EPO Receptor Signaling (Rattus norvegicus)

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EporJak2SrcEpor1, 2PBox-1PPPPPPPPPPY343Y479Box-2Cell membraneDNAY343Y460PPBox-2Box-1PY431EpoShc1Map2k2Map2k1Mapk1Pdk1Mapk3Akt1EpoGrb2Pik3cgStat1Socs1Stat5bCishStat5aStat3Stat3Stat1PtprcPtpruPPPGrb2Raf1Sos1Irs2Jak2Irs1Rasa1Raf1Sos1Rasa1


The erythropoietin receptor is a 66 kDa peptide and is a member of the cytokine receptor family. The receptor is tyrosine phosphorylated upon binding by erythropoietin and associates with and activates the tyrosine kinase, JAK2, which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated erythropoietin receptor appears to have a role in erythroid cell survival. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. Source: Wikipedia This pathway is based on ScienceSlides.


This pathway was inferred from Homo sapiens pathway WP581(r22574) with a 100% conversion rate.

Quality Tags

Ontology Terms



  1. Zhu Y, D'Andrea AD; ''The molecular physiology of erythropoietin and the erythropoietin receptor.''; Curr Opin Hematol, 1994 PubMed Europe PMC
  2. Lacombe C, Mayeux P; ''The molecular biology of erythropoietin.''; Nephrol Dial Transplant, 1999 PubMed Europe PMC


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72051view17:03, 24 October 2013Mkutmonupdated annotation for Pik3cg
69400view18:59, 8 July 2013MaintBotUpdated to 2013 gpml schema
67197view10:19, 26 June 2013Christine ChichesterOntology Term : 'erythropoietin signaling pathway' added !
41719view02:38, 2 March 2011MaintBotRemoved redundant pathway information and comments
35098view13:03, 11 February 2010Thomasadded literature
31884view12:41, 14 August 2009MaintBotFixed group labels
30942view00:41, 30 July 2009MaintBotNew pathway

External references


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NameTypeDatabase referenceComment
Akt1GeneProduct24185 (Entrez Gene)
CishGeneProduct83681 (Entrez Gene)
EpoGeneProduct24335 (Entrez Gene)
EporGeneProduct24336 (Entrez Gene)
Grb2GeneProduct81504 (Entrez Gene)
Irs1GeneProduct25467 (Entrez Gene)
Irs2GeneProduct29376 (Entrez Gene)
Jak2GeneProduct24514 (Entrez Gene)
Map2k1GeneProduct170851 (Entrez Gene)
Map2k2GeneProduct58960 (Entrez Gene)
Mapk1GeneProduct116590 (Entrez Gene)
Mapk3GeneProduct50689 (Entrez Gene)
Pdk1GeneProduct116551 (Entrez Gene)
Pik3cgGeneProductENSRNOG00000009385 (Ensembl)
PtprcGeneProduct24699 (Entrez Gene)
PtpruGeneProduct116680 (Entrez Gene)
Raf1GeneProduct24703 (Entrez Gene)
Rasa1GeneProduct25676 (Entrez Gene)
Shc1GeneProduct85385 (Entrez Gene)
Socs1GeneProduct252971 (Entrez Gene)
Sos1GeneProduct313845 (Entrez Gene)
SrcGeneProduct83805 (Entrez Gene)
Stat1GeneProduct25124 (Entrez Gene)
Stat3GeneProduct25125 (Entrez Gene)
Stat5aGeneProduct24918 (Entrez Gene)
Stat5bGeneProduct25126 (Entrez Gene)

Annotated Interactions

No annotated interactions
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