Complement and Coagulation Cascades (Bos taurus)

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ThrombinCross-linkedfibrin polymerLectin PathwayAlternative PathwayCoagulation CascadeC3b/4b, C3b, C3dDegradationVascular injuryC3ConvertasePlatelet, monocyte,lymphocyte,endothelial cells,smooth muscle cellsactivation, etcZymosan,insulin, etc.ClotC4b/2afibrin degradationproductsC3b/BbClassical PathwayC3bC5aExtrinsic pathwayMediatorsMuscle contraction,Chemotaxis,Phagocyte recruitmentInflammation, etc.Cell adhesion,migration,proliferation, etcCell adhesion,migration,proliferation, etcC4aKinin kallikrein systemAntibody/antigencomplexCollagen,basement membrane,activated platelets, etc.C3amembrane attack complexComplement CascadeCell lysisFibrinolytic systemC1SC4CR1BradykininMASP2C3CD55Daf2KLKB1CRRYPLATPROCCD59ASERPINE1SERPINC1C1QBF3SERPING1CPB2CLUFibrin monomerKNG1A2MMASP1CFIC8GC1RPLAUC5AR1CFHPLAURBDKRB1C9F12THBD109821F5F7C2CR2SERPINA5F10TFPIF8MCPFGBC7C1QACFBCLTCVWFLMAN1F13BSERPINA1F2PLGCFDF9C3AR1SERPINF2C6C1QCF2RPROS1SERPIND1


Description

Blood coagulation is a series of coordinated and calcium-dependent proenzyme-to-serine protease conversions likely to be localized on the surfaces of activated cells in vivo. It culminates in the formation of thrombin, the enzyme responsible for the conversion of soluble fibrinogen to the insoluble fibrin clot.

The kallikrein-kinin system is an endogenous metabolic cascade, triggering of which results in the release of vasoactive kinins (bradykinin-related peptides). Kinin peptides are implicated in many physiological and pathological processes including the regulation of blood pressure and sodium homeostasis, inflammatory processes, and the cardioprotective effects of preconditioning. Complement is a system of plasma proteins that is activated by the presence of pathogens. There are three pathways of complement activation: the classical pathway, the lectin pathway, and the alternative pathway. All of these pathways generate a crucial enzymatic activity that, intern, generates the effector molecules of complement. The three main consequences of complement activation are the opsonization of pathogens, the recruitment of inflammatory and immunocompetent cells, and the direct killing of pathogens.

Source: KEGG (http://www.genome.jp/dbget-bin/www_bget?pathway:map04610)

Comments

HomologyMapper 
This pathway was inferred from Homo sapiens pathway WP558 (r95109) with a 88.0% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

No bibliography


History

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CompareRevisionActionTimeUserComment
95800view14:46, 19 January 2018MkutmonHomology conversion update
80847view15:28, 30 June 2015Mkutmonhomology conversion
79847view07:34, 19 April 2015EgonwReplaced "Ensemble Cow" with "Ensembl".
79148view06:14, 5 March 2015KhanspersUpdated conversion from Hs
71400view19:00, 17 October 2013MaintBotAutomated update of data sources
63325view21:07, 9 May 2013MaintBotUpdated to 2013 gpml schema
40506view19:28, 1 March 2011MaintBotRemoved redundant pathway information and comments
38704view19:27, 23 September 2010AlexanderPico
33749view23:58, 8 December 2009MaintBotAutomatic update of empty xrefs
32517view12:54, 17 August 2009MaintBotFixed text labels
32203view12:39, 15 August 2009MaintBotFixed text labels
31688view11:46, 14 August 2009MaintBotFixed group labels
31215view19:38, 13 August 2009MaintBotFixed text labels
30625view22:24, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
A2MGeneProduct
BDKRB1GeneProductENSBTAG00000007052 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:623
BradykininMetabolite58-82-2 (CAS)
C1QAGeneProductENSBTAG00000007153 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:712
C1QBGeneProductENSBTAG00000011196 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:713
C1QCGeneProductENSBTAG00000011193 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:714
C1RGeneProductENSBTAG00000037743 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:715
C1SGeneProductENSBTAG00000004840 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:716
C2GeneProductENSBTAG00000007450 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:717
C3AR1GeneProductENSBTAG00000019741 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:719
C3GeneProductENSBTAG00000017280 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:718
C4GeneProductENSBTAG00000037533 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:721
C5AR1GeneProductENSBTAG00000020872 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:728
C6GeneProductENSBTAG00000014177 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:729
C7GeneProductENSBTAG00000011766 (Ensembl)
  • MGI:88235 LL:109828
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:730
C8GGeneProductENSBTAG00000010520 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:733
C9GeneProductENSBTAG00000016149 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:735
CD55GeneProductENSBTAG00000006984 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1604
CD59AGeneProduct
CFBGeneProductENSBTAG00000046158 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:629
CFDGeneProductENSBTAG00000048122 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1675
CFHGeneProductENSBTAG00000023177 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:3075
CFIGeneProductENSBTAG00000034501 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:3426
CLTCGeneProductENSBTAG00000016708 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1213
CLUGeneProductENSBTAG00000015027 (Ensembl)
  • CLU
  • Type your comment here
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1191
CPB2GeneProductENSBTAG00000007073 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1361
CR1GeneProductNo homologues found for original id L:1378
CR2GeneProductENSBTAG00000038496 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1380
CRRYGeneProduct
Daf2GeneProduct
F10GeneProductENSBTAG00000016385 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:2159
F12GeneProductENSBTAG00000018872 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:2161
F13BGeneProductENSBTAG00000000070 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:2165
F2GeneProductENSBTAG00000007148 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:2147
F2RGeneProductENSBTAG00000020199 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:2149
F3GeneProductENSBTAG00000007101 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:2152
F5GeneProductENSBTAG00000017722 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:2153
F7GeneProductENSBTAG00000007411 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:2155
F8GeneProductENSBTAG00000010726 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:2157
F9GeneProductENSBTAG00000004003 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:2158
FGBGeneProductENSBTAG00000022120 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:2244
Fibrin monomerMetabolite9001-31-4 (CAS)
KLKB1GeneProductENSBTAG00000009501 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:3818
KNG1GeneProductENSBTAG00000005122 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:3827
LMAN1GeneProductENSBTAG00000006833 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:3998
MASP1GeneProductENSBTAG00000012467 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5648
MASP2GeneProductENSBTAG00000012808 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:10747
MCPGeneProductENSBTAG00000030910 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:4179
PLATGeneProductENSBTAG00000001244 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5327
PLAUGeneProductENSBTAG00000005947 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5328
PLAURGeneProductENSBTAG00000013125 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5329
PLGGeneProductENSBTAG00000001271 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5340
PROCGeneProductENSBTAG00000003950 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5624
PROS1GeneProductENSBTAG00000023652 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5627
SERPINA1GeneProductENSBTAG00000018843 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5265
SERPINA5GeneProductENSBTAG00000004063 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5104
SERPINC1GeneProductENSBTAG00000004362 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:462
SERPIND1GeneProductENSBTAG00000013973 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:3053
SERPINE1GeneProductENSBTAG00000014465 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5054
SERPINF2GeneProductENSBTAG00000020859 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5345
SERPING1GeneProductENSBTAG00000016267 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:710
TFPIGeneProductNo homologues found for original id L:7035
THBDGeneProductENSBTAG00000002758 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:7056
VWFGeneProductENSBTAG00000012265 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:7450
109821GeneProduct

Annotated Interactions

No annotated interactions
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