Prostaglandin Synthesis and Regulation (Homo sapiens)

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(Modified description)
Current revision (12:07, 16 August 2019) (view source)
(HMDB identifier normalization)
 
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This pathway is part the [https://assays.cancer.gov/available_assays?wp_id=WP98 CPTAC Assay Portal].</Comment>
This pathway is part the [https://assays.cancer.gov/available_assays?wp_id=WP98 CPTAC Assay Portal].</Comment>
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   <Comment Source="GenMAPP remarks"></Comment>
   <Comment Source="WikiPathways-category">Metabolic Process</Comment>
   <Comment Source="WikiPathways-category">Metabolic Process</Comment>
   <BiopaxRef>ca2</BiopaxRef>
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     <Comment Source="GenMAPP remarks">PMID: 12962548 relationship with Annexin 2</Comment>
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      <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
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      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">MITF is necessary for generation of prostaglandin D2 in mouse mast cells.</bp:TITLE>
 +
      <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">J Biol Chem</bp:SOURCE>
 +
      <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2004</bp:YEAR>
 +
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Morii E</bp:AUTHORS>
 +
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Oboki K</bp:AUTHORS>
     </bp:PublicationXref>
     </bp:PublicationXref>
     <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="d4b">
     <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="d4b">
Line 849: Line 927:
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Borst P</bp:AUTHORS>
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Borst P</bp:AUTHORS>
     </bp:PublicationXref>
     </bp:PublicationXref>
-
   
 
-
    <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="b22">
 
-
      <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">17277314</bp:ID>
 
-
      <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
 
-
      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">SOX9 regulates prostaglandin D synthase gene transcription in vivo to ensure testis development.</bp:TITLE>
 
-
      <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">J Biol Chem</bp:SOURCE>
 
-
      <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2007</bp:YEAR>
 
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Wilhelm D</bp:AUTHORS>
 
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Hiramatsu R</bp:AUTHORS>
 
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Mizusaki H</bp:AUTHORS>
 
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Widjaja L</bp:AUTHORS>
 
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Combes AN</bp:AUTHORS>
 
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Kanai Y</bp:AUTHORS>
 
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Koopman P</bp:AUTHORS>
 
-
    </bp:PublicationXref>
 
-
    <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="f09">
 
-
      <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">11087758</bp:ID>
 
-
      <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
 
-
      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">FPRP, a major, highly stoichiometric, highly specific CD81- and CD9-associated protein.</bp:TITLE>
 
-
      <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">J Biol Chem</bp:SOURCE>
 
-
      <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2001</bp:YEAR>
 
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Stipp CS</bp:AUTHORS>
 
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Orlicky D</bp:AUTHORS>
 
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Hemler ME</bp:AUTHORS>
 
-
    </bp:PublicationXref>
 
-
    <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#">
 
-
      <bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">classic metabolic pathway</bp:TERM>
 
-
      <bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PW:0000002</bp:ID>
 
-
      <bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Pathway Ontology</bp:Ontology>
 
-
    </bp:openControlledVocabulary>
 
     <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="b0d">
     <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="b0d">
       <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">23568971</bp:ID>
       <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">23568971</bp:ID>
Line 890: Line 938:
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Kurzynska A</bp:AUTHORS>
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Kurzynska A</bp:AUTHORS>
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Wasielak M</bp:AUTHORS>
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Wasielak M</bp:AUTHORS>
-
    </bp:PublicationXref>
 
-
    <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#">
 
-
      <bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">prostaglandin metabolic pathway</bp:TERM>
 
-
      <bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PW:0000156</bp:ID>
 
-
      <bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Pathway Ontology</bp:Ontology>
 
-
    </bp:openControlledVocabulary>
 
-
    <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="d26">
 
-
      <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">15375155</bp:ID>
 
-
      <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
 
-
      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">MITF is necessary for generation of prostaglandin D2 in mouse mast cells.</bp:TITLE>
 
-
      <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">J Biol Chem</bp:SOURCE>
 
-
      <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2004</bp:YEAR>
 
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Morii E</bp:AUTHORS>
 
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Oboki K</bp:AUTHORS>
 
-
    </bp:PublicationXref>
 
-
    <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="b10">
 
-
      <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">18508192</bp:ID>
 
-
      <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
 
-
      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">AKR1C2 and AKR1C3 mediated prostaglandin D2 metabolism augments the PI3K/Akt proliferative signaling pathway in human prostate cancer cells.</bp:TITLE>
 
-
      <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Mol Cell Endocrinol</bp:SOURCE>
 
-
      <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2008</bp:YEAR>
 
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Wang S</bp:AUTHORS>
 
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Yang Q</bp:AUTHORS>
 
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Fung KM</bp:AUTHORS>
 
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Lin HK</bp:AUTHORS>
 
-
    </bp:PublicationXref>
 
-
    <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="e51">
 
-
      <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">20943776</bp:ID>
 
-
      <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
 
-
      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">The human aldose reductase AKR1B1 qualifies as the primary prostaglandin F synthase in the endometrium.</bp:TITLE>
 
-
      <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">J Clin Endocrinol Metab</bp:SOURCE>
 
-
      <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2011</bp:YEAR>
 
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Bresson E</bp:AUTHORS>
 
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Boucher-Kovalik S</bp:AUTHORS>
 
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Chapdelaine P</bp:AUTHORS>
 
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Madore E</bp:AUTHORS>
 
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Harvey N</bp:AUTHORS>
 
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Laberge PY</bp:AUTHORS>
 
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Leboeuf M</bp:AUTHORS>
 
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Fortier MA</bp:AUTHORS>
 
     </bp:PublicationXref>
     </bp:PublicationXref>
     <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="ca2">
     <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="ca2">
Line 941: Line 949:
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Muglia LJ</bp:AUTHORS>
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Muglia LJ</bp:AUTHORS>
     </bp:PublicationXref>
     </bp:PublicationXref>
-
     <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="a50">
+
     <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#">
-
      <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">9792917</bp:ID>
+
      <bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">prostaglandin biosynthetic pathway</bp:TERM>
-
       <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
+
       <bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PW:0001532</bp:ID>
-
      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Identification of a principal mRNA species for human 3alpha-hydroxysteroid dehydrogenase isoform (AKR1C3) that exhibits high prostaglandin D2 11-ketoreductase activity.</bp:TITLE>
+
       <bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Pathway Ontology</bp:Ontology>
-
       <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">J Biochem</bp:SOURCE>
+
    </bp:openControlledVocabulary>
-
      <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">1998</bp:YEAR>
+
    <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#">
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Matsuura K</bp:AUTHORS>
+
       <bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">classic metabolic pathway</bp:TERM>
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Shiraishi H</bp:AUTHORS>
+
       <bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PW:0000002</bp:ID>
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Hara A</bp:AUTHORS>
+
       <bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Pathway Ontology</bp:Ontology>
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Sato K</bp:AUTHORS>
+
     </bp:openControlledVocabulary>
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Deyashiki Y</bp:AUTHORS>
+
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Ninomiya M</bp:AUTHORS>
+
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Sakai S</bp:AUTHORS>
+
-
     </bp:PublicationXref>
+
     <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="a9d">
     <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="a9d">
       <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">22014308</bp:ID>
       <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">22014308</bp:ID>
Line 978: Line 982:
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Min KS</bp:AUTHORS>
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Min KS</bp:AUTHORS>
     </bp:PublicationXref>
     </bp:PublicationXref>
-
   <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#"><bp:TERM>prostaglandin biosynthetic pathway</bp:TERM><bp:ID>PW:0001532</bp:ID><bp:Ontology>Pathway Ontology</bp:Ontology></bp:openControlledVocabulary></Biopax>
+
   </Biopax>
</Pathway>
</Pathway>

Current revision

Error rendering pathway page

This revision of the pathway probably contains invalid GPML code. If this happens to the most recent revision, try reverting the pathway using the pathway history displayed below or contact the site administrators (see WikiPathways:About) to resolve this problem.

Pathway history

View all...
CompareRevisionActionTimeUserComment
106181view12:07, 16 August 2019MaintBotHMDB identifier normalization
105794view22:44, 15 August 2019KhanspersModified description
102309view21:07, 17 December 2018KhanspersModified description
102308view21:05, 17 December 2018Khanspersremoved GenMAPP comment
98180view10:11, 2 August 2018EgonwFixed a data source for a KEGG Compound.
96263view19:43, 2 March 2018EgonwFixed the data source to match the ID.
95961view12:20, 9 February 2018DeSlOntology Term : 'PW:0000002' removed !
95960view12:20, 9 February 2018DeSlOntology Term : 'prostaglandin biosynthetic pathway' added !
95959view12:19, 9 February 2018DeSlConnected unocnnected lines.
95926view07:48, 6 February 2018EgonwFixed the data source.
95925view19:39, 5 February 2018VjlynchAdded PTGFRN
95924view19:10, 5 February 2018VjlynchAdded genes involved in prostaglandin synthesis and interconversion
95921view18:01, 5 February 2018Vjlynch
95918view22:27, 4 February 2018Vjlynch
95917view18:41, 4 February 2018VjlynchUpdated genes that regualte PG synthase expression and PG export
88906view08:47, 17 August 2016MirellaKalafatiOntology Term : 'classic metabolic pathway' added !
86077view09:43, 29 June 2016MirellaKalafatiOntology Term : 'PW:0000002' removed !
86076view09:43, 29 June 2016MirellaKalafatiOntology Term : 'classic metabolic pathway' added !
86075view09:41, 29 June 2016MirellaKalafatiOntology Term : 'classic metabolic pathway' added !
85088view23:07, 12 April 2016EgonwAdded a few metabolite identifiers.
72088view21:23, 24 October 2013Mkutmonadded datasource for "Gq signaling pathway"
68986view17:43, 8 July 2013MaintBotUpdated to 2013 gpml schema
45273view18:52, 7 October 2011KhanspersModified description
45272view18:51, 7 October 2011KhanspersModified description
45268view18:48, 7 October 2011KhanspersOntology Term : 'prostaglandin metabolic pathway' added !
41161view23:41, 1 March 2011MaintBotRemoved redundant pathway information and comments
38857view18:08, 24 September 2010Khanspers
38769view23:41, 23 September 2010KhanspersChanged graphic and linked to pathway
37348view17:54, 28 May 2010KhanspersLit ref
34440view18:17, 10 December 2009MaintBotAutomatic update of empty xrefs
33624view10:03, 1 December 2009MaintBotRemoved group label
20887view11:30, 14 November 2008MaintBot[[Pathway:Homo sapiens:Prostaglandin synthesis regulation]] moved to [[Pathway:WP98]]: Moved to stable identifier
15106view23:38, 25 May 2008AlexanderPicotweak
15104view23:34, 25 May 2008AlexanderPicotweak
15101view23:30, 25 May 2008AlexanderPicotweak
15099view23:28, 25 May 2008AlexanderPicotweak
15097view23:24, 25 May 2008AlexanderPicoconnected loose ends
15034view06:20, 25 May 2008Nsalomonismoved pathway
15032view06:17, 25 May 2008Nsalomonisfurther added metabolite IDs and integrated aliased objects
15030view06:13, 25 May 2008NsalomonisPeriodical save, work in progress
15028view06:02, 25 May 2008NsalomonisPeriodical save, work in progress
15026view05:52, 25 May 2008NsalomonisPeriodical save, work in progress
15024view05:42, 25 May 2008NsalomonisPeriodical save, work in progress
15022view05:27, 25 May 2008Nsalomonisadded additional metabolite data and clarified interactions
14737view22:19, 23 May 2008KhanspersAdded connectors
14734view22:13, 23 May 2008KhanspersPeriodical save, work in progress
14732view22:03, 23 May 2008KhanspersPeriodical save, work in progress
13108view11:16, 17 May 2008MaintBotautomated metabolite conversion
8342view13:46, 7 January 2008MaintBot[[Pathway:Human:Prostaglandin synthesis regulation]] moved to [[Pathway:Homo sapiens:Prostaglandin synthesis regulation]]: Renaming species
7789view16:17, 18 December 2007MaintBotfixed category names

Error details

exception 'Exception' with message 'Unable to convert to /var/www/wikipathways/images/d/dc/WP98_prev.svg:
<BR>Status:1
<BR>Message:Exception in thread "main" java.lang.NullPointerException
	at org.pathvisio.core.Engine.getPathwayImporters(Unknown Source)
	at org.pathvisio.core.Engine.importPathway(Unknown Source)
	at org.pathvisio.core.util.Converter.main(Unknown Source)

<BR>Command:java -Xmx1024M -jar /var/www/wikipathways/wpi/bin/pathvisio_core.jar "/var/www/wikipathways" "/var/www/wikipathways/images/d/dc/WP98_prev.svg" 2>&1<BR>' in /var/www/wikipathways/wpi/extensions/Pathways/Pathway.php:1255
Stack trace:
#0 /var/www/wikipathways/wpi/extensions/Pathways/Pathway.php(1227): Pathway::convertWithPathVisio(false, '/var/www/wikipa...')
#1 /var/www/wikipathways/wpi/extensions/Pathways/Pathway.php(1137): Pathway->saveConvertedByPathVisioCache('svg')
#2 /var/www/wikipathways/wpi/extensions/Pathways/PathwayPage.php(21): Pathway->updateCache('svg')
#3 [internal function]: renderPathwayPage(Object(Parser), '<?xml version="...', Object(StripState))
#4 /var/www/wikipathways/includes/Hooks.php(125): call_user_func_array('renderPathwayPa...', Array)
#5 /var/www/wikipathways/includes/parser/Parser.php(318): wfRunHooks('ParserBeforeStr...', Array)
#6 /var/www/wikipathways/includes/OutputPage.php(405): Parser->parse('<?xml version="...', Object(Title), Object(ParserOptions), true, true, 106181)
#7 /var/www/wikipathways/includes/OutputPage.php(391): OutputPage->addWikiTextTitle('<?xml version="...', Object(Title), true, true)
#8 /var/www/wikipathways/includes/OutputPage.php(500): OutputPage->addWikiTextTitleTidy('<?xml version="...', Object(Title), true)
#9 /var/www/wikipathways/includes/DifferenceEngine.php(313): OutputPage->addWikiTextTidy('<?xml version="...')
#10 /var/www/wikipathways/includes/DifferenceEngine.php(271): DifferenceEngine->renderNewRevision()
#11 /var/www/wikipathways/includes/Article.php(729): DifferenceEngine->showDiffPage(false)
#12 /var/www/wikipathways/includes/Wiki.php(437): Article->view()
#13 /var/www/wikipathways/includes/Wiki.php(59): MediaWiki->performAction(Object(OutputPage), Object(Article), Object(Title), Object(User), Object(WebRequest))
#14 /var/www/wikipathways/index.php(93): MediaWiki->initialize(Object(Title), Object(Article), Object(OutputPage), Object(User), Object(WebRequest))
#15 {main}
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