Nod-like receptor (NLR) signaling pathway (Mus musculus)

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1-5, 75CARDIκBαCARDdegradationASCp20K63-linked UbPYDtranscriptionInflammasome pathwayPYDNALP3p10RIP2KDTAB2CARDNod2NACHTPYDCARDPYDp10p20Nod1IL-1� and IL-18NACHTNACHTNACHTNACHTPYDCaspase-1TAB1CARDRelAMAPKIkbkbMap3k7IkbkgCd40TriDAPChukErbb2ipCARDDAMPSCARDCARDMapk8Ephb2MDP


Mammalian cells have evolved a set of specialized pattern recognition-molecules (PRMs) to detect conserved molecular motifs present on pathogens known as pathogen-associated-molecular-patterns (PAMPs). NLR proteins (alternatively named NBD-LRR or CATERPILLER) represent one subclass of PRMs that have recently attracted much attention. Their cytoplasmic location differs from the classical PRMs which are mostly membrane spanning receptors (such as the Toll-like-receptors (TLRs) or lectins) and accordingly NLRs were proposed to be activated mainly by intracellular bacterial pathogens.


This pathway was inferred from Homo sapiens pathway WP288(r28883) with a 57% conversion rate.

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  1. Carneiro LA, Magalhaes JG, Tattoli I, Philpott DJ, Travassos LH; ''Nod-like proteins in inflammation and disease.''; J Pathol, 2008 PubMed Europe PMC Scholia
  2. Meylan E, Tschopp J, Karin M; ''Intracellular pattern recognition receptors in the host response.''; Nature, 2006 PubMed Europe PMC Scholia
  3. Fritz JH, Ferrero RL, Philpott DJ, Girardin SE; ''Nod-like proteins in immunity, inflammation and disease.''; Nat Immunol, 2006 PubMed Europe PMC Scholia
  4. Shaw MH, Reimer T, Kim YG, Nu�ez G; ''NOD-like receptors (NLRs): bona fide intracellular microbial sensors.''; Curr Opin Immunol, 2008 PubMed Europe PMC Scholia
  5. Mariathasan S, Monack DM; ''Inflammasome adaptors and sensors: intracellular regulators of infection and inflammation.''; Nat Rev Immunol, 2007 PubMed Europe PMC Scholia
  6. kufer t;
  7. Kufer TA; ''Signal transduction pathways used by NLR-type innate immune receptors.''; Mol Biosyst, 2008 PubMed Europe PMC Scholia


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117031view14:02, 16 May 2021EweitzModified title
71759view20:25, 17 October 2013MaintBotremoved data source from nodes without identifier
70191view01:58, 13 July 2013AlexanderPicoModified title
69949view20:36, 11 July 2013MaintBotModified description
69920view19:46, 11 July 2013MaintBotupdating to 2013 schema
67509view11:18, 26 June 2013DdiglesOntology Term : 'NOD-like receptor signaling pathway' added !
41241view00:19, 2 March 2011MaintBotRemoved redundant pathway information and comments
34370view22:41, 9 December 2009MaintBotAutomatic update of empty xrefs
32295view13:13, 15 August 2009MaintBotFixed text labels
31861view12:34, 14 August 2009MaintBotFixed group labels
31323view20:18, 13 August 2009MaintBotFixed text labels
30866view00:12, 30 July 2009MaintBotNew pathway

External references


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NameTypeDatabase referenceComment
Cd40GeneProduct21939 (Entrez Gene)
ChukGeneProduct12675 (Entrez Gene)
Ephb2GeneProduct13844 (Entrez Gene)
Erbb2ipGeneProduct59079 (Entrez Gene)
IkbkbGeneProduct16150 (Entrez Gene)
IkbkgGeneProduct16151 (Entrez Gene)
Map3k7GeneProduct26409 (Entrez Gene)
Mapk8GeneProduct26419 (Entrez Gene)
RelAGeneProduct19697 (Entrez Gene)

Annotated Interactions

No annotated interactions
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