DNA Replication (Canis familiaris)

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1-3Processive complexOrc complexPrimaseRNA primer-DNA primer:origin duplex:PCNAOrc1Mcm3RFC37Mcm3UbiquitinMcm4Mcm5RFC Heteropentamer:RNA primer-DNA primer1. Assembly of the pre-replicative complexOrc5Ubiquitinated Cdc6Cdc6Mcm 4,6,7 trimer forms andassociates with the replication forkRNA PrimerCdt1GemininMcm4Cdc6Cdt1Mcm2Cdc6Cdc6Degraded byproteasomein cytosolMcm10RFC38p70Orc3Orc4RFC40Phosphorylated Orc12. Activation of the pre-replicative complexCdt1Pre-replicative complexDNA polymerase alpha:primase: origin complexPhosphorylated Cdc6RFC140Orc5Orc3OriginOrc3Mcm7Orc2Pre-replicative complexUbiquitinated Orc1Orc2Mcm6RFC Heteropentamer:RNA primer-DNA primerPCNA homotrimerOrc2Orc complexOrc5DNAPolymerase AMcm2Orc35. Leading/lagging strand synthesisOrc complex4. Switching of origins to post-replicative statep180Mcm6RFC36Orc complexMcm5RNA primer-DNA primerCdt1p58Degraded by proteasome in cytosolOrc4Cdt1Mcm10Orc complexUbiquitinDNA polymerase alpha:primase: origin complexp49RNA primer-DNA primerOrc23. DNA replication initiationPhosphorylation ofMcm 2-7 complexMcm7ATPADPCDK2ATPGMNNUBA52MCM4ORC5LRFC4RPA2MCM5MCM7RPA4MCM3UBCPOLD3MCM10PRIM1MCM2CTPdCTPDBF4GTPORC1LPCNACDT1MCM6ORC3LUTPADPATPORC4LPOLD2RPA3ORC2LRFC1CDC45LPOLD1ATPCDC6ORC6LPOLA2POLA1RPA1POLE2dUTPPOLD4RFC2RFC3dGTPdATPPRIM2CDC7RFC5POLE


DNA replication, the basis for biological inheritance, is a fundamental process occurring in all living organisms to copy their DNA. This process is "replication" in that each strand of the original double-stranded DNA molecule serves as template for the reproduction of the complementary strand. Hence, following DNA replication, two identical DNA molecules have been produced from a single double-stranded DNA molecule. Cellular proofreading and error-checking mechanisms ensure near perfect fidelity for DNA replication. Source: Wikipedia


GenMAPP notes 
GenMAPP remarks 
Based on www.reactome.org
This pathway was inferred from Homo sapiens pathway WP466(r21660) with a 74% conversion rate.

Quality Tags

Ontology Terms



  1. Kelly TJ, Brown GW; ''Regulation of chromosome replication.''; Annu Rev Biochem, 2000 PubMed Europe PMC Scholia
  2. Bell SP, Dutta A; ''DNA replication in eukaryotic cells.''; Annu Rev Biochem, 2002 PubMed Europe PMC Scholia
  3. Cimbora DM, Groudine M; ''The control of mammalian DNA replication: a brief history of space and timing.''; Cell, 2001 PubMed Europe PMC Scholia


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71479view19:18, 17 October 2013MaintBotAutomated update of data sources
68572view22:58, 5 July 2013MaintBotUpdated to 2013 gpml schema
67157view10:14, 26 June 2013Christine ChichesterOntology Term : 'DNA replication pathway' added !
40730view21:53, 1 March 2011MaintBotRemoved redundant pathway information and comments
35221view15:53, 11 February 2010Thomasadded literature
35207view15:43, 11 February 2010ThomasModified description
34009view18:41, 9 December 2009MaintBotAutomatic update of empty xrefs
32545view13:04, 17 August 2009MaintBotFixed text labels
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External references


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NameTypeDatabase referenceComment
CDC45LGeneProduct486421 (Entrez Gene)
CDC6GeneProduct480527 (Entrez Gene)
CDC7GeneProduct479955 (Entrez Gene)
CDK2GeneProduct606931 (Entrez Gene)
CDT1GeneProduct479616 (Entrez Gene)
DBF4GeneProduct475219 (Entrez Gene)
GMNNGeneProduct478739 (Entrez Gene)
MCM10GeneProduct487128 (Entrez Gene)
MCM2GeneProduct484622 (Entrez Gene)
MCM3GeneProduct481839 (Entrez Gene)
MCM4GeneProduct477871 (Entrez Gene)
MCM5GeneProduct610519 (Entrez Gene)
MCM6GeneProduct476131 (Entrez Gene)
MCM7GeneProduct479737 (Entrez Gene)
ORC1LGeneProduct475351 (Entrez Gene)
ORC2LGeneProduct478868 (Entrez Gene)
ORC3LGeneProduct474991 (Entrez Gene)
ORC4LGeneProduct476141 (Entrez Gene)
ORC5LGeneProduct609937 (Entrez Gene)
ORC6LGeneProduct482492 (Entrez Gene)
PCNAGeneProduct477166 (Entrez Gene)
POLA1GeneProduct480869 (Entrez Gene)
POLA2GeneProduct476025 (Entrez Gene)
POLD1GeneProduct610047 (Entrez Gene)
POLD2GeneProduct482686 (Entrez Gene)
POLD3GeneProduct476806 (Entrez Gene)
POLD4GeneProduct611847 (Entrez Gene)
POLE2GeneProduct608973 (Entrez Gene)
POLEGeneProduct486223 (Entrez Gene)
PRIM1GeneProduct607309 (Entrez Gene)
PRIM2GeneProduct474950 (Entrez Gene)
RFC1GeneProduct479112 (Entrez Gene)
RFC2GeneProduct489798 (Entrez Gene)
RFC3GeneProduct477308 (Entrez Gene)
RFC4GeneProduct478667 (Entrez Gene)
RFC5GeneProduct477499 (Entrez Gene)
RPA1GeneProduct491196 (Entrez Gene)
RPA2GeneProduct487339 (Entrez Gene)
RPA3GeneProduct481449 (Entrez Gene)
UBA52GeneProduct403722 (Entrez Gene)
UBCGeneProduct610457 (Entrez Gene)

Annotated Interactions

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