP remarks 
Based on www.reactome.org
This pathway was inferred from Homo sapiens pathway WP466(r21660) with a 72% conversion rate.

Quality Tags

Ontology Terms



  1. Bell SP, Dutta A; ''DNA replication in eukaryotic cells.''; Annu Rev Biochem, 2002 PubMed Europe PMC Scholia
  2. Kelly TJ, Brown GW; ''Regulation of chromosome replication.''; Annu Rev Biochem, 2000 PubMed Europe PMC Scholia
  3. Cimbora DM, Groudine M; ''The control of mammalian DNA replication: a brief history of space and timing.''; Cell, 2001 PubMed Europe PMC Scholia


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107197view14:28, 17 September 2019MaintBotChEBI identifier normalization
106854view13:33, 17 September 2019MaintBotHMDB identifier normalization
69148view18:17, 8 July 2013MaintBotUpdated to 2013 gpml schema
67160view10:14, 26 June 2013Christine ChichesterOntology Term : 'DNA replication pathway' added !
41336view00:25, 2 March 2011MaintBotRemoved redundant pathway information and comments
35196view15:36, 11 February 2010ThomasModified description
35195view15:35, 11 February 2010Thomasadded literature
34403view23:03, 9 December 2009MaintBotAutomatic update of empty xrefs
32866view17:56, 16 September 2009MaintBotAdded xrefs
32350view13:38, 15 August 2009MaintBotFixed text labels
31975view13:09, 14 August 2009MaintBotFixed group labels
31398view20:48, 13 August 2009MaintBotFixed text labels
30825view23:59, 29 July 2009MaintBotConverted from Homo sapiens
20997view11:30, 14 November 2008MaintBot[[Pathway:Mus musculus:DNA replication Reactome]] moved to [[Pathway:WP150]]: Moved to stable identifier
7992view13:46, 7 January 2008MaintBot[[Pathway:Mouse:DNA replication Reactome]] moved to [[Pathway:Mus musculus:DNA replication Reactome]]: Renaming species
7620view16:04, 18 December 2007MaintBotfixed category names
7210view12:33, 4 November 2007MaintBotAdded categories to GPML
19418view22:18, 22 May 2007D.Korengpml file for [[Mouse:DNA_replication_Reactome]]
6430view22:18, 22 May 2007Kdahlquistgpml file for [[Mouse:DNA_replication_Reactome]]

External references


View all...
NameTypeDatabase referenceComment
ADPMetaboliteHMDB0001341 (HMDB)
ATPMetaboliteHMDB0001532 (HMDB)
CTPMetaboliteHMDB0000998 (HMDB)
Cdc45lGeneProduct12544 (Entrez Gene)
Cdc6GeneProduct23834 (Entrez Gene)
Cdc7GeneProduct12545 (Entrez Gene)
Cdk2GeneProduct12566 (Entrez Gene)
Cdt1GeneProduct67177 (Entrez Gene)
Dbf4GeneProduct27214 (Entrez Gene)
GTPMetaboliteHMDB0001440 (HMDB)
GmnnGeneProduct57441 (Entrez Gene)
Mcm10GeneProduct70024 (Entrez Gene)
Mcm2GeneProduct17216 (Entrez Gene)
Mcm3GeneProduct17215 (Entrez Gene)
Mcm4GeneProduct17217 (Entrez Gene)
Mcm5GeneProduct17218 (Entrez Gene)
Mcm6GeneProduct17219 (Entrez Gene)
Mcm7GeneProduct17220 (Entrez Gene)
Orc1lGeneProduct18392 (Entrez Gene)
Orc2lGeneProduct18393 (Entrez Gene)
Orc3lGeneProduct50793 (Entrez Gene)
Orc4lGeneProduct26428 (Entrez Gene)
Orc5lGeneProduct26429 (Entrez Gene)
Orc6lGeneProduct56452 (Entrez Gene)
PcnaGeneProduct18538 (Entrez Gene)
Pola1GeneProduct18968 (Entrez Gene)
Pola2GeneProduct18969 (Entrez Gene)
Pold1GeneProduct18971 (Entrez Gene)
Pold2GeneProduct18972 (Entrez Gene)
Pold3GeneProduct67967 (Entrez Gene)
Pold4GeneProduct69745 (Entrez Gene)
PoleGeneProduct18973 (Entrez Gene)
Pole2GeneProduct18974 (Entrez Gene)
Prim1GeneProduct19075 (Entrez Gene)
Prim2GeneProduct19076 (Entrez Gene)
Rfc1GeneProduct19687 (Entrez Gene)
Rfc2GeneProduct19718 (Entrez Gene)
Rfc3GeneProduct69263 (Entrez Gene)
Rfc4GeneProduct106344 (Entrez Gene)
Rfc5GeneProduct72151 (Entrez Gene)
Rpa1GeneProduct68275 (Entrez Gene)
Rpa2GeneProduct19891 (Entrez Gene)
Rpa3GeneProduct68240 (Entrez Gene)
UTPMetaboliteCHEBI:17625 (ChEBI)
Uba52GeneProduct22186 (Entrez Gene)
UbcGeneProduct22190 (Entrez Gene)
dATPMetaboliteHMDB0001532 (HMDB)
dCTPMetaboliteHMDB0000998 (HMDB)
dGTPMetaboliteHMDB0001440 (HMDB)
dUTPMetaboliteCHEBI:17625 (ChEBI)

Annotated Interactions

No annotated interactions
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