Portal:CPTAC

From WikiPathways

Jump to: navigation, search

edit  

CPTAC Pathways

Welcome to the CPTAC Pathway Portal

This portal highlights pathway content relevant to the Clinical Proteomic Tumor Analysis Consortium (CPTAC).

The National Cancer Institute, part of the National Institutes of Health, announced the launch of a Clinical Proteomic Tumor Analysis Consortium in August 2011. CPTAC is a comprehensive and coordinated effort to accelerate the understanding of the molecular basis of cancer through the application of robust, quantitative, proteomic technologies and workflows. The overarching goal of CPTAC is to improve our ability to diagnose, treat and prevent cancer. To achieve this goal in a scientifically rigorous manner, the NCI launched CPTAC to systematically identify proteins that derive from alterations in cancer genomes and related biological processes, and provide this data with accompanying assays and protocols to the public.

The pathways included in this portal have been organized into classic cancer hallmark categories, based on the different biological capabilities acquired during the multistep development of human tumors. To read more, see Hallmarks of cancer: the next generation, Hanahan and Weinberg, Cell 2011.

edit  

Cancer Hallmark Categories

Sustaining proliferative signaling

EPO Receptor Signaling (Homo sapiens)

EPO Receptor Signaling
EPO Receptor Signaling
Evading growth suppressors

G1 to S cell cycle control (Homo sapiens)

G1 to S cell cycle control
G1 to S cell cycle control
Activating invasion and metastasis

Integrin-mediated Cell Adhesion (Homo sapiens)

Integrin-mediated Cell Adhesion
Integrin-mediated Cell Adhesion
Enabling replicative immortality

Wnt/beta-catenin Signaling Pathway in Leukemia (Homo sapiens)

Wnt/beta-catenin Signaling Pathway in Leukemia
Wnt/beta-catenin Signaling Pathway in Leukemia
Inducing angiogenesis

PDGF Pathway (Homo sapiens)

PDGF Pathway
PDGF Pathway
Resisting cell death

PI3K-AKT-mTOR signaling pathway and therapeutic opportunities (Homo sapiens)

PI3K-AKT-mTOR signaling pathway and therapeutic opportunities
PI3K-AKT-mTOR signaling pathway and therapeutic opportunities
Deregulating cellular energetics

Metabolic reprogramming in colon cancer (Homo sapiens)

Metabolic reprogramming in colon cancer
Metabolic reprogramming in colon cancer
Genome instability and mutation

DNA Mismatch Repair (Homo sapiens)

DNA Mismatch Repair
DNA Mismatch Repair
Tumor promoting inflammation

Cytokines and Inflammatory Response (Homo sapiens)

Cytokines and Inflammatory Response
Cytokines and Inflammatory Response
Avoiding immune destruction

Interferon type I signaling pathways (Homo sapiens)

Interferon type I signaling pathways
Interferon type I signaling pathways
Therapeutics

Irinotecan Pathway (Homo sapiens)

Irinotecan Pathway
Irinotecan Pathway

edit  

Featured Pathways

edit  

Assay Portal

CPTAC also includes an Assay Portal to widely disseminate highly characterized proteomic assays to the global research community, with access to SOPs, reagents, and assay characterization/validation data

Resources

Learn how they incorpated WikiPathways images with custom links on their site.

edit  

Pathway Curation

On this page you see rotating displays of hallmark and featured pathways. Where did these pathways come from? They came from people like you! The CPTAC set of pathways can be edited, fixed and added to using the pathway drawing and annotation tools here at WikiPathways.

Getting Started

Resources

Curation projects

edit  

Useful Links

Personal tools