Pathway Talk:WP4853

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Reaction products should be anchored in one place (1)

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A reaction producing linoleic acid has products coming out from two different anchor points. For better interpretation, products should be anchored in a single point.

I now added two anchors - one for the outcoming products and one for the enzyme. If preferred, I can also connect the enzyme to the same anchor. What do you think?

Usually there are three anchor points, one of reactants, one for modifiers, one for products. The way it is done is OK now.

Pathway is very simplified (1)

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Based on figure from the paper cited, which in turn is based on

This is very simplified- for instance linoleoyl CoA desaturase doesn't work on linolenic acid, but on linoleoylCoA

Pathway details arachidonic acid synthesis in more detail, though not with bishomo LA as an on-pathway metabolite to arachidonic acid.

Hi, we can extend it the make it more accurate in any way we like. The pathway figure is a starting point.

I have some questions after looking at the original virus-related paper:

1) The paper Figure 5 seems to start from the virus itself and that crossing the membrane and interacting with cPLA2. after crossing through the glycerophospholipids bilayer. In this pathway, is seems to start with the glycerophospholipids themselves. Is that correct?

2) I think cPLA2 produces multiple fatty acids: palmitic acid, oleic acid, and linoleic acid are the relevant ones here. They all come from the ellipsoid thing that is labeled as "fatty acids" (note we could do the same using the ChEBI term). So palmitic acid oleic acid are not side-products from the linoleic acid production I think. The current drawing suggests they are.

3) The part on the left hand of the figure that mentions PAF C-16 and LPCAT is missing. While PAF C-16 actually is affected in the original study. I am not even sure what these are. But it might be relevant to add them to be able to study virus interactions?

4) The original paper actually shows what the virus infection does with the metabolites, using red "up" arrows. I think it would be nice to show the virus effects somehow without interfering with use for analysis. I originally suggested to use the same red arrows, but that actually would interfere with use for data analysis. In the end, we should probably just have a generic pathway and discuss how it was used in the description. I am also going to suggest a title change. Please revert if you do not agree.

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