Portal:CPTAC

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CPTAC Pathways

Welcome to the CPTAC Pathway Portal

This portal highlights pathway content relevant to the Clinical Proteomic Tumor Analysis Consortium (CPTAC).

The National Cancer Institute, part of the National Institutes of Health, announced the launch of a Clinical Proteomic Tumor Analysis Consortium in August 2011. CPTAC is a comprehensive and coordinated effort to accelerate the understanding of the molecular basis of cancer through the application of robust, quantitative, proteomic technologies and workflows. The overarching goal of CPTAC is to improve our ability to diagnose, treat and prevent cancer. To achieve this goal in a scientifically rigorous manner, the NCI launched CPTAC to systematically identify proteins that derive from alterations in cancer genomes and related biological processes, and provide this data with accompanying assays and protocols to the public.

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Cancer Hallmark Categories

Sustaining proliferative signaling

ErbB Signaling Pathway (Homo sapiens)

ErbB Signaling Pathway
ErbB Signaling Pathway
Evading growth suppressors

TGF-beta Receptor Signaling (Homo sapiens)

TGF-beta Receptor Signaling
TGF-beta Receptor Signaling
Activating invasion and metastasis

H19 action Rb-E2F1 signaling and CDK-Beta-catenin activity (Homo sapiens)

H19 action Rb-E2F1 signaling and CDK-Beta-catenin activity
H19 action Rb-E2F1 signaling and CDK-Beta-catenin activity
Enabling replicative immortality

Wnt Signaling Pathway (Homo sapiens)

Wnt Signaling Pathway
Wnt Signaling Pathway
Inducing angiogenesis

Hedgehog Signaling Pathway (Homo sapiens)

Hedgehog Signaling Pathway
Hedgehog Signaling Pathway
Resisting cell death

Apoptosis (Homo sapiens)

Apoptosis
Apoptosis
Deregulating cellular energetics

Hereditary leiomyomatosis and renal cell carcinoma pathway (Homo sapiens)

Hereditary leiomyomatosis and renal cell carcinoma pathway
Hereditary leiomyomatosis and renal cell carcinoma pathway
Genome instability and mutation

DNA IR-damage and cellular response via ATR (Homo sapiens)

DNA IR-damage and cellular response via ATR
DNA IR-damage and cellular response via ATR
Tumor promoting inflammation

Cytokines and Inflammatory Response (Homo sapiens)

Cytokines and Inflammatory Response
Cytokines and Inflammatory Response
Avoiding immune destruction

Type II interferon signaling (IFNG) (Homo sapiens)

Type II interferon signaling (IFNG)
Type II interferon signaling (IFNG)
Therapeutics

Fluoropyrimidine Activity (Homo sapiens)

Fluoropyrimidine Activity
Fluoropyrimidine Activity

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Featured Pathways

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Pathway Curation

On this page you see rotating displays of hallmark and featured pathways. Where did these pathways come from? They came from people like you! The CPTAC set of pathways can be edited, fixed and added to using the pathway drawing and annotation tools here at WikiPathways.

Getting Started

Resources

Curation projects

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Useful Links

Personal tools