Glycolysis and Gluconeogenesis (Bos taurus)

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1CytosolGlycolysisMitochondrionGluconeogenesisPGAM2LDHBLDHAL6BHK3PKM2GlucosePCPFKPSLC2A2PFKMGOT1PDHBGPI1,3BP-GlycerateSLC2A3Fructose 6PALDOAFBP1Triglyceride synthesisALDOBPGK1ALDOCENO2LDHAPFKLGlucose-6PMDH13P-GlycerateGAPDHSLC2A4PDHA1Fructose-1,6BPPDHXMalateDLATMPC1TPI1DLDOxaloacetatePDHA2Glyceraldehyde 3PG6PCGAPDHSENO3MPC2PKLRPKM2PGK2PGAM1OxaloacetateSLC2A1HK1ENO1PyruvateLactatePyruvateGOT2GCKLDHCMDH2Glycogen metabolismAspartateMalateAspartateTCA CycleDihydroxyacetone-PGlucosePentose Phosphate PathwayAcetyl-CoAP-enolpyruvatePCK1SLC2A52P-GlycerateFBP2HK2


Description

Glycolysis is the metabolic pathway that converts glucose C6H12O6, into pyruvate, CH3COCOO− + H+. The free energy released in this process is used to form the ATP and NADH.

Gluconeogenesis is a metabolic pathway that results in the generation of glucose from non-carbohydrate carbon substrates such as pyruvate, lactate, glycerol, glucogenic amino acids, and fatty acids.

Description adapted from Wikipedia.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP534(78585) with a 94.0% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

  1. Bricker DK, Taylor EB, Schell JC, Orsak T, Boutron A, Chen YC, Cox JE, Cardon CM, Van Vranken JG, Dephoure N, Redin C, Boudina S, Gygi SP, Brivet M, Thummel CS, Rutter J; ''A mitochondrial pyruvate carrier required for pyruvate uptake in yeast, Drosophila, and humans.''; Science, 2012 PubMed Europe PMC

History

View all...
CompareRevisionActionTimeUserComment
106013view11:53, 16 August 2019MaintBotHMDB identifier normalization
89816view11:51, 6 October 2016MkutmonReverted to version '15:21, 30 June 2015' by Mkutmon
89815view11:50, 6 October 2016MkutmonModified description
80683view15:21, 30 June 2015Mkutmonhomology conversion
71418view19:02, 17 October 2013MaintBotAutomated update of data sources
63378view23:07, 9 May 2013MaintBotUpdated to 2013 gpml schema
62708view23:18, 1 May 2013MaintBotUpdated UniProt data source
40550view19:31, 1 March 2011MaintBotRemoved redundant pathway information and comments
33790view00:12, 9 December 2009MaintBotAutomatic update of empty xrefs
32500view12:48, 17 August 2009MaintBotFixed text labels
32191view12:35, 15 August 2009MaintBotFixed text labels
31666view11:40, 14 August 2009MaintBotFixed group labels
31198view19:32, 13 August 2009MaintBotFixed text labels
30596view22:14, 29 July 2009MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
1,3BP-GlycerateMetaboliteHMDB0001270 (HMDB)
2P-GlycerateMetaboliteHMDB0000362 (HMDB)
3P-GlycerateMetaboliteHMDB0000807 (HMDB)
ALDOAGeneProductENSBTAG00000012927 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:226
ALDOBGeneProductENSBTAG00000015358 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:229
ALDOCGeneProductENSBTAG00000013099 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:230
Acetyl-CoAMetaboliteHMDB0001206 (HMDB)
AspartateMetaboliteHMDB0000191 (HMDB)
DLATGeneProductENSBTAG00000038327 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1737
DLDGeneProductENSBTAG00000001908 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1738
Dihydroxyacetone-PMetaboliteHMDB0001473 (HMDB)
ENO1GeneProductENSBTAG00000013411 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2023
ENO2GeneProductENSBTAG00000011274 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2026
ENO3GeneProductENSBTAG00000005534 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2027
FBP1GeneProductENSBTAG00000009733 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2203
FBP2GeneProductENSBTAG00000019554 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8789
Fructose 6PMetaboliteHMDB0000124 (HMDB)
Fructose-1,6BPMetaboliteHMDB0001058 (HMDB)
G6PCGeneProductENSBTAG00000010184 (Ensembl)
  • Not present in brain and muscle, so those organs can not produce their own glucose in the gluconeogenesis pathway
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2538
GAPDHGeneProductENSBTAG00000018554 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000111640
GAPDHSGeneProductENSBTAG00000015917 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:26330
GCKGeneProductENSBTAG00000032288 (Ensembl)
  • Gck is mainly active in liver
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2645
GOT1GeneProductENSBTAG00000011960 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2805
GOT2GeneProductENSBTAG00000007172 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2806
GPIGeneProductENSBTAG00000006396 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2821
Glucose-6PMetaboliteHMDB0001401 (HMDB)
GlucoseMetaboliteHMDB0000122 (HMDB)
Glyceraldehyde 3PMetaboliteHMDB0001112 (HMDB)
Glycogen metabolismPathwayWP500 (WikiPathways)
HK1GeneProductENSBTAG00000012380 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3098
HK2GeneProductENSBTAG00000013108 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3099
HK3GeneProductENSBTAG00000014898 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3101
LDHAGeneProductENSBTAG00000008683 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3939
LDHAL6BGeneProduct
LDHBGeneProductENSBTAG00000019603 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3945
LDHCGeneProductENSBTAG00000002488 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3948
LactateMetaboliteHMDB0000190 (HMDB)
MDH1GeneProductENSBTAG00000019295 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4190
MDH2GeneProductENSBTAG00000009462 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4191
MPC1GeneProductENSBTAG00000027879 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:51660
MPC2GeneProductENSBTAG00000020968 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:25874
MalateMetaboliteHMDB0000744 (HMDB)
OxaloacetateMetaboliteHMDB0000223 (HMDB)
P-enolpyruvateMetaboliteHMDB0000263 (HMDB)
PCGeneProductENSBTAG00000019700 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5091
PCK1GeneProductENSBTAG00000001936 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5105
PDHA1GeneProductENSBTAG00000019852 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5160
PDHA2GeneProductENSBTAG00000026250 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5161
PDHBGeneProductENSBTAG00000021724 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5162
PDHXGeneProductENSBTAG00000018261 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8050
PFKLGeneProductENSBTAG00000010658 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5211
PFKMGeneProductENSBTAG00000000286 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5213
PFKPGeneProductENSBTAG00000002683 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5214
PGAM1GeneProduct
PGAM2GeneProductENSBTAG00000014547 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5224
PGK1GeneProductENSBTAG00000000894 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5230
PGK2GeneProduct
PKLRGeneProductENSBTAG00000017056 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5313
PKM2GeneProductENSBTAG00000001601 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5315
Pentose Phosphate PathwayPathwayWP134 (WikiPathways)
PyruvateMetaboliteHMDB0000243 (HMDB)
SLC2A1GeneProductENSBTAG00000009617 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6513
SLC2A2GeneProductENSBTAG00000005386 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6514
SLC2A3GeneProductENSBTAG00000004556 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6515
SLC2A4GeneProductENSBTAG00000009190 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6517
SLC2A5GeneProductENSBTAG00000007302 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6518
TCA CyclePathwayWP78 (WikiPathways)
TPI1GeneProductENSBTAG00000019782 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7167
Triglyceride synthesisPathwayWP325 (WikiPathways)

Annotated Interactions

No annotated interactions
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