Estrogen signaling (Mus musculus)

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Transcription Initiation Factors (TIFs)TIFsTFIIE+pActivationanti apoptosis+pRNA polymerase IITFIIATFIIBERE+pHistone Deacetylases (HDACs)TFIIDIKKsTFIIHTranslocationRNA Pol IIGene expression(anti apoptotic)MitochondrionHDACsNucleusInhibitionTATA Box bindingproteinGene expressionMAPKsTFIIFCrebbpPolr2hGtf2e1JunGtf2a2Hdac5Akt1Taf7Mnat1Nfkb1Hdac8SrcSin3aErcc2Polr2jHdac7Polr2gHdac6EstradiolMapk14Gtf2bEsr1Gtf2h4Pik3caPolr2aHdac1EstradiolSos1Hdac3Bcl2Gtf2f2GperCreb1Esr1FosTaf13Shc2Brca1Esr1Polr2bPolr2eTaf5Elk1Mapk9Mapk1Esr1Gngt1Polr2cIlkGnb1EstradiolHdac4Polr2iEstradiolEstradiolEsr1Taf9Ercc3EstradiolBcl2Map2k1CcnhHdac2Ncor1Ep300PrkacaTaf12IkbkbGnasChukCcnd1BrafTbpCdk7EstradiolGtf2h1Hras1Gtf2h2Esr1Taf6Esr1TbpIkbkgGtf2h3Grb2EstradiolPolr2fEstradiolPolr2kCreb1Sp1Gtf2e2Nfkb1Esr1Cyclic AMPEsr1Gtf2a2


Estrogen receptor refers to a group of receptors which are activated by the hormone 17β-estradiol (estrogen). Two types of estrogen receptor exist: ER which is a member of the nuclear hormone family of intracellular receptors and the estrogen G protein coupled receptor GPR30 (GPER), which is a G-protein coupled receptor. The main function of the estrogen receptor is as a DNA binding transcription factor which regulates gene expression. However the estrogen receptor also has additional functions independent of DNA binding.


This pathway was inferred from Homo sapiens pathway WP712(r29739) with a 98% conversion rate.

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Ontology Terms



  1. Battaglia F, Delfino S, Merello E, Puppo M, Piva R, Varesio L, Bosco MC; ''Hypoxia transcriptionally induces macrophage-inflammatory protein-3alpha/CCL-20 in primary human mononuclear phagocytes through nuclear factor (NF)-kappaB.''; J Leukoc Biol, 2008 PubMed Europe PMC Scholia
  2. Song YJ, Jen KY, Soni V, Kieff E, Cahir-McFarland E; ''IL-1 receptor-associated kinase 1 is critical for latent membrane protein 1-induced p65/RelA serine 536 phosphorylation and NF-kappaB activation.''; Proc Natl Acad Sci U S A, 2006 PubMed Europe PMC Scholia
  3. Uemura N, Kajino T, Sanjo H, Sato S, Akira S, Matsumoto K, Ninomiya-Tsuji J; ''TAK1 is a component of the Epstein-Barr virus LMP1 complex and is essential for activation of JNK but not of NF-kappaB.''; J Biol Chem, 2006 PubMed Europe PMC Scholia


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106836view13:31, 17 September 2019MaintBotHMDB identifier normalization
90713view20:19, 13 December 2016KhanspersModified title
73501view23:09, 29 January 2014KhanspersModified title
69067view18:08, 8 July 2013MaintBotUpdated to 2013 gpml schema
67207view10:21, 26 June 2013Christine ChichesterOntology Term : 'estrogen signaling pathway' added !
59014view20:33, 21 February 2013MaintBotUpdated Ensembl and UniProt data source
48233view05:32, 17 May 2012MaintBotAutomatic update of PubChem xrefs
41249view00:20, 2 March 2011MaintBotRemoved redundant pathway information and comments
32708view22:17, 2 September 2009MaintBotfixed xref
32696view17:35, 1 September 2009Khanspersadded xref
32291view13:12, 15 August 2009MaintBotFixed text labels
31849view12:31, 14 August 2009MaintBotFixed group labels
31319view20:17, 13 August 2009MaintBotFixed text labels
30828view00:00, 30 July 2009MaintBotNew pathway

External references


View all...
NameTypeDatabase referenceComment
Akt1GeneProduct11651 (Entrez Gene)
Bcl2GeneProduct12043 (Entrez Gene)
BrafGeneProduct109880 (Entrez Gene)
Brca1GeneProduct12189 (Entrez Gene)
Ccnd1GeneProduct12443 (Entrez Gene)
CcnhGeneProduct66671 (Entrez Gene)
Cdk7GeneProduct12572 (Entrez Gene)
ChukGeneProductENSMUSG00000025199 (Ensembl)
Creb1GeneProduct12912 (Entrez Gene)
CrebbpGeneProduct12914 (Entrez Gene)
Cyclic AMPMetaboliteHMDB0000058 (HMDB)
Elk1GeneProduct13712 (Entrez Gene)
Ep300GeneProduct328572 (Entrez Gene)
Ercc2GeneProduct13871 (Entrez Gene)
Ercc3GeneProduct13872 (Entrez Gene)
Esr1GeneProduct13982 (Entrez Gene)
EstradiolMetaboliteHMDB0000151 (HMDB)
FosGeneProduct14281 (Entrez Gene)
GnasGeneProduct14683 (Entrez Gene)
Gnb1GeneProduct14688 (Entrez Gene)
Gngt1GeneProduct14699 (Entrez Gene)
GperGeneProduct76854 (Entrez Gene)
Grb2GeneProduct14784 (Entrez Gene)
Gtf2a2GeneProduct235459 (Entrez Gene)
Gtf2bGeneProduct229906 (Entrez Gene)
Gtf2e1GeneProduct74197 (Entrez Gene)
Gtf2e2GeneProduct68153 (Entrez Gene)
Gtf2f2GeneProduct68705 (Entrez Gene)
Gtf2h1GeneProduct14884 (Entrez Gene)
Gtf2h2GeneProduct23894 (Entrez Gene)
Gtf2h3GeneProduct209357 (Entrez Gene)
Gtf2h4GeneProduct14885 (Entrez Gene)
Hdac1GeneProduct433759 (Entrez Gene) HDAC1; histone deacetylase 1
Hdac2GeneProduct15182 (Entrez Gene) HDAC2; histone deacetylase 2
Hdac3GeneProduct15183 (Entrez Gene) HDAC3; histone deacetylase 3
Hdac4GeneProduct208727 (Entrez Gene) HDAC4; histone deacetylase 4
Hdac5GeneProduct15184 (Entrez Gene) HDAC5; histone deacetylase 5
Hdac6GeneProduct15185 (Entrez Gene) HDAC6; histone deacetylase 6
Hdac7GeneProduct56233 (Entrez Gene) HDAC7A; histone deacetylase 7
Hdac8GeneProduct70315 (Entrez Gene) HDAC8; histone deacetylase
Hras1GeneProductENSMUSG00000025499 (Ensembl)
IkbkbGeneProductENSMUSG00000031537 (Ensembl)
IkbkgGeneProductENSMUSG00000004221 (Ensembl)
IlkGeneProduct16202 (Entrez Gene)
JunGeneProduct16476 (Entrez Gene)
Map2k1GeneProductENSMUSG00000004936 (Ensembl)
Mapk14GeneProduct26416 (Entrez Gene)
Mapk1GeneProductENSMUSG00000063358 (Ensembl)
Mapk9GeneProduct26420 (Entrez Gene)
Mnat1GeneProduct17420 (Entrez Gene)
Ncor1GeneProduct20185 (Entrez Gene)
Nfkb1GeneProduct18033 (Entrez Gene)
Pik3caGeneProduct18706 (Entrez Gene)
Polr2aGeneProduct20020 (Entrez Gene)
Polr2bGeneProduct231329 (Entrez Gene)
Polr2cGeneProduct20021 (Entrez Gene)
Polr2eGeneProduct66420 (Entrez Gene)
Polr2fGeneProduct69833 (Entrez Gene)
Polr2gGeneProduct67710 (Entrez Gene)
Polr2hGeneProduct245841 (Entrez Gene)
Polr2iGeneProduct69920 (Entrez Gene)
Polr2jGeneProduct20022 (Entrez Gene)
Polr2kGeneProduct17749 (Entrez Gene)
PrkacaGeneProduct18747 (Entrez Gene)
Shc2GeneProduct216148 (Entrez Gene)
Sin3aGeneProduct20466 (Entrez Gene)
Sos1GeneProduct20662 (Entrez Gene)
Sp1GeneProduct20683 (Entrez Gene)
SrcGeneProduct20779 (Entrez Gene)
Taf12GeneProduct66464 (Entrez Gene)
Taf13GeneProduct99730 (Entrez Gene)
Taf5GeneProduct226182 (Entrez Gene)
Taf6GeneProduct21343 (Entrez Gene)
Taf7GeneProduct24074 (Entrez Gene)
Taf9GeneProduct108143 (Entrez Gene)
TbpGeneProduct21374 (Entrez Gene)

Annotated Interactions

No annotated interactions
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