TGF Beta Signaling Pathway (Mus musculus)

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1, 2RepressorsCofactorsAccessory receptors:CofactorCo-SmadsR-Smadsligands:RsmadsCo-smadsTGFbSmad9Zfyve9Tgfbr3Tgfbr1Smad4Tgfbr1Bmp4Jak1Runx2Tgfbr2Ltbp1InhbaStat1Mapk3Itgb6Tgif1Zeb2Smad7SkiRunx3JunLef1Smad1Serpine1Hras1Smad2NogSmad2Stat3Mapk9Foxh1Zfp423BambiTgfb1TnfSmad6EgfFosTcfe3Thbs1Nfkb1Wnt1Ep300SkilTnfBmp4Tgfb1FstCtnnb1CrebbpSmad3EngSpp1LifTgfbr2Smad1IfngSmad5Fkbp1a


The Transforming growth factor beta (TGFβ) signaling pathway is involved in many cellular processes in both the adult organism and the developing embryo including cell growth, cell differentiation, apoptosis, cellular homeostasis and other cellular functions. In spite of the wide range of cellular processes that the TGFβ signaling pathway regulates, the process is relatively simple. TGFβ superfamily ligands bind to a type II receptor, which recruits and phosphorylates a type I receptor. The type I receptor then phosphorylates receptor-regulated SMADs (R-SMADs) which can now bind the coSMAD SMAD4. R-SMAD/coSMAD complexes accumulate in the nucleus where they act as transcription factors and participate in the regulation of target gene expression. (source: WikiPedia). Also see: TGF-beta receptor signaling at the NCI-Nature pathway interaction database.


GenMAPP remarks 
edited by: Nathan Salomonis
This pathway was inferred from Homo sapiens pathway WP560(r30273) with a 100% conversion rate.

Quality Tags

Ontology Terms



  1. Massague J; ''How cells read TGF-beta signals.''; Nat Rev Mol Cell Biol, 2000 PubMed Europe PMC Scholia
  2. Massague J, Blain SW, Lo RS; ''TGFbeta signaling in growth control, cancer, and heritable disorders.''; Cell, 2000 PubMed Europe PMC Scholia


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109428view09:25, 17 March 2020L DupuisDeleted unconnected line with no function and converted an unconnected interaction line to a graphical line
69818view14:35, 11 July 2013Cizarfixed unconnected lines
69083view18:10, 8 July 2013MaintBotUpdated to 2013 gpml schema
67692view11:50, 26 June 2013DdiglesOntology Term : 'transforming growth factor-beta superfamily mediated signaling pathway' added !
41270view00:21, 2 March 2011MaintBotRemoved redundant pathway information and comments
31754view12:04, 14 August 2009MaintBotFixed group labels
30883view00:17, 30 July 2009MaintBotConverted from Homo sapiens
20921view11:30, 14 November 2008MaintBot[[Pathway:Mus musculus:TGF Beta Signaling Pathway]] moved to [[Pathway:WP113]]: Moved to stable identifier
8442view13:46, 7 January 2008MaintBot[[Pathway:Mouse:TGF Beta Signaling Pathway]] moved to [[Pathway:Mus musculus:TGF Beta Signaling Pathway]]: Renaming species
7837view16:21, 18 December 2007MaintBotfixed category names
7302view12:42, 4 November 2007MaintBotAdded categories to GPML
6502view22:19, 22 May 2007N.Galgpml file for [[Mouse:TGF_Beta_Signaling_Pathway]]

External references


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NameTypeDatabase referenceComment
BambiGeneProduct68010 (Entrez Gene)
Bmp4GeneProduct12159 (Entrez Gene)
CrebbpGeneProduct12914 (Entrez Gene)
Ctnnb1GeneProduct12387 (Entrez Gene)
EgfGeneProduct13645 (Entrez Gene)
EngGeneProduct13805 (Entrez Gene)
Ep300GeneProduct328572 (Entrez Gene)
Fkbp1aGeneProduct14225 (Entrez Gene)
FosGeneProduct14281 (Entrez Gene)
Foxh1GeneProduct14106 (Entrez Gene)
FstGeneProduct14313 (Entrez Gene)
Hras1GeneProduct15461 (Entrez Gene)
IfngGeneProduct15978 (Entrez Gene)
InhbaGeneProduct16323 (Entrez Gene)
Itgb6GeneProduct16420 (Entrez Gene)
Jak1GeneProduct16451 (Entrez Gene)
JunGeneProduct16476 (Entrez Gene)
Lef1GeneProduct16842 (Entrez Gene)
LifGeneProduct16878 (Entrez Gene)
Ltbp1GeneProduct268977 (Entrez Gene)
Mapk3GeneProduct26417 (Entrez Gene)
Mapk9GeneProduct26420 (Entrez Gene)
Nfkb1GeneProduct18033 (Entrez Gene)
NogGeneProduct18121 (Entrez Gene)
Runx2GeneProduct12393 (Entrez Gene)
Runx3GeneProduct12399 (Entrez Gene)
Serpine1GeneProduct18787 (Entrez Gene)
SkiGeneProduct20481 (Entrez Gene)
SkilGeneProduct20482 (Entrez Gene)
Smad1GeneProduct17125 (Entrez Gene)
Smad2GeneProduct17126 (Entrez Gene)
Smad3GeneProduct17127 (Entrez Gene)
Smad4GeneProduct17128 (Entrez Gene)
Smad5GeneProduct17129 (Entrez Gene)
Smad6GeneProduct17130 (Entrez Gene)
Smad7GeneProduct17131 (Entrez Gene)
Smad9GeneProduct55994 (Entrez Gene)
Spp1GeneProduct20750 (Entrez Gene)
Stat1GeneProduct20846 (Entrez Gene)
Stat3GeneProduct20848 (Entrez Gene)
Tcfe3GeneProduct209446 (Entrez Gene)
Tgfb1GeneProduct21803 (Entrez Gene)
Tgfbr1GeneProduct21812 (Entrez Gene)
Tgfbr2GeneProduct21813 (Entrez Gene)
Tgfbr3GeneProduct21814 (Entrez Gene)
Tgif1GeneProduct21815 (Entrez Gene)
Thbs1GeneProduct21825 (Entrez Gene) there are 5 types of tsp
TnfGeneProduct21926 (Entrez Gene)
Wnt1GeneProduct22408 (Entrez Gene)
Zeb2GeneProduct24136 (Entrez Gene)
Zfp423GeneProduct94187 (Entrez Gene)
Zfyve9GeneProduct230597 (Entrez Gene)

Annotated Interactions

No annotated interactions
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