EBV LMP1 signaling (Mus musculus)

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1, 2S32-PTES2PUS36-PUPPPUS32-PS36-PTES1PChukIfnb1Ccl20Nfkb2Nfkb1Traf6RelaMap3k3ChukNfkb2Nfkb1Traf1Hsp90aa1IkbkgTnfRelaMap3k14Mapk1RelaRelaIL8Map3k7RelaI-Kappa-BMapk8Nfkb1TraddCcl5Irak1Map3k7RelaI-Kappa-BNfkb1IkbkbPdlim7SFC complex3, 4


based on science-slides...


This pathway was inferred from Homo sapiens pathway WP262(r29609) with a 88% conversion rate.

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Ontology Terms



  1. Song YJ, Jen KY, Soni V, Kieff E, Cahir-McFarland E; ''IL-1 receptor-associated kinase 1 is critical for latent membrane protein 1-induced p65/RelA serine 536 phosphorylation and NF-kappaB activation.''; Proc Natl Acad Sci U S A, 2006 PubMed Europe PMC Scholia
  2. Uemura N, Kajino T, Sanjo H, Sato S, Akira S, Matsumoto K, Ninomiya-Tsuji J; ''TAK1 is a component of the Epstein-Barr virus LMP1 complex and is essential for activation of JNK but not of NF-kappaB.''; J Biol Chem, 2006 PubMed Europe PMC Scholia
  3. Battaglia F, Delfino S, Merello E, Puppo M, Piva R, Varesio L, Bosco MC; ''Hypoxia transcriptionally induces macrophage-inflammatory protein-3alpha/CCL-20 in primary human mononuclear phagocytes through nuclear factor (NF)-kappaB.''; J Leukoc Biol, 2008 PubMed Europe PMC Scholia
  4. Lee JS, Lee JY, Son JW, Oh JH, Shin DM, Yuk JM, Song CH, Paik TH, Jo EK; ''Expression and regulation of the CC-chemokine ligand 20 during human tuberculosis.''; Scand J Immunol, 2008 PubMed Europe PMC Scholia


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89985view19:01, 6 October 2016Mkutmonfixed unconnected lines
69897view19:27, 11 July 2013Mkutmonfixed unconnected lines
69108view18:13, 8 July 2013MaintBotUpdated to 2013 gpml schema
67170view10:15, 26 June 2013Christine ChichesterOntology Term : 'Epstein-Barr virus infection pathway' added !
59031view20:41, 21 February 2013MaintBotUpdated Ensembl and UniProt data source
41295view00:23, 2 March 2011MaintBotRemoved redundant pathway information and comments
32700view18:22, 1 September 2009MaintBotNA
31848view12:31, 14 August 2009MaintBotFixed group labels
30826view00:00, 30 July 2009MaintBotNew pathway

External references


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NameTypeDatabase referenceComment
Ccl20GeneProductENSMUSG00000026166 (Ensembl)
Ccl5GeneProductENSMUSG00000035042 (Ensembl)
ChukGeneProduct12675 (Entrez Gene)
ChukGeneProductENSMUSG00000025199 (Ensembl)
Hsp90aa1GeneProduct15519 (Entrez Gene)
Ifnb1GeneProductENSMUSG00000048806 (Ensembl)
IkbkbGeneProductENSMUSG00000031537 (Ensembl)
IkbkgGeneProductENSMUSG00000004221 (Ensembl)
Irak1GeneProductENSMUSG00000031392 (Ensembl)
Map3k14GeneProductENSMUSG00000020941 (Ensembl)
Map3k3GeneProductENSMUSG00000020700 (Ensembl)
Map3k7GeneProductENSMUSG00000028284 (Ensembl)
Mapk1GeneProductENSMUSG00000063358 (Ensembl)
Mapk8GeneProductENSMUSG00000021936 (Ensembl)
Nfkb1GeneProductENSMUSG00000028163 (Ensembl)
Nfkb2GeneProductENSMUSG00000025225 (Ensembl)
Pdlim7GeneProductENSMUSG00000021493 (Ensembl)
RelaGeneProductENSMUSG00000024927 (Ensembl)
SFC complexGeneProduct
TnfGeneProductENSMUSG00000024401 (Ensembl)
TraddGeneProductENSMUSG00000031887 (Ensembl)
Traf1GeneProductENSMUSG00000026875 (Ensembl)
Traf6GeneProductENSMUSG00000027164 (Ensembl)

Annotated Interactions

No annotated interactions
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