IL-6 Signaling Pathway (Rattus norvegicus)

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Gene SymbolEndoplasmic reticulumActivationPalmitoylationERDSumoylationCytoplasmPMDGolgi apparatusDemethylationECCY->NUCY->NUProteolytic cleavageMolecular associationRecruitmentDDNucleusGODephosphorylationDDDDeacetylationReactions through unknown mechanisms/moleculesDMethylationEN(Protein-Protein interaction)Early EndosomesCY->NUUbiquitinationReceptorAccession Number: NetPath 18DCY->NUDControlEndosomeExtracellularDMolecule in the pathwayAutophosphorylationPhosphorylationMTMitochondrionDDNULigandCY->ENDesumoylationAcetylationDeubiquitinationEnzyme complexProteins in a complex interactionComplex formationCY->NUCYTranslocationDPlasma membraneGlycosylationCY->NUInhibitionEif4eHspb1JunEp300Il6stHrasPik3r1Il6stCdk9Ppp2r2aPpp2r1bStat1Pik3r2Plcg1Stat3Ncoa1Ppp2cbPpp2r5eRps6ka2Shc1Raf1Foxo1aStat3HckNfkb1CebpbMaptMap3k7Map3k4Grb2PrkcdStat3Stat3RGD1564385Map2k1Foxo3aCdk5Eif2aPPP2R3BTecPtk2Inpp5dRGD1561602PxnMapk1Stat3Tcf1Nfkb1Rb1Ppp2r5aPtpn11Sos1Rac1Mapk3Akt1Map3k7Erbb2Eif4ebp1Il6raVav1Jak1Ppp2r2bStat1Stat5aLynSgkRps6kb1Mapk14Stat1SgkRGD1565643Il6Map2k4BtkFosFgrTyk2Il6raMapk14Ppp2r2cIl6Gab1RGD1561201ArStat1CebpbStat3Ppp2r3aHspcaCdk5r1PPP2R5CJak2Mapk8Ppp2r4Ppp2r5bStat5bPpp2r1aCasp9Ptk2bMap2k2Gsk3bDaxxSocs3Erbb3Ppp2caHdac1Map2k6FynStat3Mapkapk2Inppl1Gab2Ppp2r5dCasp3BadTnfrsf5Stat3Crebbp


Description

No description

Comments

GenMAPP notes 
NetPath 18 - IL-6 signaling pathway. NetPath (http://www.netpath.org) is a collaborative project between PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and the Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the NetPath website until the pathway is published.
GenMAPP remarks 
http://www.netpath.org

Quality Tags

Ontology Terms

 

Bibliography

No bibliography


History

View all...
CompareRevisionActionTimeUserComment
83583view07:23, 26 November 2015EgonwAdded two missing gene identifiers.
83528view19:53, 20 November 2015Khanspersupdated missing ids
82974view23:24, 16 November 2015MkutmonUpdated identifiers
82865view16:04, 10 November 2015JmeliusCorrect outdated id
69356view18:53, 8 July 2013MaintBotUpdated to 2013 gpml schema
67383view10:45, 26 June 2013Christine ChichesterOntology Term : 'interleukin-6 signaling pathway' added !
41668view02:35, 2 March 2011MaintBotRemoved redundant pathway information and comments
28140view23:55, 27 January 2009KhanspersChanged name
20965view11:30, 14 November 2008MaintBot[[Pathway:Rattus norvegicus:IL-6 NetPath 18]] moved to [[Pathway:WP135]]: Moved to stable identifier
8192view13:46, 7 January 2008MaintBot[[Pathway:Rat:IL-6 NetPath 18]] moved to [[Pathway:Rattus norvegicus:IL-6 NetPath 18]]: Renaming species
7716view16:12, 18 December 2007MaintBotfixed category names
7255view12:41, 4 November 2007MaintBotAdded categories to GPML
6563view22:20, 22 May 2007A.Pandeygpml file for [[Rat:IL-6_NetPath_18]]

External references

DataNodes

View all...
NameTypeDatabase referenceComment
Akt1GeneProduct24185 (Entrez Gene)
ArGeneProduct24208 (Entrez Gene)
BadGeneProduct64639 (Entrez Gene)
BtkGeneProduct367901 (Entrez Gene)
Casp3GeneProduct25402 (Entrez Gene)
Casp9GeneProduct58918 (Entrez Gene)
Cdk5GeneProduct140908 (Entrez Gene)
Cdk5r1GeneProduct116671 (Entrez Gene)
Cdk9GeneProduct362110 (Entrez Gene)
CebpbGeneProduct24253 (Entrez Gene)
CrebbpGeneProduct54244 (Entrez Gene)
DaxxGeneProduct140926 (Entrez Gene)
Eif2aGeneProduct502531 (Entrez Gene)
Eif4eGeneProduct117045 (Entrez Gene)
Eif4ebp1GeneProduct116636 (Entrez Gene)
Ep300GeneProduct170915 (Entrez Gene)
Erbb2GeneProduct24337 (Entrez Gene)
Erbb3GeneProduct29496 (Entrez Gene)
FgrGeneProduct79113 (Entrez Gene)
FosGeneProduct314322 (Entrez Gene)
Foxo1aGeneProduct84482 (Entrez Gene)
Foxo3aGeneProduct294515 (Entrez Gene)
FynGeneProduct25150 (Entrez Gene)
Gab1GeneProduct361388 (Entrez Gene)
Gab2GeneProduct84477 (Entrez Gene)
Grb2GeneProduct81504 (Entrez Gene)
Gsk3bGeneProduct84027 (Entrez Gene)
HckGeneProduct25734 (Entrez Gene)
Hdac1GeneProduct297893 (Entrez Gene)
HrasGeneProduct293621 (Entrez Gene)
Hspb1GeneProduct24471 (Entrez Gene)
HspcaGeneProduct299331 (Entrez Gene)
Il6GeneProduct24498 (Entrez Gene)
Il6raGeneProductENSRNOG00000020811 (Ensembl)
Il6stGeneProduct25205 (Entrez Gene)
Inpp5dGeneProduct54259 (Entrez Gene)
Inppl1GeneProduct65038 (Entrez Gene)
Jak1GeneProduct84598 (Entrez Gene)
Jak2GeneProduct24514 (Entrez Gene)
JunGeneProduct24516 (Entrez Gene)
LynGeneProduct81515 (Entrez Gene)
Map2k1GeneProduct170851 (Entrez Gene)
Map2k2GeneProduct58960 (Entrez Gene)
Map2k4GeneProduct287398 (Entrez Gene)
Map2k6GeneProduct114495 (Entrez Gene)
Map3k4GeneProduct308106 (Entrez Gene)
Map3k7GeneProduct313121 (Entrez Gene)
Mapk1GeneProduct116590 (Entrez Gene)
Mapk14GeneProduct81649 (Entrez Gene)
Mapk3GeneProduct50689 (Entrez Gene)
Mapk8GeneProduct116554 (Entrez Gene)
Mapkapk2GeneProduct289014 (Entrez Gene)
MaptGeneProductENSRNOG00000005133 (Ensembl)
Ncoa1GeneProduct313929 (Entrez Gene)
Nfkb1GeneProduct81736 (Entrez Gene)
PPP2R3BGeneProduct682033 (Entrez Gene)
PPP2R5CGeneProduct691318 (Entrez Gene)
Pik3r1GeneProduct25513 (Entrez Gene)
Pik3r2GeneProduct29741 (Entrez Gene)
Plcg1GeneProduct25738 (Entrez Gene)
Ppp2caGeneProduct24672 (Entrez Gene)
Ppp2cbGeneProduct24673 (Entrez Gene)
Ppp2r1aGeneProduct117281 (Entrez Gene)
Ppp2r1bGeneProduct315648 (Entrez Gene)
Ppp2r2aGeneProduct117104 (Entrez Gene)
Ppp2r2bGeneProduct60660 (Entrez Gene)
Ppp2r2cGeneProductENSRNOG00000058202 (Ensembl)
Ppp2r3aGeneProduct363122 (Entrez Gene)
Ppp2r4GeneProduct362102 (Entrez Gene)
Ppp2r5aGeneProduct312754 (Entrez Gene)
Ppp2r5bGeneProduct309179 (Entrez Gene)
Ppp2r5dGeneProductENSRNOG00000016849 (Ensembl)
Ppp2r5eGeneProduct299147 (Entrez Gene)
PrkcdGeneProduct170538 (Entrez Gene)
Ptk2GeneProduct25614 (Entrez Gene)
Ptk2bGeneProduct50646 (Entrez Gene)
Ptpn11GeneProduct25622 (Entrez Gene)
PxnGeneProduct360820 (Entrez Gene)
RGD1561201GeneProduct302415 (Entrez Gene)
RGD1561602GeneProduct497961 (Entrez Gene)
RGD1564385GeneProduct361597 (Entrez Gene)
RGD1565643GeneProduct367786 (Entrez Gene)
Rac1GeneProduct363875 (Entrez Gene)
Raf1GeneProduct24703 (Entrez Gene)
Rb1GeneProduct24708 (Entrez Gene)
Rps6ka2GeneProduct117269 (Entrez Gene)
Rps6kb1GeneProduct83840 (Entrez Gene)
SgkGeneProduct29517 (Entrez Gene)
Shc1GeneProduct85385 (Entrez Gene)
Socs3GeneProduct89829 (Entrez Gene)
Sos1GeneProduct313845 (Entrez Gene)
Stat1GeneProduct25124 (Entrez Gene)
Stat3GeneProduct25125 (Entrez Gene)
Stat5aGeneProduct24918 (Entrez Gene)
Stat5bGeneProduct25126 (Entrez Gene)
Tcf1GeneProduct24817 (Entrez Gene)
TecGeneProduct84492 (Entrez Gene)
Tnfrsf5GeneProduct171369 (Entrez Gene)
Tyk2GeneProductENSRNOG00000032948 (Ensembl)
Vav1GeneProduct25156 (Entrez Gene)

Annotated Interactions

No annotated interactions
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