Hedgehog Signaling Pathway (Mus musculus)

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1, 2GlycosylationDemethylationLigandMolecular AssociationInhibitionPM->ENDPalmitoylationControlDesumoylationUbiquitinationDeubiquitinationDephosphorylationNUActivationERRecruitmentPhosphorylationENCY->NUEnzyme complexGene SymbolTranslocationCY->NUCytoplasmMolecule in the pathwayPMGOCY->NUProteins in a complex interactionCY->NUPlasma membraneNucleusExtracellularDSumoylationMethylationMitochondrionCY->PMReaction through unknown mechanisms/moleculesECMTReceptorCYDeacetylationAccession Number: NetPath 10; cellmap:10AutophosphorylationAcetylationEndosomePM->ENProteolytic cleavageEndoplasmic reticulum(Protein-protein interaction)Golgi apparatusCY->NUDSAP18Ptch2Gas1Igf2SmoShhSkiGli2HhipDhhHhipCdc2aStk36CCNB1Gli1Rab23SufuShhIhhPtch1Cdc2aHhipPtch2ShhCCNB1SufuDyrk1aSin3aGli1SufuDhhRab23Ptch2Ptch1IhhPtch1IhhGli2Gli3Gli3ShhSmoCrebbpDhhPtch1


The Hedgehog proteins are a family of secreted ligands that include sonic hedgehog, Indian hedgehog and desert hedgehog in humans. Binding of Hedgehog ligands to their receptors, Patched 1 and 2, prevents inhibition of a 7 transmembrane receptor called Smoothened. This leads to activation of GLI family of transcription factors (GLI1-3). Signaling through the Hedgehog pathway is essential for development of many tissues and organs. This pathway is highly conserved among metazoans. Aberrant activation of this pathway has been associated with a number of human malignancies including carcinoma of lung, esophagus, pancreas and prostate. Source: NetPath http://www.netpath.org/pathways?path_id=NetPath_10


GenMAPP notes 
NetPath:10 ; cellmap:10 - Hedgehog Signaling Pathway

This cancer signaling pathway is available at Cancer Cell Map (http://cancer.cellmap.org) and NetPath (http://www.netpath.org) and is part of a collaborative project between the Computational Biology Center at Memorial Sloan-Kettering Cancer Center (http://cbio.mskcc.org), PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the Cancer Cell Map and NetPath websites until the pathway is published.

GenMAPP remarks 
http://cancer.cellmap.org; http://www.netpath.org
This pathway was inferred from Homo sapiens pathway WP47(r20775) with a 93% conversion rate.

Quality Tags

Ontology Terms



  1. Lum L, Beachy PA; ''The Hedgehog response network: sensors, switches, and routers.''; Science, 2004 PubMed Europe PMC Scholia
  2. Mohler J; ''Requirements for hedgehod, a segmental polarity gene, in patterning larval and adult cuticle of Drosophila.''; Genetics, 1988 PubMed Europe PMC Scholia


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111021view14:34, 30 June 2020L DupuisConverted interaction lines in legend to graphical lines
69142view18:16, 8 July 2013MaintBotUpdated to 2013 gpml schema
67327view10:37, 26 June 2013Christine ChichesterOntology Term : 'Hedgehog signaling pathway' added !
41332view00:25, 2 March 2011MaintBotRemoved redundant pathway information and comments
35737view23:47, 12 February 2010AlexanderPico
35736view23:47, 12 February 2010AlexanderPicoadding description and refs
34400view23:00, 9 December 2009MaintBotAutomatic update of empty xrefs
31277view20:01, 13 August 2009MaintBotFixed text labels
30862view00:11, 30 July 2009MaintBotConverted from Homo sapiens
20927view11:30, 14 November 2008MaintBot[[Pathway:Mus musculus:Hedgehog Netpath 10]] moved to [[Pathway:WP116]]: Moved to stable identifier
8128view13:46, 7 January 2008MaintBot[[Pathway:Mouse:Hedgehog Netpath 10]] moved to [[Pathway:Mus musculus:Hedgehog Netpath 10]]: Renaming species
7685view16:09, 18 December 2007MaintBotfixed category names
7236view12:41, 4 November 2007MaintBotAdded categories to GPML
6455view22:19, 22 May 2007A.Pandeygpml file for [[Mouse:Hedgehog_Netpath_10]]

External references


View all...
NameTypeDatabase referenceComment
CCNB1GeneProduct268697 (Entrez Gene)
Cdc2aGeneProduct12534 (Entrez Gene)
CrebbpGeneProduct12914 (Entrez Gene)
DhhGeneProduct13363 (Entrez Gene)
Dyrk1aGeneProduct13548 (Entrez Gene)
Gas1GeneProduct14451 (Entrez Gene)
Gli1GeneProduct14632 (Entrez Gene)
Gli2GeneProduct14633 (Entrez Gene)
Gli3GeneProduct14634 (Entrez Gene)
HhipGeneProduct15245 (Entrez Gene)
Igf2GeneProduct16002 (Entrez Gene)
IhhGeneProduct16147 (Entrez Gene)
Ptch1GeneProduct19206 (Entrez Gene)
Ptch2GeneProduct19207 (Entrez Gene)
Rab23GeneProduct19335 (Entrez Gene)
SAP18GeneProduct20220 (Entrez Gene)
ShhGeneProduct20423 (Entrez Gene)
Sin3aGeneProduct20466 (Entrez Gene)
SkiGeneProduct20481 (Entrez Gene)
SmoGeneProduct319757 (Entrez Gene)
Stk36GeneProduct269209 (Entrez Gene)
SufuGeneProduct24069 (Entrez Gene)

Annotated Interactions

No annotated interactions
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