Apoptosis (Danio rerio)

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135CaspActivator of Cell DeathpFas LigandpApoptosisDNA FragmentationDegradationbbeMitochondrionIGF1R signaling pathwaybInterferon regulatory factorsep53 RelatedInhibitor of Cell DeathPMAIP1MIR29B1MIR29Acasp9mdm2BAK1traf3txndc15nfkb1fasbirc2diabloaakt1si:ch211-165b19.5tnfrsf21badanfkbiabzgc:171731ripk1lirf2anfkbibtnfbzgc:171731irf6casp3bprf1.2tnfrsf1aigf1rarelachukBX511080.1apaf1tnfrsf1bCASP10birc2BIDsi:ch211-112c15.8mapk10traf1ikbkbirf5dffacycsanfkbibBBC3irf3casp2HRKtp73scaf11casp7mycatnfbigf2acraddikbkgbokaunm_sa808cflaraBCL2L2pik3r1traddbirc5aigf1tnfrsfajunbnip3ladffbtraddbcl2atnfrsf1airf7relabcl2l1irf4bnfkbietp532map2k4aripk1lcdkn2a/bcasp8l1xiapbadanfkbiabfaslgtnfsf10nfkbiehellsnfkb1faddmcl1acasp6BCL2L11map3k1tp63MIR29B2


Description

Apoptosis is a distinct form of cell death that is functionally and morphologically different from necrosis. Nuclear chromatin condensation, cytoplasmic shrinking, dilated endoplasmic reticulum, and membrane blebbing characterize apoptosis in general. Mitochondria remain morphologically unchanged. In 1972 Kerr et al introduced the concept of apoptosis as a distinct form of "cell-death", and the mechanisms of various apoptotic pathways are still being revealed today.

Comments

HomologyMapper 
This pathway was inferred from Homo sapiens pathway WP254 (r95107) with a 88.0% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

  1. Mott JL, Kobayashi S, Bronk SF, Gores GJ; ''mir-29 regulates Mcl-1 protein expression and apoptosis.''; Oncogene, 2007 PubMed Europe PMC Scholia
  2. Lakin ND, Jackson SP; ''Regulation of p53 in response to DNA damage.''; Oncogene, 1999 PubMed Europe PMC Scholia
  3. Park SY, Lee JH, Ha M, Nam JW, Kim VN; ''miR-29 miRNAs activate p53 by targeting p85 alpha and CDC42.''; Nat Struct Mol Biol, 2009 PubMed Europe PMC Scholia
  4. Xiong Y, Fang JH, Yun JP, Yang J, Zhang Y, Jia WH, Zhuang SM; ''Effects of microRNA-29 on apoptosis, tumorigenicity, and prognosis of hepatocellular carcinoma.''; Hepatology, 2010 PubMed Europe PMC Scholia
  5. Bose I, Ghosh B; ''The p53-MDM2 network: from oscillations to apoptosis.''; J Biosci, 2007 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
95786view14:37, 19 January 2018MkutmonHomology conversion update
91982view08:13, 11 April 2017LWackersReplaced human genes with zebrafish orthologs where possible; updated old annotations.
87015view14:45, 15 July 2016MkutmonOntology Term : 'apoptotic cell death pathway' added !
71509view19:21, 17 October 2013MaintBotAutomated update of data sources
68635view04:49, 6 July 2013MaintBotUpdated to 2013 gpml schema
47917view21:43, 18 April 2012Khanspersupdated xrefs
40802view22:16, 1 March 2011MaintBotRemoved redundant pathway information and comments
35102view13:09, 11 February 2010MartijnVanIerseladded lit. ref.
34191view21:25, 9 December 2009MaintBotAutomatic update of empty xrefs
31936view12:56, 14 August 2009MaintBotFixed group labels
31061view01:26, 30 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
BAK1GeneProductNo homologues found for original id L:578
BBC3GeneProductNo homologues found for original id L:27113
BCL2L11GeneProductNo homologues found for original id L:10018
BCL2L2GeneProductNo homologues found for original id L:599
BIDGeneProductNo homologues found for original id L:637
BX511080.1GeneProductENSDARG00000089995 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:581
CASP10GeneProductNo homologues found for original id L:843
HRKGeneProductNo homologues found for original id L:8739
MIR29AGeneProduct
MIR29B1GeneProduct
MIR29B2GeneProduct
PMAIP1GeneProductNo homologues found for original id L:5366
akt1GeneProductENSDARG00000099657 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:207
apaf1GeneProductENSDARG00000021239 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:317
badaGeneProductENSDARG00000087993 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:572
bcl2aGeneProductENSDARG00000094704 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:596
bcl2l1GeneProductENSDARG00000008434 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:598
birc2GeneProductENSDARG00000044619 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:330
birc5aGeneProductENSDARG00000075621 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:332
bnip3laGeneProductENSDARG00000025468 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:665
bokaGeneProductENSDARG00000052129 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:666
casp2GeneProductENSDARG00000062052 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:835
casp3bGeneProductENSDARG00000055045 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:836
casp6GeneProductENSDARG00000093405 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:839
casp7GeneProductENSDARG00000091836 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:840
casp8l1GeneProductENSDARG00000058341 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:841
casp9GeneProductENSDARG00000004325 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:842
cdkn2a/bGeneProductENSDARG00000037262 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:1029
cflaraGeneProductENSDARG00000055966 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:8837
chukGeneProductENSDARG00000011662 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:1147
craddGeneProductENSDARG00000028192 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:8738
cycsaGeneProductENSDARG00000095636 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:54205
dffaGeneProductENSDARG00000055770 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:1676
dffbGeneProductENSDARG00000009748 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:1677
diabloaGeneProductENSDARG00000104172 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:56616
faddGeneProductENSDARG00000103021 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:8772
fasGeneProductENSDARG00000043586 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:355
faslgGeneProductENSDARG00000098913 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:356
hellsGeneProductENSDARG00000057738 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:3070
igf1GeneProductENSDARG00000094132 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:3479
igf1raGeneProductENSDARG00000027423 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:3480
igf2aGeneProductENSDARG00000018643 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:3481
ikbkbGeneProductENSDARG00000079123 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:3551
ikbkgGeneProductENSDARG00000017037 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:8517
irf2aGeneProductENSDARG00000007387 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:3660
irf3GeneProductENSDARG00000076251 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:3661
irf4bGeneProductENSDARG00000055374 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:3662
irf5GeneProductENSDARG00000045681 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:3663
irf6GeneProductENSDARG00000101986 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:3664
irf7GeneProductENSDARG00000045661 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:3665
junGeneProductENSDARG00000043531 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:3725
map2k4aGeneProductENSDARG00000063583 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:6416
map3k1GeneProductENSDARG00000098405 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:4214
mapk10GeneProductENSDARG00000102730 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5602
mcl1aGeneProductENSDARG00000009779 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:4170
mdm2GeneProductENSDARG00000033443 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:4193
mycaGeneProductENSDARG00000045695 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:4609
nfkb1GeneProductENSDARG00000105261 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:4790
nfkbiabGeneProductENSDARG00000007693 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:4792
nfkbibGeneProductENSDARG00000030087 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:4793
nfkbieGeneProductENSDARG00000068367 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:4794
pik3r1GeneProductENSDARG00000038524 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5295
prf1.2GeneProductENSDARG00000021444 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5551
relaGeneProductENSDARG00000098696 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5970
ripk1lGeneProductENSDARG00000006677 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:8737
scaf11GeneProductENSDARG00000045885 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:9169
si:ch211-112c15.8GeneProductENSDARG00000089868 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:8718
si:ch211-165b19.5GeneProductENSDARG00000055986 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:3002
tnfbGeneProductENSDARG00000013598 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:7124
tnfrsf1aGeneProductENSDARG00000018569 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:7132
tnfrsf1bGeneProductENSDARG00000070165 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:7133
tnfrsf21GeneProductENSDARG00000001807 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:27242
tnfrsfaGeneProductENSDARG00000004451 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:8795
tnfsf10GeneProductENSDARG00000057241 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:8743
tp53GeneProductENSDARG00000035559 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:7157
tp63GeneProductENSDARG00000044356 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:8626
tp73GeneProductENSDARG00000017953 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:7161
traddGeneProductENSDARG00000036057 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:8717
traf1GeneProductENSDARG00000069482 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:7185
traf3GeneProductENSDARG00000022000 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:7187
txndc15GeneProductENSDARG00000043249 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:3659
unm_sa808GeneProductENSDARG00000078378 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:7186
xiapGeneProductENSDARG00000016143 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:331
zgc:171731GeneProductENSDARG00000014657 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:837

Annotated Interactions

No annotated interactions
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