Wnt Signaling Pathway and Pluripotency (Rattus norvegicus)

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2PP2ATcf/Lef-1Recruitment to UnknownUbiquitin Conjugating EnzymeProtein Kinase CBIODifferentiationPromotes PluripotencyUbiquitin Taggedbeta-cateninTRTRTR: Transcriptional Regulation+pCytoskeletonNucleusPluripotencybeta-catenin+pIQ1Phosphorylated beta-catenin+pWnt ReceptorsTcf/Lef-1beta-cateninTcf/Lef-1TRFrizzled Ligands26S Proteasome DegradationPromotes DifferentiationStabilized beta-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_predictedGsk3bWnt6Wnt3a


Description

This pathway was adapted from several resources and is designed to provide a theoretical frame-work for examining

Wnt signaling and interacting components in the context of embryonic stem-cell pluripotency and self-renewal. A central organizing theme of this pathway are known drug targets which promote self-renewal or pluripotency (BIO and IQ-1) and implicated upstream regulators of the core pluripotency transcriptional components (e.g. Nanog). It should be noted that it is unclear whether all the depicted components participate in this pathway in human embryonic stem cells. Interactions and object/gene groups for the pathway exist for the majority of components.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP399(r29616) with a 94% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

  1. Miyabayashi T, Teo JL, Yamamoto M, McMillan M, Nguyen C, Kahn M; ''Wnt/beta-catenin/CBP signaling maintains long-term murine embryonic stem cell pluripotency.''; Proc Natl Acad Sci U S A, 2007 PubMed Europe PMC Scholia
  2. ''Kegg version of this pathway''; http://www.genome.jp/kegg/pathway/hsa/hsa04310.html
  3. Sato N, Brivanlou AH; ''Manipulation of self-renewal in human embryonic stem cells through a novel pharmacological GSK-3 inhibitor.''; Methods Mol Biol, 2006 PubMed Europe PMC Scholia
  4. Pereira L, Yi F, Merrill BJ; ''Repression of Nanog gene transcription by Tcf3 limits embryonic stem cell self-renewal.''; Mol Cell Biol, 2006 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
71793view20:33, 17 October 2013MaintBotAutomated update of data sources
69412view19:01, 8 July 2013MaintBotUpdated to 2013 gpml schema
67756view11:59, 26 June 2013DdiglesOntology Term : 'canonical Wnt signaling pathway' added !
58963view18:38, 21 February 2013MaintBotUpdated Ensembl and UniProt data source
47764view05:14, 6 April 2012Khanspersupdated xref
47763view05:13, 6 April 2012Khanspersupdated xref
41733view02:39, 2 March 2011MaintBotRemoved redundant pathway information and comments
34108view19:22, 9 December 2009MaintBotAutomatic update of empty xrefs
32304view13:18, 15 August 2009MaintBotFixed text labels
31888view12:42, 14 August 2009MaintBotFixed group labels
31333view20:23, 13 August 2009MaintBotFixed text labels
30957view00:45, 30 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ApcGeneProduct24205 (Entrez Gene)
Axin1GeneProduct79257 (Entrez Gene)
Axin2GeneProduct29134 (Entrez Gene)
Ccnd1GeneProduct58919 (Entrez Gene)
Ccnd2GeneProduct64033 (Entrez Gene)
Ccnd3GeneProduct25193 (Entrez Gene)
Cd44GeneProduct25406 (Entrez Gene)
CrebbpGeneProduct54244 (Entrez Gene)
Csnk1eGeneProduct58822 (Entrez Gene)
Ctbp1GeneProduct29382 (Entrez Gene)
Ctbp2GeneProduct81717 (Entrez Gene)
Ctnnb1GeneProduct84353 (Entrez Gene)
Ctnnd1GeneProduct311163 (Entrez Gene)
DVL2GeneProduct303251 (Entrez Gene)
Dvl1GeneProduct83721 (Entrez Gene)
Dvl3GeneProduct303811 (Entrez Gene)
Ep300GeneProduct170915 (Entrez Gene)
FRAT1GeneProduct
FZD10GeneProduct
FZD3GeneProduct266715 (Entrez Gene)
FZD7GeneProduct301440 (Entrez Gene)
Fbxw2GeneProduct311881 (Entrez Gene)
Fosl1GeneProduct25445 (Entrez Gene)
Foxd3GeneProductENSRNOG00000009021 (Ensembl)
Fzd1GeneProduct58868 (Entrez Gene)
Fzd2GeneProduct64512 (Entrez Gene)
Fzd4GeneProduct64558 (Entrez Gene)
Fzd5GeneProduct317674 (Entrez Gene)
Fzd6GeneProduct282581 (Entrez Gene)
Fzd8GeneProduct364754 (Entrez Gene)
Fzd9GeneProduct266608 (Entrez Gene)
GrouchoGeneProduct
Gsk3bGeneProduct84027 (Entrez Gene)
JunGeneProduct24516 (Entrez Gene)
LOC679869GeneProductENSRNOG00000013993 (Ensembl)
LdlrGeneProduct300438 (Entrez Gene)
Lef1GeneProduct161452 (Entrez Gene)
Lrp5GeneProduct293649 (Entrez Gene)
Lrp6GeneProduct312781 (Entrez Gene)
Map3k7GeneProduct313121 (Entrez Gene)
Mapk10GeneProduct25272 (Entrez Gene)
Mapk9GeneProduct50658 (Entrez Gene)
Mmp7GeneProduct25335 (Entrez Gene)
MycGeneProduct24577 (Entrez Gene)
NanogGeneProduct414065 (Entrez Gene)
NfyaGeneProductENSRNOG00000012702 (Ensembl)
Nkd1GeneProduct364952 (Entrez Gene)
Nkd2GeneProduct308068 (Entrez Gene)
NlkGeneProduct497961 (Entrez Gene)
PPP2R3BGeneProduct
Pafah1b1GeneProduct83572 (Entrez Gene)
PlauGeneProduct25619 (Entrez Gene)
Pou5f1GeneProduct294562 (Entrez Gene)
PpardGeneProduct25682 (Entrez Gene)
Ppm1jGeneProductENSRNOG00000012481 (Ensembl)
Ppp2caGeneProduct24672 (Entrez Gene)
Ppp2cbGeneProduct24673 (Entrez Gene)
Ppp2r1aGeneProduct117281 (Entrez Gene)
Ppp2r1bGeneProduct315648 (Entrez Gene)
Ppp2r2aGeneProduct117104 (Entrez Gene)
Ppp2r2bGeneProduct60660 (Entrez Gene)
Ppp2r2cGeneProduct117256 (Entrez Gene)
Ppp2r3aGeneProduct363122 (Entrez Gene)
Ppp2r4GeneProduct362102 (Entrez Gene)
Ppp2r5cGeneProduct691318 (Entrez Gene)
Ppp2r5eGeneProduct299147 (Entrez Gene)
PrkcaGeneProduct24680 (Entrez Gene)
PrkcbGeneProduct25023 (Entrez Gene)
PrkccGeneProduct
PrkcdGeneProduct170538 (Entrez Gene)
PrkceGeneProduct29340 (Entrez Gene)
PrkchGeneProduct81749 (Entrez Gene)
PrkciGeneProduct84006 (Entrez Gene)
PrkcqGeneProduct85420 (Entrez Gene)
PrkczGeneProduct25522 (Entrez Gene)
Prkd1GeneProduct85421 (Entrez Gene)
Racgap1GeneProduct315298 (Entrez Gene)
RhoaGeneProduct117273 (Entrez Gene)
Sox2GeneProduct499593 (Entrez Gene)
Tcf3GeneProduct312451 (Entrez Gene)
Tcf7_predictedGeneProductENSRNOG00000005872 (Ensembl)
Tp53GeneProduct24842 (Entrez Gene)
Wnt10aGeneProduct316527 (Entrez Gene)
Wnt10bGeneProduct315294 (Entrez Gene)
Wnt11GeneProduct140584 (Entrez Gene) Non-canonical Wnt signaling enhances differentiation of human circulating progenitor cells to cardiomyogenic cells. PMID: 15701629
Wnt1GeneProduct24881 (Entrez Gene)
Wnt16GeneProduct500047 (Entrez Gene)
Wnt2GeneProduct114487 (Entrez Gene)
Wnt2bGeneProduct116466 (Entrez Gene)
Wnt3GeneProduct24882 (Entrez Gene)
Wnt3aGeneProduct303181 (Entrez Gene)
Wnt4GeneProduct84426 (Entrez Gene)
Wnt5aGeneProduct64566 (Entrez Gene)
Wnt5bGeneProduct282582 (Entrez Gene)
Wnt6GeneProduct316526 (Entrez Gene)
Wnt7aGeneProduct114850 (Entrez Gene)
Wnt7bGeneProduct315196 (Entrez Gene)
Wnt9bGeneProduct303586 (Entrez Gene)
Zbtb33GeneProduct501506 (Entrez Gene)

Annotated Interactions

No annotated interactions
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