Complement Activation, Classical Pathway (Bos taurus)

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Proteolytic CleavageCytoplasmaggregated IgG,IgM-antigen complex,polyanions, RNA, DNAlipopolysaccharidesPrevents Complement Attackantigen/antibodycomplexComplexFormationIonsC1 complexMembraneattack complexPlasmaMembraneC4AC1RC4BC1SMASP1C6C9C8AC5C1QCC3C1QAC2C8BH2OC1QBC7CD55


Description

No description

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP545(r21826) with a 82% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

  1. Brook E, Herbert AP, Jenkins HT, Soares DC, Barlow PN; ''Opportunities for new therapies based on the natural regulators of complement activation.''; Ann N Y Acad Sci, 2005 PubMed Europe PMC

History

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CompareRevisionActionTimeUserComment
105970view11:50, 16 August 2019MaintBotHMDB identifier normalization
89917view13:31, 6 October 2016MkutmonOntology Term : 'immune response pathway' added !
89916view13:31, 6 October 2016MkutmonOntology Term : 'classical complement pathway' added !
89915view13:31, 6 October 2016MkutmonOntology Term : 'innate immune response pathway' added !
89914view13:30, 6 October 2016MkutmonModified description
80673view15:21, 30 June 2015Mkutmonhomology conversion
63463view17:19, 10 May 2013MaintBotUpdated to 2013 gpml schema
40598view19:34, 1 March 2011MaintBotRemoved redundant pathway information and comments
33835view00:30, 9 December 2009MaintBotAutomatic update of empty xrefs
33622view10:02, 1 December 2009MaintBotRemoved group label
31636view22:24, 13 August 2009MaintBotFixed text labels
30546view21:58, 29 July 2009MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
C1QAGeneProduct534961 (Entrez Gene) update: C1QA HUMAN
C1QBGeneProduct617435 (Entrez Gene)
C1QCGeneProduct509968 (Entrez Gene) update C1QC HUMAN
C1RGeneProduct511581 (Entrez Gene)
C1SGeneProduct767827 (Entrez Gene)
C2GeneProduct515440 (Entrez Gene)
C3GeneProduct280677 (Entrez Gene)
C4AGeneProduct280678 (Entrez Gene)
C4BGeneProduct
C5GeneProduct512045 (Entrez Gene)
C6GeneProduct507749 (Entrez Gene)
C7GeneProduct507339 (Entrez Gene)
C8AGeneProduct527391 (Entrez Gene)
C8BGeneProduct513217 (Entrez Gene)
C9GeneProduct526766 (Entrez Gene)
CD55GeneProduct518609 (Entrez Gene)
H2OMetaboliteHMDB02111 (HMDB)
MASP1GeneProduct522347 (Entrez Gene)

Annotated Interactions

No annotated interactions
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