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Each month there are new pathways reviewed and approved for the official release of WikiPathways. See the Download Page to access the full collection.


June 2021

Genes associated with the development of rheumatoid arthritis (Homo sapiens)
Neuroinflammation and glutamatergic signaling (Homo sapiens)
Complement system in neuronal development and plasticity (Homo sapiens)
Fatty acid biosynthesis (Caenorhabditis elegans)
Hepatocyte growth factor receptor signaling (Gallus gallus)
Hepatocyte growth factor receptor signaling (Pan troglodytes)
Hepatocyte growth factor receptor signaling (Canis familiaris)
S1P receptor signal transduction (Canis familiaris)

May 2021

Serine Metabolism (Homo sapiens)
Peptidoglycan cytoplasmic synthesis and recycling pathways (Escherichia coli)
FOXA2 pathway (Homo sapiens)
Modulators of TCR signaling and T cell activation (Homo sapiens)
Kallmann's Syndrome (Homo sapiens)
Fatty acid transporters (Homo sapiens)

April 2021

FOXP3 in COVID-19 (Homo sapiens)
SARS-CoV-2 altering angiogenesis via NRP1 (Homo sapiens)
Soluble ACE2-mediated cell entry of SARS-CoV-2 (Homo sapiens)

March 2021

Hair Follicle Development: Organogenesis - Part 2 of 3 (Homo sapiens)
Liver steatosis AOP (Homo sapiens)
nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell (Homo sapiens)
Kynurenine Pathway and links to Cellular Senescence (Homo sapiens)
NAD Metabolism in Oncogene-Induced Senescence and Mitochondrial Dysfunction-Associated Senescence (Homo sapiens)
Nephrogenesis (Homo sapiens)
Development of ureteric collection system (Homo sapiens)
7-oxo-C and 7beta-HC pathways (Homo sapiens)

February 2021

Airway smooth muscle cell contraction (Homo sapiens)
SARS-CoV-2 mitochondrial interactions (Homo sapiens)
SARS-CoV-2 Innate Immunity Evasion and Cell-specific immune response (Homo sapiens)
Glycolysis in senescence (Homo sapiens)
TCA cycle in senescence (Homo sapiens)

January 2021

Mitochondrial fatty acid synthesis pathway (Homo sapiens)
Ethylmalonic Encephalopathy (Homo sapiens)
Biotin Metabolism (including IEMs) (Homo sapiens)
Riboflavin and CoQ disorders (Homo sapiens)

December 2020

Acetogenesis (Acetobacterium woodii)
RAS and Bradykinin pathways in COVID-19 (Homo sapiens)
Galanin receptor pathway (Homo sapiens)
CAMKK2 Pathway (Homo sapiens)
STING pathway in Kawasaki-like disease and COVID-19 (Homo sapiens)

November 2020

Deregulation of the Renin Angiotensin system by Sars-CoV infection (Mus musculus)
16p11.2 proximal deletion syndrome (Homo sapiens)
SARS-CoV-2 and COVID-19 Pathway (Homo sapiens)
aspirin and miRNAs (Homo sapiens)

October 2020

Glucocorticoid Receptor Pathway (Homo sapiens)
7q11.23 copy number variation syndrome (Homo sapiens)
DNA Repair Pathways Full Network (Homo sapiens)
16p11.2 distal deletion syndrome (Homo sapiens)
p53 transcriptional gene network (Homo sapiens)
Fluoroacetic acid toxicity (Homo sapiens)
Phosphoinositides metabolism (Homo sapiens)

September 2020

August 2020

Beta Oxidation of Unsaturated Fatty Acids (Caenorhabditis elegans)

July 2020

MAPK pathway in congenital thyroid cancer (Homo sapiens)
15q11.2 copy number variation syndrome (Homo sapiens)
Mitochondrial Complex I inhibition leading to chemical induced fanconi syndrome (Homo sapiens)
NO metabolism in cystic fibrosis (Homo sapiens)

June 2020

EGFR Tyrosine Kinase Inhibitor Resistance (Homo sapiens)
The influence of laminopathies on Wnt signaling (Homo sapiens)
Linoleic acid metabolism known to be affected by coronavirus infection (Homo sapiens)
Endoplasmic reticulum (ER) stress response in Coronavirus infection (Homo sapiens)
SARS-CoV-2 and Angiotensin-converting enzyme 2 (ACE2) receptor: Molecular mechanisms and potential therapeutic target (Homo sapiens)
LDLRAD4 and what we know about it (Homo sapiens)
3q29 copy number variation syndrome (Homo sapiens)
COVID-19, thrombosis and anticoagulation (Homo sapiens)
Direct Reversal Repair (Homo sapiens)

May 2020

Mitochondrial CIV Assembly (Homo sapiens)
Autophagy (Homo sapiens)
Unfolded protein response (Homo sapiens)
MAP3K1 role in promoting and blocking gonadal determination (Homo sapiens)
Cellular Proteostasis (Homo sapiens)
Neuroinflammation (Homo sapiens)
Mitochondrial CII Assembly (Homo sapiens)
Mitochondrial CIII assembly (Homo sapiens)
Purinergic signaling (Homo sapiens)
1q21.1 copy number variation syndrome (Homo sapiens)
SARS coronavirus and innate immunity (Homo sapiens)
Proximal tubule transport (Homo sapiens)
Somatic Sex determination (Homo sapiens)
Peroxiredoxin 2 induced ovarian failure (Homo sapiens)
Disruption of postsynaptic signalling by CNV (Homo sapiens)
Interacting Laminopathic Pathways (Homo sapiens)
Peroxiredoxin 2 induced ovarian failure (Mus musculus)
Mammalian disorder of sexual development (Homo sapiens)

April 2020

Nanomaterial-induced Inflammasome Activation (Homo sapiens)
Oxidative Stress and Redox Pathway (Mus musculus)
Downregulation of ACE2 expression by SARS-CoV infection and SARS-CoV Spike protein. (Homo sapiens)
Ciliopathies (Homo sapiens))
Cholesterol Biosynthesis with Skeletal Dysplasias (Homo sapiens)
Endochondral Ossification with Skeletal Dysplasias (Homo sapiens)
Glycosaminoglycan degradation (Homo sapiens)
Conversion of Angiotensinogen to Angiotensin II (Homo sapiens)
GDNF/RET signalling axis (Mus musculus)
Genes controlling renal nephrogenesis (Homo sapiens)
Regucalcin in proximal tubule epithelial kidney cells (Homo sapiens)
COVID-19 AOP (Homo sapiens)
Intracellular trafficking proteins involved in CMT neuropathy (Homo sapiens)
Hijack of Ubiquitination by SARS-CoV-2 (Homo sapiens)
Host-pathogen interaction of human corona viruses - autophagy (Homo sapiens)
Host-pathogen interaction of human corona viruses - apoptosis (Homo sapiens)
Type I Interferon Induction and Signaling During SARS-CoV-2 Infection (Homo sapiens)
Kisspeptin/Kisspeptin Receptor System in the Ovary (Homo sapiens)
Activation of NLRP3 Inflammasome by SARS-CoV-2 (Homo sapiens)
Pathogenesis of SARS-CoV-2 Mediated by nsp9/nsp10 Complex (Homo sapiens)
Host-pathogen interaction of human corona viruses - MAPK signaling (Homo sapiens)
Host-pathogen interaction of human corona viruses - Interferon induction (Homo sapiens)

March 2020

Proteoglycan biosynthesis (Homo sapiens)
Somitogenesis in the context of spondylocostal dysostosis (Homo sapiens)
Type I collagen synthesis in the context of Osteogenesis imperfecta (Homo sapiens)
Osteoblast differentiation (Homo sapiens)
Autosomal recessive Osteopetrosis pathways (Homo sapiens)
MED and Pseudoachondroplasia genes (Homo sapiens)
FGF23 signalling in Hypophosphatemic rickets (Homo sapiens)
mBDNF and proBDNF regulation of GABA neurotransmission (Homo sapiens)
GDNF/RET signalling axis (Homo sapiens)

February 2020

FGFR3 signalling in chondrocyte proliferation and terminal differentiation (Homo sapiens)
Purine metabolism (Homo sapiens)
Monoterpene Biosynthesis Pathway Genes in Mint (Homo sapiens)

January 2020

Vitamin D-sensitive calcium signaling in depression (Homo sapiens)
Thyroid hormones production and their peripheral downstream signalling effects regarding congenital hypothyroidism (Homo sapiens)
Netrin-UNC5B signaling Pathway (Homo sapiens)
Base Excision Repair (Homo sapiens)
Nucleotide Excision Repair (Homo sapiens)
IL-18 signaling pathway (Homo sapiens)
Renin Angiotensin Aldosterone System (RAAS) (Homo sapiens)
PKC-gamma calcium signaling pathway in ataxia (Homo sapiens)
Regulation of Pgc1a expression by a Gsk3b-Tfeb signaling axis in skeletal muscle (Mus musculus)

Prior Years

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