Type II interferon signaling (IFNG) (Mus musculus)

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1AP[P]O&ORORCytoplasmTP[P] [P]&ExtracellularSpacePTOPBBPlasmaMembraneB[P]TORBP[P]OR-PNucleusBORIfnb1IFNAIsgf3Irf9Irf8Ifngr2Socs1Stat1Stat2Jak2Isg15Jak1Stat1Stat2Irf1Stat1Jak1Tap1Stat1Stat1Ifngr2Sfpi1Irf9Jak2Stat2GBP1Ifit2Jak1Irf2Isgf3Stat1Stat1Ifngr1Stat1Ptpn11Stat1Ifngr2Irf8HIST2H4HLA-BIfngIcam1Irf9Jak2Irf4Ifngr1IfngIfngStat1Reg1Ifngr1Stat1Nos2IfngStat1Socs3Jak2Stat2IfngCiitaPrkcdIfngr1Psmb9G1P3Cxcl10Cxcl9Stat1Irf9Stat1Stat1Stat1Eif2ak2Ifngr2Stat1OAS1Irf9CybbIl1bJak1


Adapted from Raza et al. (2008). This pathway is initiated by IFNG binding to its receptor and a subsequent phosphorylation cascade involving a number of the JAK and STAT family of proteins. Several transcriptionally active complexes are formed (STAT1 homodimer, ISGF3 complex, STAT1:STAT1:IRF9 complex) and the pathway culminates with the transcriptional activation of target genes. [1]


This pathway was inferred from Homo sapiens pathway WP619(r28124) with a 92% conversion rate.

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Ontology Terms



  1. Raza S, Robertson KA, Lacaze PA, Page D, Enright AJ, Ghazal P, Freeman TC; ''A logic-based diagram of signalling pathways central to macrophage activation.''; BMC Syst Biol, 2008 PubMed Europe PMC Scholia


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71753view20:20, 17 October 2013MaintBotAutomated update of data sources
71170view11:06, 11 October 2013Mkutmonfix unconnected lines
69194view18:23, 8 July 2013MaintBotUpdated to 2013 gpml schema
67731view11:56, 26 June 2013DdiglesOntology Term : 'Type II interferon signaling pathway' added !
48389view22:06, 23 May 2012Khanspersupdated xrefs
41385view00:29, 2 March 2011MaintBotRemoved redundant pathway information and comments
39412view22:28, 23 November 2010AlexanderPicoOntology Term : 'macrophage' added !
39411view22:26, 23 November 2010AlexanderPicoOntology Term : 'CL:0000000' removed !
39403view05:38, 23 November 2010ChaodcOntology Term : 'Cell Type' added !
34425view23:20, 9 December 2009MaintBotAutomatic update of empty xrefs
32294view13:13, 15 August 2009MaintBotFixed text labels
31858view12:33, 14 August 2009MaintBotFixed group labels
31322view20:18, 13 August 2009MaintBotFixed text labels
30855view00:08, 30 July 2009MaintBotNew pathway

External references


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NameTypeDatabase referenceComment
CiitaGeneProduct12265 (Entrez Gene)
Cxcl10GeneProduct15945 (Entrez Gene)
Cxcl9GeneProduct17329 (Entrez Gene)
CybbGeneProduct13058 (Entrez Gene)
Eif2ak2GeneProduct19106 (Entrez Gene)
GBP1GeneProduct14468 (Entrez Gene)
HIST2H4GeneProduct97122 (Entrez Gene)
IFNAGeneProduct111654 (Entrez Gene)
Icam1GeneProduct15894 (Entrez Gene)
Ifit2GeneProduct15958 (Entrez Gene)
Ifnb1GeneProduct15977 (Entrez Gene)
IfngGeneProduct15978 (Entrez Gene)
Ifngr1GeneProduct15979 (Entrez Gene)
Ifngr2GeneProduct15980 (Entrez Gene)
Il1bGeneProduct16176 (Entrez Gene)
Irf1GeneProduct16362 (Entrez Gene)
Irf2GeneProduct16363 (Entrez Gene)
Irf4GeneProduct16364 (Entrez Gene)
Irf8GeneProduct15900 (Entrez Gene)
Irf9GeneProduct16391 (Entrez Gene)
Isg15GeneProduct100038882 (Entrez Gene)
Jak1GeneProduct16451 (Entrez Gene)
Jak2GeneProduct16452 (Entrez Gene)
Nos2GeneProduct18126 (Entrez Gene)
PrkcdGeneProduct18753 (Entrez Gene)
Psmb9GeneProduct16912 (Entrez Gene)
Ptpn11GeneProduct19247 (Entrez Gene)
Reg1GeneProduct19692 (Entrez Gene)
Sfpi1GeneProduct20375 (Entrez Gene)
Socs1GeneProduct12703 (Entrez Gene)
Socs3GeneProduct12702 (Entrez Gene)
Stat1GeneProduct20846 (Entrez Gene)
Stat2GeneProduct20847 (Entrez Gene)
Tap1GeneProduct21354 (Entrez Gene)

Annotated Interactions

No annotated interactions
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