Endochondral Ossification (Mus musculus)

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1, 2Chondrocyte (pre)hypertrophyHypertrophyRemoval of extracellular matrixand invasion by bone cellsCathepsinsand CalpainsBMPsChondrocyte deathFull differentiationVascular invastionOsteoblasticdifferentiationChondrocyte proliferation?CartilageMineralisationRemoval of cartilage matrixDyingBoneintegrinsGsProliferationWNT signalingcanonical / non-canonicalKif3aBmpr1aSox6CtslIhhCalm1OxygenSpp1Ptch1Runx3Serpinh1Fgf18Fgfr1Ptch1Tgfb2Igf2Cdkn1cAlplBmp6PlatMgpPthlhDdr2Fgf2cAMPAcanFgfr3Tgfb1Timp3TNAPRunx2Thyroid hormoneNkx3-2Cst10GhrAdamts1Igf1rAkt1Bmp7ThraTgfb1Pth1rSox5Enpp1Hmgcs1Slc38a2Mmp13Runx2Chst11Col2a1Sox9Mmp9Mef2cCol10a1Adamts4PthVegfaScinCab39TriiodothyronineThyroid hormoneThraAdamts5Hdac4FrzbGli3PrkacaIgf1Growth hormoneIft88Runx2PlauStat1Stat5b


Description

No description

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP474(r29737) with a 94% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

  1. Belluoccio D, Bernardo BC, Rowley L, Bateman JF; ''A microarray approach for comparative expression profiling of the discrete maturation zones of mouse growth plate cartilage.''; Biochim Biophys Acta, 2008 PubMed Europe PMC
  2. Mackie EJ, Ahmed YA, Tatarczuch L, Chen KS, Mirams M; ''Endochondral ossification: how cartilage is converted into bone in the developing skeleton.''; Int J Biochem Cell Biol, 2008 PubMed Europe PMC

History

View all...
CompareRevisionActionTimeUserComment
107195view14:28, 17 September 2019MaintBotChEBI identifier normalization
106849view13:32, 17 September 2019MaintBotHMDB identifier normalization
87973view13:17, 25 July 2016SusanOntology Term : 'regulatory pathway' added !
72216view12:55, 27 October 2013EgonwFixed the ChEBI database name.
72176view22:19, 25 October 2013AlexanderPicoAdded missing metabolite identifiers.
69106view18:12, 8 July 2013MaintBotUpdated to 2013 gpml schema
41292view00:22, 2 March 2011MaintBotRemoved redundant pathway information and comments
32869view21:22, 16 September 2009MaintBotAdded xrefs
32298view13:15, 15 August 2009MaintBotFixed text labels
31870view12:38, 14 August 2009MaintBotFixed group labels
31327view20:20, 13 August 2009MaintBotFixed text labels
30897view00:23, 30 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AcanGeneProduct11595 (Entrez Gene)
Adamts1GeneProduct11504 (Entrez Gene)
Adamts4GeneProduct240913 (Entrez Gene)
Adamts5GeneProduct23794 (Entrez Gene)
Akt1GeneProduct11651 (Entrez Gene)
AlplGeneProduct11647 (Entrez Gene)
Bmp6GeneProduct12161 (Entrez Gene)
Bmp7GeneProduct12162 (Entrez Gene)
Bmpr1aGeneProduct12166 (Entrez Gene)
Cab39GeneProduct12283 (Entrez Gene)
Calm1GeneProduct12313 (Entrez Gene)
Cdkn1cGeneProduct12577 (Entrez Gene)
Chst11GeneProduct58250 (Entrez Gene)
Col10a1GeneProduct12813 (Entrez Gene)
Col2a1GeneProduct12824 (Entrez Gene)
Cst10GeneProduct58214 (Entrez Gene)
  • Taken as human homologue of mouse Cst10
  • PMID: 13679380
CtslGeneProduct13039 (Entrez Gene) Taken as homologue to mouse Cathepsin L (Ctsl)
Ddr2GeneProduct18214 (Entrez Gene)
Enpp1GeneProduct18605 (Entrez Gene)
Fgf18GeneProduct14172 (Entrez Gene)
Fgf2GeneProduct14173 (Entrez Gene)
Fgfr1GeneProduct14182 (Entrez Gene)
Fgfr3GeneProduct14184 (Entrez Gene)
FrzbGeneProduct20378 (Entrez Gene)
GhrGeneProduct14600 (Entrez Gene)
Gli3GeneProduct14634 (Entrez Gene)
Growth hormoneGeneProduct
Hdac4GeneProduct208727 (Entrez Gene)
Hmgcs1GeneProduct208715 (Entrez Gene)
Ift88GeneProduct21821 (Entrez Gene)
Igf1GeneProduct16000 (Entrez Gene)
Igf1rGeneProduct16001 (Entrez Gene)
Igf2GeneProduct16002 (Entrez Gene)
IhhGeneProduct16147 (Entrez Gene)
Kif3aGeneProduct16568 (Entrez Gene)
Mef2cGeneProduct17260 (Entrez Gene)
MgpGeneProduct17313 (Entrez Gene)
Mmp13GeneProduct17386 (Entrez Gene)
Mmp9GeneProduct17395 (Entrez Gene)
Nkx3-2GeneProduct12020 (Entrez Gene)
OxygenMetaboliteHMDB01377 (HMDB)
PlatGeneProduct18791 (Entrez Gene)
PlauGeneProduct18792 (Entrez Gene)
PrkacaGeneProduct18747 (Entrez Gene)
Ptch1GeneProduct19206 (Entrez Gene)
PthGeneProduct19226 (Entrez Gene)
Pth1rGeneProduct19228 (Entrez Gene)
PthlhGeneProduct19227 (Entrez Gene)
Runx2GeneProduct12393 (Entrez Gene)
Runx3GeneProduct12399 (Entrez Gene)
ScinGeneProduct20259 (Entrez Gene) PMID: 17097081
Serpinh1GeneProduct12406 (Entrez Gene)
Slc38a2GeneProduct67760 (Entrez Gene)
Sox5GeneProduct20678 (Entrez Gene)
Sox6GeneProduct20679 (Entrez Gene)
Sox9GeneProduct20682 (Entrez Gene)
Spp1GeneProduct20750 (Entrez Gene)
Stat1GeneProduct20846 (Entrez Gene)
Stat5bGeneProduct20851 (Entrez Gene)
TNAPGeneProduct
Tgfb1GeneProduct21803 (Entrez Gene)
Tgfb2GeneProduct21808 (Entrez Gene)
ThraGeneProduct21833 (Entrez Gene)
Thyroid hormoneMetabolite60311 (ChEBI)
Thyroid hormoneMetaboliteT4
Timp3GeneProduct21859 (Entrez Gene)
TriiodothyronineMetabolite24864 (ChEBI)
VegfaGeneProduct22339 (Entrez Gene)
cAMPMetaboliteHMDB00058 (HMDB)

Annotated Interactions

No annotated interactions
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