ErbB signaling pathway (Rattus norvegicus)

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DNA+p+pNo signaling+pMigration / InvasionDNADNAReceptor ubiquitylationMetabolismCellular targetsEndometrialcancerCell survival+pDegradation+pAngiogenesis+p(HER2/Neu)Calcium signaling pathwayMAPK signalingpathwayDifferentiationAdhesionPancreaticCancer(EGFR)ProteinsynthesisAdhesionMigrationGliomamTor signaling pathway+pSurvival+p+pIP3Cellular targetsER+pCa+2DNA+p+p+pActivation by ErbB2overexpression (cancers)+p+pCell cycleDG+pERBB SIGNALING PATHWAYProliferationNon-smallcell lungcancerCell cycleprogression+p+pPIP3+pEgfrAbl1Cdkn1aAREGHbegfCamk2aGsk3bEgfrErbb4Rps6kb1Map2k1Eif4ebp1Plcg1TgfaStat5aPak4Elk1Pik3r5Nck1Erbb3Shc2Nrg2MycCblcJunErbb2BtcHrasMap2k7Erbb2BadCrkErbb2SrcErbb2EgfGrb2Akt3EgfrNrg4Cdkn1bPrkcaMapk8Mapk1Stat5aErbb4Sos1Erbb3Gab1Erbb3Nrg1Ptk2Erbb2Erbb4Grb2MtorNrg3EregArafElk1


The ErbB protein family or epidermal growth factor receptor (EGFR) family is a family of four structurally related receptor tyrosine kinases. Insufficient ErbB signaling in humans is associated with the development of neurodegenerative diseases, such as multiple sclerosis and Alzheimer's Disease. In mice loss of signaling by any member of the ErbB family results in embryonic lethality with defects in organs including the lungs, skin, heart and brain. Excessive ErbB signaling is associated with the development of a wide variety of types of solid tumor. ErbB-1 and ErbB-2 are found in many human cancers and their excessive signaling may be critical factors in the development and malignancy of these tumors.

The ErbB protein family consists of 4 members

   * ErbB-1, also named epidermal growth factor receptor (EGFR)
   * ErbB-2, also named HER2 in humans and neu in rodents
   * ErbB-3, also named HER3 and
   * ErbB-4, also named HER4

The four members of the ErbB protein family are capable of forming homodimers, heterodimers, and possibly higher order oligomers upon activation by a subset of potential growth factor ligands.


This pathway was inferred from Homo sapiens pathway WP673(r29836) with a 98% conversion rate.

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72057view17:16, 24 October 2013Mkutmonupdated annotations for Camk2a and Akt3
69395view18:59, 8 July 2013MaintBotUpdated to 2013 gpml schema
67204view10:20, 26 June 2013Christine ChichesterOntology Term : 'epidermal growth factor/neuregulin signaling pathway' added !
41713view02:38, 2 March 2011MaintBotRemoved redundant pathway information and comments
34092view19:16, 9 December 2009MaintBotAutomatic update of empty xrefs
31337view20:24, 13 August 2009MaintBotFixed text labels
30984view00:54, 30 July 2009MaintBotNew pathway

External references


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NameTypeDatabase referenceComment
AREGGeneProduct29183 (Entrez Gene)
Abl1GeneProduct311860 (Entrez Gene)
Akt3GeneProductENSRNOG00000021497 (Ensembl)
ArafGeneProduct64363 (Entrez Gene)
BadGeneProduct64639 (Entrez Gene)
BtcGeneProduct64022 (Entrez Gene)
Camk2aGeneProductENSRNOG00000018712 (Ensembl)
CblcGeneProduct292699 (Entrez Gene)
Cdkn1aGeneProduct114851 (Entrez Gene)
Cdkn1bGeneProduct83571 (Entrez Gene)
CrkGeneProduct54245 (Entrez Gene)
EgfGeneProduct25313 (Entrez Gene)
EgfrGeneProduct24329 (Entrez Gene)
Eif4ebp1GeneProduct116636 (Entrez Gene)
Elk1GeneProduct314436 (Entrez Gene)
Erbb2GeneProduct24337 (Entrez Gene)
Erbb3GeneProduct29496 (Entrez Gene)
Erbb4GeneProduct59323 (Entrez Gene)
EregGeneProduct59325 (Entrez Gene)
Gab1GeneProduct361388 (Entrez Gene)
Grb2GeneProduct81504 (Entrez Gene)
Gsk3bGeneProduct84027 (Entrez Gene)
HbegfGeneProduct25433 (Entrez Gene)
HrasGeneProduct293621 (Entrez Gene)
JunGeneProduct24516 (Entrez Gene)
Map2k1GeneProduct170851 (Entrez Gene)
Map2k7GeneProduct363855 (Entrez Gene)
Mapk1GeneProduct116590 (Entrez Gene)
Mapk8GeneProduct116554 (Entrez Gene)
MtorGeneProduct56718 (Entrez Gene)
MycGeneProduct24577 (Entrez Gene)
Nck1GeneProduct300955 (Entrez Gene)
Nrg1GeneProduct112400 (Entrez Gene)
Nrg2GeneProduct432361 (Entrez Gene)
Nrg3GeneProduct498596 (Entrez Gene)
Nrg4GeneProduct690919 (Entrez Gene)
Pak4GeneProduct292756 (Entrez Gene)
Pik3r5GeneProduct497931 (Entrez Gene)
Plcg1GeneProduct25738 (Entrez Gene)
PrkcaGeneProduct24680 (Entrez Gene)
Ptk2GeneProduct25614 (Entrez Gene)
Rps6kb1GeneProduct83840 (Entrez Gene)
Shc2GeneProduct314612 (Entrez Gene)
Sos1GeneProduct313845 (Entrez Gene)
SrcGeneProduct83805 (Entrez Gene)
Stat5aGeneProduct24918 (Entrez Gene)
TgfaGeneProduct24827 (Entrez Gene)

Annotated Interactions

No annotated interactions
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