Matrix metalloproteinases (Homo sapiens)

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1OtherStromelysinsGelatinasesEnamelysinMembrane-type MMPsBased on Vu & Werb (2000)Matrix metalloproteinases: effectors of development and normal physiology.Genes Dev 14:2123-2133Potential Inducers of TranscriptionInhibitorsMetalloelastaseCollagenasesMatrilysinMMP27TCF20MMP12MMP11MMP10TIMP3TIMP1BSGMMP19MMP21MMP26MMP23BMMP17MMP14TNFMMP3MMP15MMP2MMP28MMP20MMP16MMP24MMP1MMP23AMMP25TIMP2MMP13MMP8MMP7TIMP4MMP9


Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases; other family members are adamalysins, serralysins, and astacins. The MMPs belong to a larger family of proteases known as the metzincin superfamily.

Collectively they are capable of degrading all kinds of extracellular matrix proteins, but also can process a number of bioactive molecules. They are known to be involved in the cleavage of cell surface receptors, the release of apoptotic ligands (such as the FAS ligand), and chemokine/cytokine in/activation. MMPs are also thought to play a major role on cell behaviors such as cell proliferation, migration (adhesion/dispersion), differentiation, angiogenesis, apoptosis and host defense.

Source: Wikipedia

Proteins on this pathway have targeted assays available via the CPTAC Assay Portal

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Ontology Terms



  1. Vu TH, Werb Z; ''Matrix metalloproteinases: effectors of development and normal physiology.''; Genes Dev, 2000 PubMed Europe PMC Scholia


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117774view13:58, 22 May 2021EweitzModified title
106640view21:03, 12 September 2019KhanspersModified description
105643view05:09, 10 August 2019KhanspersModified description
72054view17:08, 24 October 2013Mkutmonupdated annotation for MMP23A
68949view17:37, 8 July 2013MaintBotUpdated to 2013 gpml schema
67451view11:03, 26 June 2013DdiglesOntology Term : 'cell-extracellular matrix signaling pathway' added !
44892view10:16, 6 October 2011MartijnVanIerselOntology Term : 'protein degradation pathway' added !
41106view23:22, 1 March 2011MaintBotRemoved redundant pathway information and comments
38876view18:43, 24 September 2010Khanspers
35327view08:29, 12 February 2010Thomasmoved reference from description to bibliography
35326view08:28, 12 February 2010ThomasModified description
34548view20:06, 21 December 2009KhanspersModified description
34547view20:05, 21 December 2009KhanspersLayout
34494view22:26, 16 December 2009KhanspersModified description
32306view13:18, 15 August 2009MaintBotFixed text labels
31890view12:43, 14 August 2009MaintBotFixed group labels
20953view11:30, 14 November 2008MaintBot[[Pathway:Homo sapiens:Matrix Metalloproteinases]] moved to [[Pathway:WP129]]: Moved to stable identifier
14933view15:25, 24 May 2008MartijnVanIerselcreated groups
12963view10:57, 17 May 2008MaintBotSticky edges patch by Sjoerd
8254view13:46, 7 January 2008MaintBot[[Pathway:Human:Matrix Metalloproteinases]] moved to [[Pathway:Homo sapiens:Matrix Metalloproteinases]]: Renaming species
7747view16:15, 18 December 2007MaintBotfixed category names
7428view12:42, 4 November 2007MaintBotAdded categories to GPML
6351view22:18, 22 May 2007Kdahlquistgpml file for [[Human:Matrix_Metalloproteinases]]

External references


View all...
NameTypeDatabase referenceComment
BSGGeneProduct682 (Entrez Gene)
MMP10GeneProduct4319 (Entrez Gene)
MMP11GeneProduct4320 (Entrez Gene)
MMP12GeneProduct4321 (Entrez Gene)
MMP13GeneProduct4322 (Entrez Gene)
MMP1GeneProduct4312 (Entrez Gene)
MMP14GeneProduct4323 (Entrez Gene)
MMP15GeneProduct4324 (Entrez Gene)
MMP16GeneProduct4325 (Entrez Gene)
MMP17GeneProduct4326 (Entrez Gene)
MMP19GeneProduct4327 (Entrez Gene)
MMP20GeneProduct9313 (Entrez Gene)
MMP21GeneProduct118856 (Entrez Gene)
MMP23AGeneProductENSG00000215914 (Ensembl)
MMP23BGeneProduct8510 (Entrez Gene)
MMP24GeneProduct10893 (Entrez Gene)
MMP2GeneProduct4313 (Entrez Gene)
MMP25GeneProduct64386 (Entrez Gene)
MMP26GeneProduct56547 (Entrez Gene)
MMP27GeneProduct64066 (Entrez Gene)
MMP28GeneProduct79148 (Entrez Gene)
MMP3GeneProduct4314 (Entrez Gene)
MMP7GeneProduct4316 (Entrez Gene)
MMP8GeneProduct4317 (Entrez Gene)
MMP9GeneProduct4318 (Entrez Gene)
TCF20GeneProduct6942 (Entrez Gene)
TIMP1GeneProduct7076 (Entrez Gene)
TIMP2GeneProduct7077 (Entrez Gene)
TIMP3GeneProduct7078 (Entrez Gene)
TIMP4GeneProduct7079 (Entrez Gene)
TNFGeneProduct7124 (Entrez Gene)

Annotated Interactions

No annotated interactions

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