Hypothetical Network for Drug Addiction (Mus musculus)

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1Long-term potentiationNMDARGnRH Signal pathwayAMPARStrong depolarizationRegulation of actin cytoskeletonmGluRGonadotropins gene expression & secretionMAPK signaling pathwayGap junctionNeuroactive ligand-receptorinteractionRegulation of gap junctionLocal TranslationKrit1D-GlutamatePrkceNischMap2k2connexinGrin2dAdcy1GiGrm5Drd1aGria2Zhx2PrkacaPpa1Gria1GsCamk2bAdcy1Grin2cPrkacaDrd2Gria4Camk4Acta1Creb1Grm1Ca++Terf2ipGrin2bMapk1Grin2aMapk3connexinCyclic AMPGria3Grin1Adcy8Map2k1Drd4


Adapted from figure 2 in Li et al..


This pathway was inferred from Homo sapiens pathway WP666(r29740) with a 89% conversion rate.

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Ontology Terms



  1. Li CY, Mao X, Wei L; ''Genes and (common) pathways underlying drug addiction.''; PLoS Comput Biol, 2008 PubMed Europe PMC Scholia


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107193view14:28, 17 September 2019MaintBotChEBI identifier normalization
102279view08:37, 17 December 2018EgonwReplaced the ChEBI idea of Ca(0) with that of Ca2++
69102view18:12, 8 July 2013MaintBotUpdated to 2013 gpml schema
67352view10:41, 26 June 2013Christine ChichesterOntology Term : 'substance dependence disease pathway' added !
48795view13:04, 19 June 2012MartijnVanIerseltiny tweak to regenerate SVG
41287view00:22, 2 March 2011MaintBotRemoved redundant pathway information and comments
34386view22:49, 9 December 2009MaintBotAutomatic update of empty xrefs
32292view13:12, 15 August 2009MaintBotFixed text labels
31851view12:32, 14 August 2009MaintBotFixed group labels
31320view20:17, 13 August 2009MaintBotFixed text labels
30831view00:01, 30 July 2009MaintBotNew pathway

External references


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NameTypeDatabase referenceComment
Acta1GeneProduct11459 (Entrez Gene)
Adcy1GeneProduct432530 (Entrez Gene)
Adcy8GeneProduct11514 (Entrez Gene)
Ca++Metabolite29320 (ChEBI)
Camk2bGeneProduct12323 (Entrez Gene)
Camk4GeneProduct12326 (Entrez Gene)
Creb1GeneProduct12912 (Entrez Gene)
Cyclic AMPMetabolite17489 (ChEBI)
D-GlutamateMetabolite15966 (ChEBI)
Drd1aGeneProduct13488 (Entrez Gene)
Drd2GeneProduct13489 (Entrez Gene)
Drd4GeneProduct13491 (Entrez Gene)
Gria1GeneProduct14799 (Entrez Gene)
Gria2GeneProduct14800 (Entrez Gene)
Gria3GeneProduct53623 (Entrez Gene)
Gria4GeneProduct14802 (Entrez Gene)
Grin1GeneProduct14810 (Entrez Gene)
Grin2aGeneProduct14811 (Entrez Gene)
Grin2bGeneProduct14812 (Entrez Gene)
Grin2cGeneProduct14813 (Entrez Gene)
Grin2dGeneProduct14814 (Entrez Gene)
Grm1GeneProduct14816 (Entrez Gene)
Grm5GeneProduct108071 (Entrez Gene)
GsGeneProduct109550 (Entrez Gene)
Krit1GeneProduct79264 (Entrez Gene)
Map2k1GeneProduct26395 (Entrez Gene)
Map2k2GeneProduct26396 (Entrez Gene)
Mapk1GeneProduct26413 (Entrez Gene)
Mapk3GeneProduct26417 (Entrez Gene)
NischGeneProduct64652 (Entrez Gene)
Ppa1GeneProduct67895 (Entrez Gene)
PrkacaGeneProduct18747 (Entrez Gene)
PrkceGeneProduct18754 (Entrez Gene)
Terf2ipGeneProduct57321 (Entrez Gene)
Zhx2GeneProduct387609 (Entrez Gene)

Annotated Interactions

No annotated interactions
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