Fatty Acid Biosynthesis, Initial Steps (Saccharomyces cerevisiae)

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NADPH+D-3-hydroxy-acyl-ACPH+ACP-SHNADPACP-SHCO2ACP-SHmalonyl-ACPbutryl-ACPBCCP-biotin-CO2H2Oacetyl-ACPacetoacetyl-ACPBCCP-biotintrans-delta2-enoyl-acyl-ACPCO2BCCP-biotinADPFAS2FAS2ACC1MCT1Coenzyme AFAS1CEM1ATPacetyl-CoAFAS1NADPHphosphateCoenzyme AOAR1HFA1ATPFAS1ADPphosphateNADPHFAS1ACC1malonyl-CoA


Pyridoxal phosphate (PLP) is the active form of vitamin B6 and is a cofactor in many reactions of amino acid metabolism. Pyridoxine (PN), pyridoxamine (PM), pyridoxal (PL), pyridoxine 5'-phosphate (PNP) and pyridoxamine 5'-phosphate (PMP) are all forms of vitamin B6 that can be converted to PLP via the PLP salvage pathway. Most unicellular organisms and plants can synthesize PLP, whereas mammals cannot and require vitamin B6 in their diet. Thus far, three PLP biosynthetic pathways have been characterized: the de novo PLP biosynthesis pathway as characterized in Escherichia coli (CITS: [12686115]), the de novo PLP biosynthesis pathway as being studied in fungi (CITS: [15483325],[14764090]), and the PLP salvage pathway (CITS: [15483325], [17696614],[8764513],[9537380]). Saccharomyces cerevisiae synthesize PLP via the fungal type de novo PLP synthesis pathway and the PLP salvage pathway (CITS: [7896706], [17696614], [15483325], [14764090]). Extracellular PN, PL and PM are transported into the cell by Tpn1p, a member of the purine-cytosine permease family (CITS: [12649274]). SOURCE: SGD pathways, http://pathway.yeastgenome.org/server.html


GenMAPP remarks 
Based on http://pathway.yeastgenome.org/biocyc/

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89681view06:15, 25 September 2016EgonwReplace the CAS number of the salt with that of just the metabolite.
69759view11:03, 11 July 2013EgonwMarked a few DataNodes with CAS registry numbers as metabolites.
69585view20:29, 8 July 2013MaintBotUpdated to 2013 gpml schema
67243view10:25, 26 June 2013Christine ChichesterOntology Term : 'fatty acid biosynthetic pathway' added !
41811view04:48, 2 March 2011MaintBotRemoved redundant pathway information and comments
36635view22:35, 9 April 2010MaintBotDescription and bibliography added from SGD
20971view11:30, 14 November 2008MaintBot[[Pathway:Saccharomyces cerevisiae:Fatty Acid Biosynthesis Initial Steps]] moved to [[Pathway:WP137]]: Moved to stable identifier
12698view07:58, 17 May 2008MaintBotautomated metabolite conversion
8705view14:07, 7 January 2008MaintBotAdded to category $category
8703view14:07, 7 January 2008M.BraymerUploaded new pathway

External references


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NameTypeDatabase referenceComment
ACC1GeneProductS000005299 (SGD)
ADPMetabolite58-64-0 (CAS)
ATPMetabolite1927-31-7 (CAS)
CEM1GeneProductS000000863 (SGD)
Coenzyme AMetabolite64885-97-8 (CAS)
FAS1GeneProductS000001665 (SGD)
FAS2GeneProductS000006152 (SGD)
HFA1GeneProductS000004820 (SGD)
MCT1GeneProductS000005747 (SGD)
NADPHMetabolite53-57-6 (CAS)
OAR1GeneProductS000001538 (SGD)
acetyl-CoAMetabolite72-89-9 (CAS)
malonyl-CoAMetabolite524-14-1 (CAS)
phosphateMetabolite14265-44-2 (CAS)

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