Hypothetical Network for Drug Addiction (Mus musculus)

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1MAPK signaling pathwayAMPARRegulation of actin cytoskeletonStrong depolarizationRegulation of gap junctionGnRH Signal pathwayNeuroactive ligand-receptorinteractionLong-term potentiationmGluRLocal TranslationGonadotropins gene expression & secretionNMDARGap junctionDrd2Grm1Grin2bAdcy1Gria3PrkacaPrkceCamk4Gria2Grm5Drd1aDrd4Mapk1Grin2aNischZhx2D-GlutamateCyclic AMPMap2k1Adcy8Gria4GsTerf2ipGiGrin1PrkacaGrin2cconnexinMapk3Grin2dCamk2bKrit1Creb1connexinActa1Gria1Adcy1Ppa1Map2k2Ca++


Adapted from figure 2 in Li et al..


This pathway was inferred from Homo sapiens pathway WP666(r29740) with a 89% conversion rate.

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Ontology Terms



  1. Li CY, Mao X, Wei L; ''Genes and (common) pathways underlying drug addiction.''; PLoS Comput Biol, 2008 PubMed Europe PMC Scholia


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107193view14:28, 17 September 2019MaintBotChEBI identifier normalization
102279view08:37, 17 December 2018EgonwReplaced the ChEBI idea of Ca(0) with that of Ca2++
69102view18:12, 8 July 2013MaintBotUpdated to 2013 gpml schema
67352view10:41, 26 June 2013Christine ChichesterOntology Term : 'substance dependence disease pathway' added !
48795view13:04, 19 June 2012MartijnVanIerseltiny tweak to regenerate SVG
41287view00:22, 2 March 2011MaintBotRemoved redundant pathway information and comments
34386view22:49, 9 December 2009MaintBotAutomatic update of empty xrefs
32292view13:12, 15 August 2009MaintBotFixed text labels
31851view12:32, 14 August 2009MaintBotFixed group labels
31320view20:17, 13 August 2009MaintBotFixed text labels
30831view00:01, 30 July 2009MaintBotNew pathway

External references


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NameTypeDatabase referenceComment
Acta1GeneProduct11459 (Entrez Gene)
Adcy1GeneProduct432530 (Entrez Gene)
Adcy8GeneProduct11514 (Entrez Gene)
Ca++MetaboliteCHEBI:29108 (ChEBI)
Camk2bGeneProduct12323 (Entrez Gene)
Camk4GeneProduct12326 (Entrez Gene)
Creb1GeneProduct12912 (Entrez Gene)
Cyclic AMPMetaboliteCHEBI:17489 (ChEBI)
D-GlutamateMetaboliteCHEBI:15966 (ChEBI)
Drd1aGeneProduct13488 (Entrez Gene)
Drd2GeneProduct13489 (Entrez Gene)
Drd4GeneProduct13491 (Entrez Gene)
Gria1GeneProduct14799 (Entrez Gene)
Gria2GeneProduct14800 (Entrez Gene)
Gria3GeneProduct53623 (Entrez Gene)
Gria4GeneProduct14802 (Entrez Gene)
Grin1GeneProduct14810 (Entrez Gene)
Grin2aGeneProduct14811 (Entrez Gene)
Grin2bGeneProduct14812 (Entrez Gene)
Grin2cGeneProduct14813 (Entrez Gene)
Grin2dGeneProduct14814 (Entrez Gene)
Grm1GeneProduct14816 (Entrez Gene)
Grm5GeneProduct108071 (Entrez Gene)
GsGeneProduct109550 (Entrez Gene)
Krit1GeneProduct79264 (Entrez Gene)
Map2k1GeneProduct26395 (Entrez Gene)
Map2k2GeneProduct26396 (Entrez Gene)
Mapk1GeneProduct26413 (Entrez Gene)
Mapk3GeneProduct26417 (Entrez Gene)
NischGeneProduct64652 (Entrez Gene)
Ppa1GeneProduct67895 (Entrez Gene)
PrkacaGeneProduct18747 (Entrez Gene)
PrkceGeneProduct18754 (Entrez Gene)
Terf2ipGeneProduct57321 (Entrez Gene)
Zhx2GeneProduct387609 (Entrez Gene)

Annotated Interactions

No annotated interactions
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