Portal:CPTAC

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CPTAC Pathways

Welcome to the CPTAC Pathway Portal

This portal highlights pathway content relevant to the Clinical Proteomic Tumor Analysis Consortium (CPTAC).

The National Cancer Institute, part of the National Institutes of Health, announced the launch of a Clinical Proteomic Tumor Analysis Consortium in August 2011. CPTAC is a comprehensive and coordinated effort to accelerate the understanding of the molecular basis of cancer through the application of robust, quantitative, proteomic technologies and workflows. The overarching goal of CPTAC is to improve our ability to diagnose, treat and prevent cancer. To achieve this goal in a scientifically rigorous manner, the NCI launched CPTAC to systematically identify proteins that derive from alterations in cancer genomes and related biological processes, and provide this data with accompanying assays and protocols to the public.

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Cancer Hallmark Categories

Sustaining proliferative signaling

Ras Signaling (Homo sapiens)

Ras Signaling
Ras Signaling
Evading growth suppressors

Cell Cycle (Homo sapiens)

Cell Cycle
Cell Cycle
Activating invasion and metastasis

TGF-B Signaling in Thyroid Cells for Epithelial-Mesenchymal Transition (Homo sapiens)

TGF-B Signaling in Thyroid Cells for Epithelial-Mesenchymal Transition
TGF-B Signaling in Thyroid Cells for Epithelial-Mesenchymal Transition
Enabling replicative immortality

Wnt Signaling Pathway (Homo sapiens)

Wnt Signaling Pathway
Wnt Signaling Pathway
Inducing angiogenesis

PDGF Pathway (Homo sapiens)

PDGF Pathway
PDGF Pathway
Resisting cell death

miRNA regulation of p53 pathway in prostate cancer (Homo sapiens)

miRNA regulation of p53 pathway in prostate cancer
miRNA regulation of p53 pathway in prostate cancer
Deregulating cellular energetics

Type 2 papillary renal cell carcinoma (Homo sapiens)

Type 2 papillary renal cell carcinoma
Type 2 papillary renal cell carcinoma
Genome instability and mutation

ATM Signaling Network in Development and Disease (Homo sapiens)

ATM Signaling Network in Development and Disease
ATM Signaling Network in Development and Disease
Tumor promoting inflammation

Chemokine signaling pathway (Homo sapiens)

Chemokine signaling pathway
Chemokine signaling pathway
Avoiding immune destruction

Interferon type I signaling pathways (Homo sapiens)

Interferon type I signaling pathways
Interferon type I signaling pathways
Therapeutics

LncRNA-mediated mechanisms of therapeutic resistance (Homo sapiens)

LncRNA-mediated mechanisms of therapeutic resistance
LncRNA-mediated mechanisms of therapeutic resistance

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Featured Pathways

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Assay Portal

CPTAC also includes an Assay Portal to widely disseminate highly characterized proteomic assays to the global research community, with access to SOPs, reagents, and assay characterization/validation data

Resources

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Pathway Curation

On this page you see rotating displays of hallmark and featured pathways. Where did these pathways come from? They came from people like you! The CPTAC set of pathways can be edited, fixed and added to using the pathway drawing and annotation tools here at WikiPathways.

Getting Started

Resources

Curation projects

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Useful Links

Personal tools