Selenium Micronutrient Network (Mus musculus)

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INORGANIC IONGENERIC ENZYMEINTRACELULARMETABOLITETransformation TransportGENERIC BINDING PROTEINUnspecified interactions Influence on expression REACTIONNegative effect BindingPositive effect PLASMAFolic acidEndoperoxidaseGpx4Leukotriene C4Leukotriene B4PGD2PGE2TRXR 2glutathione disulfideZincC22:5 (n-6)5-HPETEPGH2MthfrBFads2Leukotriene B4PtgisCatBMethionine sulfoxideAA (n-6)RiboflavinBBBCopperBHomocysteineTPnpoALA (n-3)Leukotriene F4RNSSODEPA (n-3)BPyridoxal 5'-phosphateBLeukotriene D4SelRXdhUric AcidBTa-TocopherolTC22:5 (n-6)BLipoxin B4COX2PGFSNADPHHemeTromboxane A2LA (n-6)DHA (n-3)ALA (n-3)PGE3IronCopperHypoxanthine CysteineTbxas1GlutathioneTLeukotrieneE4Gpx2BKmoSepp1Thromboxane A2BHypoxanthineTRXR 1Alox5Gpx6FMNPGI2d4 desaturasea-tocopherolBSelWPyridoxal 5'-phosphateBGpx1H2OTLA (n-6)F2-IsoprostaneMtrNiacinVitamin B12FADGlutathionePGI2O2BBLipoxin A4Ascorbic acidROSZincNADPLipoic acidPtgdsAscorbic acidTAA (n-6)ManganeseLeukotriene D4SelkFolic acidBPGF2aNADPSeleniumLeukotriene A4BLipoxin A4BPGF2aPGE2Fads1TTN15-HETEPGG2EPA (n-3)15-HETEBCOX1BLeukotriene C4iPF2-alphaTRXR 3BMethioninePGH3TPGG3PGD2ThioredoxinTryptophanLeukotriene E4BNADPHGsrHomocysteineTNIronGpx3BDHA (n-3)XanthineH2O2SeleniumBIEThromboxane B2Methionine BUric acidPtgesCysteineVitamin B12TIE21


The selenium-centred micronutrient biological network. The most relevant biochemical processes related to selenium in the context of metabolism, oxidation and inflammation are represented. Also, the compartmental separation (intracellular vs. plasma) is presented, identifying the selenium centred plasma metabolome. A selenoprotein database exists at:


This pathway was inferred from Homo sapiens pathway WP15(r29615) with a 55% conversion rate.

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Ontology Terms



  1. Denis D, Charleson S, Rackham A, Jones TR, Ford-Hutchinson AW, Lord A, Cirino M, Girard Y, Larue M, Rokach J.; ''Synthesis and biological activities of leukotriene F4 and leukotriene F4 sulfone.''; Prostaglandins., 1982 PubMed Europe PMC Scholia
  2. Guzik TJ, Korbut R, Adamek-Guzik T.; ''Nitric oxide and superoxide in inflammation and immune regulation.''; J Physiol Pharmacol., 2003 PubMed Europe PMC Scholia


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106850view13:33, 17 September 2019MaintBotHMDB identifier normalization
95973view10:21, 11 February 2018EgonwROS is not a protein.
87651view08:54, 25 July 2016LindarieswijkOntology Term : 'selenoamino acid metabolic pathway' added !
85064view11:29, 10 April 2016EgonwReplaced a Wikipedia ID with a ChEBI ID.
82692view18:05, 22 October 2015EgonwFixed a typo.
73551view18:26, 30 January 2014EgonwH2O not H20....
73506view23:16, 29 January 2014KhanspersModified title
73497view23:06, 29 January 2014KhanspersModified title
73495view23:05, 29 January 2014KhanspersModified title
69459view19:10, 8 July 2013EgonwReplaced an outdated HMDB identifier with the 3.5 one.
69087view18:10, 8 July 2013MaintBotUpdated to 2013 gpml schema
69055view18:04, 8 July 2013EgonwReplaced an outdated HMDB identifier with the 3.5 one.
68382view09:37, 4 July 2013EgonwUnmarked more "T"s and "B"s as metabolite.
68381view09:32, 4 July 2013EgonwMore clean up: unmarked things without identifier which do not look like a metabolite (like "T" and "B"), and added an ID for lopoic acid.
68380view09:27, 4 July 2013EgonwMarked a few things with gene identifiers as Protein (rather than GeneProduct, following custom in this pathway).
59028view20:41, 21 February 2013MaintBotUpdated Ensembl and UniProt data source
58514view19:52, 14 February 2013MaintBotModified title
56486view08:50, 8 January 2013EgonwConverted the Type of three DataNodes with an entrez gene ID into "Protein".
43804view22:24, 28 July 2011Samuel SklarSpecify description
43803view18:58, 28 July 2011Samuel SklarSpecify description
43802view18:34, 28 July 2011Samuel SklarPeriodical save, work in progress
43801view18:13, 28 July 2011Samuel SklarPeriodical save, work in progress
43800view18:03, 28 July 2011Samuel SklarPeriodical save, work in progress
41274view00:21, 2 March 2011MaintBotRemoved redundant pathway information and comments
34380view22:46, 9 December 2009MaintBotAutomatic update of empty xrefs
33050view22:24, 7 October 2009MaintBotadded xrefs
31872view12:38, 14 August 2009MaintBotFixed group labels
30905view00:25, 30 July 2009MaintBotNew pathway

External references


View all...
NameTypeDatabase referenceComment
15-HETEMetaboliteHMDB0011134 (HMDB)
5-HPETEMetaboliteHMDB0001193 (HMDB)
AA (n-6)MetaboliteHMDB0001043 (HMDB)
ALA (n-3)MetaboliteHMDB0001388 (HMDB)
Alox5Protein11689 (Entrez Gene)
Ascorbic acidMetaboliteHMDB0000044 (HMDB)
C22:5 (n-6)MetaboliteHMDB0001976 (HMDB)
COX1Protein17708 (Entrez Gene)
COX2Protein17709 (Entrez Gene)
CatProtein12359 (Entrez Gene)
CopperMetaboliteHMDB0000657 (HMDB)
CysteineMetaboliteHMDB0000574 (HMDB)
DHA (n-3)MetaboliteHMDB0002183 (HMDB)
EPA (n-3)MetaboliteHMDB0001999 (HMDB)
F2-IsoprostaneMetaboliteHMDB0004659 (HMDB)
FADMetaboliteHMDB0001248 (HMDB)
FMNProtein342184 (Entrez Gene)
Fads1Protein76267 (Entrez Gene)
Fads2Protein56473 (Entrez Gene)
Folic acidMetaboliteHMDB0000121 (HMDB)
GlutathioneMetaboliteHMDB0000125 (HMDB)
Gpx1Protein14775 (Entrez Gene)
Gpx2Protein14776 (Entrez Gene)
Gpx3Protein14778 (Entrez Gene)
Gpx4Protein625249 (Entrez Gene)
Gpx6Protein75512 (Entrez Gene)
GsrProteinENSMUSG00000031584 (Ensembl)
H2O2MetaboliteHMDB0003125 (HMDB)
H2OMetaboliteHMDB0002111 (HMDB)
HemeMetaboliteHMDB0003178 (HMDB)
HomocysteineMetaboliteHMDB0000742 (HMDB)
Hypoxanthine MetaboliteHMDB0000157 (HMDB)
HypoxanthineMetaboliteHMDB0000157 (HMDB)
IronMetaboliteHMDB0000692 (HMDB)
KmoProtein98256 (Entrez Gene)
LA (n-6)MetaboliteHMDB0000673 (HMDB)
Leukotriene A4MetaboliteHMDB0001337 (HMDB)
Leukotriene B4MetaboliteHMDB0001085 (HMDB)
Leukotriene C4MetaboliteHMDB0001198 (HMDB)
Leukotriene D4MetaboliteHMDB0003080 (HMDB)
Leukotriene E4MetaboliteHMDB0002200 (HMDB)
Leukotriene F4MetaboliteHMDB0006465 (HMDB)
LeukotrieneE4MetaboliteHMDB0002200 (HMDB)
Lipoic acidMetaboliteHMDB0001451 (HMDB)
Lipoxin A4MetaboliteHMDB0004385 (HMDB)
Lipoxin B4MetaboliteHMDB0005082 (HMDB)
ManganeseMetaboliteHMDB0001333 (HMDB)
Methionine MetaboliteHMDB0000696 (HMDB)
Methionine sulfoxideMetaboliteHMDB0002005 (HMDB)
MethionineMetaboliteHMDB0000696 (HMDB)
MthfrProtein17769 (Entrez Gene)
MtrProtein238505 (Entrez Gene)
NADPHMetaboliteHMDB0000221 (HMDB)
NADPMetaboliteHMDB0000217 (HMDB)
NiacinMetaboliteHMDB0001406 (HMDB)
O2MetaboliteHMDB0001377 (HMDB)
PGD2MetaboliteHMDB0001403 (HMDB)
PGE2MetaboliteHMDB0001220 (HMDB)
PGE3MetaboliteHMDB0002664 (HMDB)
PGF2aMetaboliteHMDB0001139 (HMDB)
PGG2MetaboliteHMDB0003235 (HMDB)
PGH2MetaboliteHMDB0001381 (HMDB)
PGI2MetaboliteHMDB0001335 (HMDB)
PnpoProtein103711 (Entrez Gene)
PtgdsProtein19215 (Entrez Gene)
PtgesProtein64292 (Entrez Gene)
PtgisProtein19223 (Entrez Gene)
Pyridoxal 5'-phosphateMetaboliteHMDB0001491 (HMDB)
ROSMetaboliteCHEBI:26523 (ChEBI)
RiboflavinMetaboliteHMDB0000244 (HMDB)
SelRProtein51734 (Entrez Gene)
SelWProtein6415 (Entrez Gene)
SeleniumMetaboliteHMDB0001349 (HMDB)
SelkProtein80795 (Entrez Gene)
Sepp1Protein20363 (Entrez Gene)
TGeneProduct0 (Entrez Gene)
TRXR 1Protein7296 (Entrez Gene)
TRXR 2Protein10587 (Entrez Gene)
TRXR 3Protein114112 (Entrez Gene)
Tbxas1Protein21391 (Entrez Gene)
ThioredoxinProtein7295 (Entrez Gene)
Thromboxane A2MetaboliteHMDB0001452 (HMDB)
Thromboxane B2MetaboliteHMDB0003252 (HMDB)
Tromboxane A2MetaboliteHMDB0001452 (HMDB)
TryptophanMetaboliteHMDB0000929 (HMDB)
Uric AcidMetaboliteHMDB0000289 (HMDB)
Uric acidMetaboliteHMDB0000289 (HMDB)
Vitamin B12MetaboliteHMDB0002174 (HMDB)
XanthineMetaboliteHMDB0000292 (HMDB)
XdhProtein22436 (Entrez Gene)
ZincMetaboliteHMDB0001303 (HMDB)
a-TocopherolMetaboliteHMDB0001893 (HMDB)
a-tocopherolMetaboliteHMDB0001893 (HMDB)
d4 desaturaseProtein
glutathione disulfideMetaboliteHMDB0000656 (HMDB)
iPF2-alphaMetaboliteHMDB0004659 (HMDB)

Annotated Interactions

No annotated interactions
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