Endochondral ossification (Mus musculus)

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1, 2Removal of extracellular matrixand invasion by bone cells?BMPsRemoval of cartilage matrixVascular invastionCartilageChondrocyte (pre)hypertrophyFull differentiationintegrinsProliferationDyingWNT signalingcanonical / non-canonicalOsteoblasticdifferentiationChondrocyte proliferationHypertrophyBoneChondrocyte deathGsCathepsinsand CalpainsMineralisationSpp1Ptch1Mmp9GhrTriiodothyroninePlatThraSox6Mef2cSerpinh1Nkx3-2Chst11Cst10Ddr2PrkacaTgfb1Ift88Tgfb1ScinPlauCol10a1Cab39Gli3Tgfb2PthGrowth hormoneRunx2Enpp1FrzbFgfr3Pth1rSox5Cdkn1cMmp13Igf1Stat1Bmp6OxygenRunx2Fgfr1cAMPAdamts5VegfaAcanAdamts4Hdac4Thyroid hormonePthlhAlplHmgcs1Akt1Fgf18Runx2Sox9Fgf2Adamts1Thyroid hormoneStat5bIgf1rKif3aPtch1Igf2ThraBmp7TNAPCol2a1Runx3IhhBmpr1aTimp3Calm1MgpCtslSlc38a2


Description

No description

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP474(r29737) with a 94% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

  1. Belluoccio D, Bernardo BC, Rowley L, Bateman JF; ''A microarray approach for comparative expression profiling of the discrete maturation zones of mouse growth plate cartilage.''; Biochim Biophys Acta, 2008 PubMed Europe PMC Scholia
  2. Mackie EJ, Ahmed YA, Tatarczuch L, Chen KS, Mirams M; ''Endochondral ossification: how cartilage is converted into bone in the developing skeleton.''; Int J Biochem Cell Biol, 2008 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
117880view10:21, 23 May 2021EweitzModified title
114026view15:29, 17 December 2020Fehrhartconnected lines
107195view14:28, 17 September 2019MaintBotChEBI identifier normalization
106849view13:32, 17 September 2019MaintBotHMDB identifier normalization
87973view13:17, 25 July 2016SusanOntology Term : 'regulatory pathway' added !
72216view12:55, 27 October 2013EgonwFixed the ChEBI database name.
72176view22:19, 25 October 2013AlexanderPicoAdded missing metabolite identifiers.
69106view18:12, 8 July 2013MaintBotUpdated to 2013 gpml schema
41292view00:22, 2 March 2011MaintBotRemoved redundant pathway information and comments
32869view21:22, 16 September 2009MaintBotAdded xrefs
32298view13:15, 15 August 2009MaintBotFixed text labels
31870view12:38, 14 August 2009MaintBotFixed group labels
31327view20:20, 13 August 2009MaintBotFixed text labels
30897view00:23, 30 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AcanGeneProduct11595 (Entrez Gene)
Adamts1GeneProduct11504 (Entrez Gene)
Adamts4GeneProduct240913 (Entrez Gene)
Adamts5GeneProduct23794 (Entrez Gene)
Akt1GeneProduct11651 (Entrez Gene)
AlplGeneProduct11647 (Entrez Gene)
Bmp6GeneProduct12161 (Entrez Gene)
Bmp7GeneProduct12162 (Entrez Gene)
Bmpr1aGeneProduct12166 (Entrez Gene)
Cab39GeneProduct12283 (Entrez Gene)
Calm1GeneProduct12313 (Entrez Gene)
Cdkn1cGeneProduct12577 (Entrez Gene)
Chst11GeneProduct58250 (Entrez Gene)
Col10a1GeneProduct12813 (Entrez Gene)
Col2a1GeneProduct12824 (Entrez Gene)
Cst10GeneProduct58214 (Entrez Gene)
  • Taken as human homologue of mouse Cst10
  • PMID: 13679380
CtslGeneProduct13039 (Entrez Gene) Taken as homologue to mouse Cathepsin L (Ctsl)
Ddr2GeneProduct18214 (Entrez Gene)
Enpp1GeneProduct18605 (Entrez Gene)
Fgf18GeneProduct14172 (Entrez Gene)
Fgf2GeneProduct14173 (Entrez Gene)
Fgfr1GeneProduct14182 (Entrez Gene)
Fgfr3GeneProduct14184 (Entrez Gene)
FrzbGeneProduct20378 (Entrez Gene)
GhrGeneProduct14600 (Entrez Gene)
Gli3GeneProduct14634 (Entrez Gene)
Growth hormoneGeneProduct
Hdac4GeneProduct208727 (Entrez Gene)
Hmgcs1GeneProduct208715 (Entrez Gene)
Ift88GeneProduct21821 (Entrez Gene)
Igf1GeneProduct16000 (Entrez Gene)
Igf1rGeneProduct16001 (Entrez Gene)
Igf2GeneProduct16002 (Entrez Gene)
IhhGeneProduct16147 (Entrez Gene)
Kif3aGeneProduct16568 (Entrez Gene)
Mef2cGeneProduct17260 (Entrez Gene)
MgpGeneProduct17313 (Entrez Gene)
Mmp13GeneProduct17386 (Entrez Gene)
Mmp9GeneProduct17395 (Entrez Gene)
Nkx3-2GeneProduct12020 (Entrez Gene)
OxygenMetaboliteHMDB0001377 (HMDB)
PlatGeneProduct18791 (Entrez Gene)
PlauGeneProduct18792 (Entrez Gene)
PrkacaGeneProduct18747 (Entrez Gene)
Ptch1GeneProduct19206 (Entrez Gene)
PthGeneProduct19226 (Entrez Gene)
Pth1rGeneProduct19228 (Entrez Gene)
PthlhGeneProduct19227 (Entrez Gene)
Runx2GeneProduct12393 (Entrez Gene)
Runx3GeneProduct12399 (Entrez Gene)
ScinGeneProduct20259 (Entrez Gene) PMID: 17097081
Serpinh1GeneProduct12406 (Entrez Gene)
Slc38a2GeneProduct67760 (Entrez Gene)
Sox5GeneProduct20678 (Entrez Gene)
Sox6GeneProduct20679 (Entrez Gene)
Sox9GeneProduct20682 (Entrez Gene)
Spp1GeneProduct20750 (Entrez Gene)
Stat1GeneProduct20846 (Entrez Gene)
Stat5bGeneProduct20851 (Entrez Gene)
TNAPGeneProduct
Tgfb1GeneProduct21803 (Entrez Gene)
Tgfb2GeneProduct21808 (Entrez Gene)
ThraGeneProduct21833 (Entrez Gene)
Thyroid hormoneMetaboliteCHEBI:60311 (ChEBI)
Thyroid hormoneMetaboliteT4
Timp3GeneProduct21859 (Entrez Gene)
TriiodothyronineMetaboliteCHEBI:24864 (ChEBI)
VegfaGeneProduct22339 (Entrez Gene)
cAMPMetaboliteHMDB0000058 (HMDB)

Annotated Interactions

No annotated interactions
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