Keap1-Nrf2 (Mus musculus)

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1CCAAT/XRET-PPhase II enzymesARES-PT-PNucleusS-PKeap1Caffeic acid phenethyl esterCebpb6-HITCSulforaphaneAimp2Mapk8CurcuminNqo1GclcNfe2l2Nfe2l2Hmox1PrkcaGclmNfe2l2Ephb2Gsta2CebpbPik3caMafKeap1



This pathway was inferred from Homo sapiens pathway WP3(r29720) with a 94% conversion rate.

Quality Tags

Ontology Terms



  1. Surh YJ; ''Cancer chemoprevention with dietary phytochemicals.''; Nat Rev Cancer, 2003 PubMed Europe PMC Scholia


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106837view13:31, 17 September 2019MaintBotHMDB identifier normalization
89978view18:45, 6 October 2016Mkutmonfix unconnected lines
71125view11:44, 7 October 2013SusanConnected lines
69176view18:21, 8 July 2013MaintBotUpdated to 2013 gpml schema
67419view10:59, 26 June 2013DdiglesOntology Term : 'nuclear factor, erythroid derived 2, like 2 signaling pathway' added !
48229view05:32, 17 May 2012MaintBotAutomatic update of PubChem xrefs
41366view00:28, 2 March 2011MaintBotRemoved redundant pathway information and comments
32699view18:17, 1 September 2009MaintBotadded xref
31850view12:32, 14 August 2009MaintBotFixed group labels
30829view00:01, 30 July 2009MaintBotNew pathway

External references


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NameTypeDatabase referenceComment
6-HITCMetaboliteFull name: 6-(Methylsulfinyl)hexylisothiocyanate, or Japanese horseradish wasabi
Aimp2GeneProduct231872 (Entrez Gene)
Caffeic acid phenethyl esterMetabolite
CebpbGeneProduct12608 (Entrez Gene)
CurcuminMetaboliteHMDB0002269 (HMDB)
Ephb2GeneProduct13844 (Entrez Gene)
GclcGeneProduct14629 (Entrez Gene)
GclmGeneProduct14630 (Entrez Gene)
Gsta2GeneProduct14858 (Entrez Gene)
Hmox1GeneProduct15368 (Entrez Gene)
Keap1GeneProduct50868 (Entrez Gene)
MafGeneProduct17132 (Entrez Gene)
Mapk8GeneProduct26419 (Entrez Gene)
Nfe2l2GeneProduct18024 (Entrez Gene)
Nqo1GeneProduct18104 (Entrez Gene)
Pik3caGeneProduct18706 (Entrez Gene)
PrkcaGeneProduct18750 (Entrez Gene)
SulforaphaneMetaboliteHMDB0005792 (HMDB)

Annotated Interactions

No annotated interactions
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