Selenium metabolism Selenoproteins (Danio rerio)

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2, 3, 6-10SecsynthesisSe transportand storageSec tRNA[ser]secORGANIC SeGSHSelenocysteyl-tRNA secSeCBody proteinsProtein foldingAntioxidantenzymesThyroid hormonemetabolismDietSeCSe = Selenium, SeMet = SelenoMethionine, SeC = Selcysteine, H2Se = Selenide, GSH = gluthatione, Trx = Thioredoxincoding regionSelenoproteinsdemethylationnucleusSTOPTranscription FactorsRedoxsignallingmethyl transferaseINORGANIC SeSeC BiosynthesisSelenium binding proteinsPhosphoseryl-tRNA[ser](sec)TrXAUGSeryl-tRNA[ser](sec)UnkownfunctionSeCselt1azgc:136970Cystathionine g-lyasesepx1fosSephs1Sephs2junCremUGAsp3Pouf2f1sars2TXNRD3SBP2GPX6SelenateSep15PstkMethylSelenol MeSeHeefsecSeleniteSelVrpl30SeMetsepmdio1LOC557632gpx4aSp1relatrnau1aplTXNRD2Nfe2l2zgc:103591sps2GPX2sepw1DIO3H2SeTXNRD3GPX3sephSelenophosphatefabp1aTXNRD1SelenatesepsecsSBP2selenbp1SeCNFKB-p105dio2GPX1eefsecsepn1si:ch211-15i6.2SeleniteSBP2sepp1aTXNRD2zgc:171514SarsSeMetTXNRD11, 4, 114, 5


* Comments belonging to specific genes on the Selenoprotein pathway
    • TRXND3 gene: Although the geneID is correct, the sequence of this gene was guessed by analogy.
    • Cystathionine gamma-lyase is the mammalian form of bacterial methionine gamma-lyase
    • A selenoprotein database exists at:


This pathway was inferred from Homo sapiens pathway WP28(r30051) with a 50% conversion rate.

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Ontology Terms



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  1. Wang H, Zhang J, Yu H; ''Elemental selenium at nano size possesses lower toxicity without compromising the fundamental effect on selenoenzymes: comparison with selenomethionine in mice.''; Free Radic Biol Med, 2007 PubMed
  2. Xu XM, Carlson BA, Mix H, Zhang Y, Saira K, Glass RS, Berry MJ, Gladyshev VN, Hatfield DL; ''Biosynthesis of selenocysteine on its tRNA in eukaryotes.''; PLoS Biol, 2007 PubMed
  3. Papp LV, Lu J, Holmgren A, Khanna KK; ''From selenium to selenoproteins: synthesis, identity, and their role in human health.''; Antioxid Redox Signal, 2007 PubMed
  4. PubMed
  5. Xia Y, Hill KE, Byrne DW, Xu J, Burk RF; ''Effectiveness of selenium supplements in a low-selenium area of China.''; Am J Clin Nutr, 2005 PubMed
  6. Boosalis MG; ''The role of selenium in chronic disease.''; Nutr Clin Pract, 2008 PubMed
  7. Soda K, Oikawa T, Esaki N; ''Vitamin B6 enzymes participating in selenium amino acid metabolism.''; Biofactors, 1999 PubMed
  8. Small-Howard AL, Berry MJ; ''Unique features of selenocysteine incorporation function within the context of general eukaryotic translational processes.''; Biochem Soc Trans, 2005 PubMed
  9. PubMed
  10. Gromer S, Eubel JK, Lee BL, Jacob J; ''Human selenoproteins at a glance.''; Cell Mol Life Sci, 2005 PubMed
  11. Ip C, Hayes C; ''Tissue selenium levels in selenium-supplemented rats and their relevance in mammary cancer protection.''; Carcinogenesis, 1989 PubMed


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87650view08:54, 25 July 2016LindarieswijkOntology Term : 'selenoamino acid metabolic pathway' added !
68638view04:52, 6 July 2013MaintBotUpdated to 2013 gpml schema
62803view17:45, 2 May 2013Mkutmonremove datasource annotations without identifier
62785view16:32, 2 May 2013MaintBotUpdated UniProt data source
58788view22:45, 20 February 2013MaintBotUpdated Ensembl and UniProt data source
40805view22:16, 1 March 2011MaintBotRemoved redundant pathway information and comments
34194view21:26, 9 December 2009MaintBotAutomatic update of empty xrefs
32332view13:29, 15 August 2009MaintBotFixed text labels
31941view12:58, 14 August 2009MaintBotFixed group labels
31371view20:37, 13 August 2009MaintBotFixed text labels
31069view01:28, 30 July 2009MaintBotNew pathway

External references


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NameTypeDatabase referenceComment
Cystathionine g-lyaseGeneProduct
GPX3GeneProduct798788 (Entrez Gene)
LOC557632GeneProduct557632 (Entrez Gene)
MethylSelenol MeSeHMetabolite
Nfe2l2GeneProduct360149 (Entrez Gene)
SarsGeneProduct445405 (Entrez Gene)
SeCMetaboliteHMDB03288 (HMDB)
SeMetMetaboliteHMDB03966 (HMDB)
SelenophosphateMetaboliteHMDB06407 (HMDB)
Sep15GeneProduct352923 (Entrez Gene)
Sephs1GeneProduct324947 (Entrez Gene)
Sp1GeneProduct324109 (Entrez Gene)
TXNRD1GeneProduct352924 (Entrez Gene)
TXNRD3GeneProduct352925 (Entrez Gene)
dio1GeneProduct799937 (Entrez Gene)
dio2GeneProduct352937 (Entrez Gene)
eefsecGeneProduct641497 (Entrez Gene)
fabp1aGeneProduct791610 (Entrez Gene)
fosGeneProductENSDARG00000031683 (Ensembl)
gpx4aGeneProduct352928 (Entrez Gene)
junGeneProductENSDARG00000043531 (Ensembl)
relaGeneProduct415099 (Entrez Gene)
rpl30GeneProduct336713 (Entrez Gene)
sars2GeneProduct394154 (Entrez Gene)
selenbp1GeneProduct393542 (Entrez Gene)
selt1aGeneProduct352919 (Entrez Gene)
sephGeneProduct347743 (Entrez Gene)
sepmGeneProduct352913 (Entrez Gene)
sepn1GeneProduct352914 (Entrez Gene)
sepp1aGeneProduct352931 (Entrez Gene)
sepsecsGeneProduct393123 (Entrez Gene)
sepw1GeneProduct352915 (Entrez Gene)
sepx1GeneProduct352916 (Entrez Gene)
si:ch211-15i6.2GeneProduct558648 (Entrez Gene)
sp3GeneProduct558652 (Entrez Gene)
sps2GeneProduct352933 (Entrez Gene)
trnau1aplGeneProduct791478 (Entrez Gene)
zgc:103591GeneProduct791738 (Entrez Gene)
zgc:136970GeneProduct735249 (Entrez Gene)
zgc:171514GeneProduct559537 (Entrez Gene)

Annotated Interactions

No annotated interactions
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