Translation Factors (Homo sapiens)

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143S Pre-initiation ComplexscanningTermination60S Subunitm7GInitiationRecruitment of 60S subunitand first peptide bondBinds aminoacyl-tRNARecruitment of 43SPre-initiation ComplexTranslocationmRNA40S SubunitElongationAUGAAAAAAAAAAAAAAAGuanine Nucleotide ExchangeCap Binding ComplexEIF2B1EIF2B3EIF5BEEF1A2EIF2S2EIF1AXEIF4EBP2ITGB4BPEEF1B2EIF3S7EIF3S10EEF1DEIF4A2EIF2B5ETF1WBSCR1SUI1EIF2B4EIF4G1EIF3S2EIF2AK1EIF5EIF1AYEIF4BEIF3S1KIAA0664EIF4G3EIF3S5EIF2AK3EIF4EBP1EIF2B2EEF2KEIF4A1SUI1EEF1GEIF3S9EIF4EBP3GSPT2EIF2AK2EIF2S1EIF3S8EEF2EEF1A1EIF3S4PABPC1EIF4EEIF5AEIF3S3PAIP1EIF2S3EIF3S6


Protein synthesis is the ultimate step of gene expression and a key control point for regulation. In particular, it enables cells to rapidly manipulate protein production without new mRNA synthesis, processing, or export. This pathway gives an overview of the translation factors involved in this process.

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Ontology Terms



  1. Dever TE; ''Gene-specific regulation by general translation factors.''; Cell, 2002 PubMed


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89328view09:52, 4 September 2016Mkutmonfix unconnected lines
78489view10:28, 7 January 2015MaintBotadded missing graphIds
69767view11:28, 11 July 2013Mkutmonreplace annotation lines with graphical lines (instead of interactions)
68881view17:25, 8 July 2013MaintBotUpdated to 2013 gpml schema
45069view20:11, 6 October 2011KhanspersOntology Term : 'translation pathway' added !
41026view23:13, 1 March 2011MaintBotRemoved redundant pathway information and comments
38845view17:44, 24 September 2010Khanspers
37349view18:08, 28 May 2010Khanspersconnectors
35489view12:30, 12 February 2010MichielModified description
35485view12:26, 12 February 2010MichielAdded ref
32212view12:43, 15 August 2009MaintBotFixed text labels
31702view11:50, 14 August 2009MaintBotFixed group labels
29787view20:56, 2 June 2009Khansperslayout changes
20907view11:30, 14 November 2008MaintBot[[Pathway:Homo sapiens:Translation Factors]] moved to [[Pathway:WP107]]: Moved to stable identifier
14917view14:58, 24 May 2008MartijnVanIersellinked up
13016view11:06, 17 May 2008MaintBotSticky edges patch by Sjoerd
8452view13:46, 7 January 2008MaintBot[[Pathway:Human:Translation Factors]] moved to [[Pathway:Homo sapiens:Translation Factors]]: Renaming species
7842view16:22, 18 December 2007MaintBotfixed category names
7310view12:42, 4 November 2007MaintBotAdded categories to GPML
6400view22:18, 22 May 2007Kdahlquistgpml file for [[Human:Translation_Factors]]

External references


View all...
NameTypeDatabase referenceComment
EEF1A1GeneProduct1915 (Entrez Gene)
EEF1A2GeneProduct1917 (Entrez Gene)
EEF1B2GeneProduct1933 (Entrez Gene)
EEF1DGeneProduct1936 (Entrez Gene)
EEF1GGeneProduct1937 (Entrez Gene)
EEF2GeneProduct1938 (Entrez Gene)
EEF2KGeneProduct29904 (Entrez Gene)
EIF1AXGeneProduct1964 (Entrez Gene)
EIF1AYGeneProduct9086 (Entrez Gene)
EIF2AK1GeneProduct27102 (Entrez Gene)
EIF2AK2GeneProduct5610 (Entrez Gene) now E2K2 HUMAN
EIF2AK3GeneProduct9451 (Entrez Gene)
EIF2B1GeneProduct1967 (Entrez Gene)
EIF2B2GeneProduct8892 (Entrez Gene)
EIF2B3GeneProduct8891 (Entrez Gene)
EIF2B4GeneProduct8890 (Entrez Gene)
EIF2B5GeneProduct8893 (Entrez Gene)
EIF2S1GeneProduct1965 (Entrez Gene)
EIF2S2GeneProduct8894 (Entrez Gene)
EIF2S3GeneProduct1968 (Entrez Gene)
EIF3S10GeneProduct8661 (Entrez Gene)
EIF3S1GeneProduct8669 (Entrez Gene)
EIF3S2GeneProduct8668 (Entrez Gene)
EIF3S3GeneProduct8667 (Entrez Gene)
EIF3S4GeneProduct8666 (Entrez Gene)
EIF3S5GeneProduct8665 (Entrez Gene)
EIF3S6GeneProduct3646 (Entrez Gene)
EIF3S7GeneProduct8664 (Entrez Gene)
EIF3S8GeneProduct8663 (Entrez Gene)
EIF3S9GeneProduct8662 (Entrez Gene)
EIF4A1GeneProduct1973 (Entrez Gene)
EIF4A2GeneProduct1974 (Entrez Gene)
EIF4BGeneProduct1975 (Entrez Gene)
EIF4EGeneProduct1977 (Entrez Gene)
EIF4EBP1GeneProduct1978 (Entrez Gene)
EIF4EBP2GeneProduct1979 (Entrez Gene)
EIF4EBP3GeneProduct8637 (Entrez Gene)
EIF4G1GeneProduct1981 (Entrez Gene) TrEMBL accession number O43177 refers to same protein.
EIF4G3GeneProduct8672 (Entrez Gene)
EIF5GeneProduct1983 (Entrez Gene)
EIF5AGeneProduct1984 (Entrez Gene)
EIF5BGeneProduct9669 (Entrez Gene)
ETF1GeneProduct2107 (Entrez Gene)
GSPT2GeneProduct23708 (Entrez Gene)
ITGB4BPGeneProduct3692 (Entrez Gene)
KIAA0664GeneProduct23277 (Entrez Gene)
PABPC1GeneProduct26986 (Entrez Gene)
PAIP1GeneProduct10605 (Entrez Gene)
SUI1GeneProduct10209 (Entrez Gene)
WBSCR1GeneProduct7458 (Entrez Gene)

Annotated Interactions

No annotated interactions

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