Portal:CPTAC

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CPTAC Pathways

Welcome to the CPTAC Pathway Portal

This portal highlights pathway content relevant to the Clinical Proteomic Tumor Analysis Consortium (CPTAC).

The National Cancer Institute, part of the National Institutes of Health, announced the launch of a Clinical Proteomic Tumor Analysis Consortium in August 2011. CPTAC is a comprehensive and coordinated effort to accelerate the understanding of the molecular basis of cancer through the application of robust, quantitative, proteomic technologies and workflows. The overarching goal of CPTAC is to improve our ability to diagnose, treat and prevent cancer. To achieve this goal in a scientifically rigorous manner, the NCI launched CPTAC to systematically identify proteins that derive from alterations in cancer genomes and related biological processes, and provide this data with accompanying assays and protocols to the public.

The pathways included in this portal have been organized into classic cancer hallmark categories, based on the different biological capabilities acquired during the multistep development of human tumors. To read more, see Hallmarks of cancer: the next generation, Hanahan and Weinberg, Cell 2011.

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Cancer Hallmark Categories

Sustaining proliferative signaling

MET in type 1 papillary renal cell carcinoma (Homo sapiens)

MET in type 1 papillary renal cell carcinoma
MET in type 1 papillary renal cell carcinoma
Evading growth suppressors

Tumor suppressor activity of SMARCB1 (Homo sapiens)

Tumor suppressor activity of SMARCB1
Tumor suppressor activity of SMARCB1
Activating invasion and metastasis

H19 action Rb-E2F1 signaling and CDK-Beta-catenin activity (Homo sapiens)

H19 action Rb-E2F1 signaling and CDK-Beta-catenin activity
H19 action Rb-E2F1 signaling and CDK-Beta-catenin activity
Enabling replicative immortality

Wnt Signaling Pathway (Homo sapiens)

Wnt Signaling Pathway
Wnt Signaling Pathway
Inducing angiogenesis

Angiogenesis (Homo sapiens)

Angiogenesis
Angiogenesis
Resisting cell death

miRNA regulation of p53 pathway in prostate cancer (Homo sapiens)

miRNA regulation of p53 pathway in prostate cancer
miRNA regulation of p53 pathway in prostate cancer
Deregulating cellular energetics

Type 2 papillary renal cell carcinoma (Homo sapiens)

Type 2 papillary renal cell carcinoma
Type 2 papillary renal cell carcinoma
Genome instability and mutation

Methylation Pathways (Homo sapiens)

Methylation Pathways
Methylation Pathways
Tumor promoting inflammation

IL-6 signaling pathway (Homo sapiens)

IL-6 signaling pathway
IL-6 signaling pathway
Avoiding immune destruction

Interferon type I signaling pathways (Homo sapiens)

Interferon type I signaling pathways
Interferon type I signaling pathways
Therapeutics

Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells (Homo sapiens)

Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells
Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells

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Featured Pathways

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Assay Portal

CPTAC also includes an Assay Portal to widely disseminate highly characterized proteomic assays to the global research community, with access to SOPs, reagents, and assay characterization/validation data

Resources

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Pathway Curation

On this page you see rotating displays of hallmark and featured pathways. Where did these pathways come from? They came from people like you! The CPTAC set of pathways can be edited, fixed and added to using the pathway drawing and annotation tools here at WikiPathways.

Getting Started

Resources

Curation projects

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Useful Links

Personal tools