IL-2 Signaling Pathway (Bos taurus)

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STAT5BSTAT3STAT1MAPK1PSTAT1AKT1Pgene expressionCYNUNUAKT dependentIL-2 Signaling PathwayCYmediated gene expressionNURas-MAPK cascadeCYCYNUCBLGAB2PMAP2K2PSHC1PFYNPIL2CRKLLCKSTAT5BPIL2RGPCCND2MYCFOSRPS6IL2RABCL2JUNIL2RASTAT1PMAPTSOS1RAF1PMAP2K1PIL2RBPSTAT3PSTAT1PCISHFOXO3STAT1PGRB2JAK3PMAPK3PSTAT3PTK2BPPTPN11PRPS6KB1RPS6KB2PPJAK1PSTAT5APSYKPNMISTAT5ASTAT5APSOCS3PIK3R1PSTAT3STAT3PProteinProtein - protein dissociationInhibitionAuto catalysisTransportPositive regulation of gene expressionLeads to through unknown mechanismNegative regulation of gene expressionTranslocation UbiquitinationDeubiquitinationSumoylationInduced catalysisProtein-protein interactionAcetylationDephosphorylationLEGENDPhosphorylationDeacetylationGolgi apparatusEndosomeNucleusMitochondrionDesumoylationMethylationDemethylationPalmitoylationCytoplasmECPlasma membraneMTEndoplasmic reticulumCYPMGONUExtracellularERENProteolytic cleavageReceptorProteinmRNALigandEnzyme complexHRAS


Description

IL-2 is a multifunctional cytokine with pleiotropic effects on several cells of the immune system. IL-2 was originally discovered as a T cell growth factor, but it was also found to have actions related to B cell proliferation, and cytolytic activity of natural killer cells. IL-2 also activates lymphokine activated killer cells. In contrast to its proliferative effects, IL-2 also has potent activity in a process known as activation-induced cell death. More recently, IL-2 was shown to promote tolerance through its effects on regulatory T cell development. IL-2 clinically has anti-cancer effects as well as utility in supporting T cell numbers in HIV/AIDS. There are three classes of IL-2 receptors, binding IL-2 with low, intermediate, or high-affinity. The low affinity receptor (IL-2Rα alone) is not functional; signaling by IL-2 involves either the high affinity hetero-trimeric receptor containing IL-2Rα, IL-2Rβ and the common cytokine receptor gamma chain (originally named IL-2Rγ and now generally denoted as γc) or the intermediate affinity heterodimeric receptor composed of IL-2Rβ and γc. IL-2 stimulation induces the activation of the Janus family tyrosine kinases JAK1 and JAK3, which associate with IL-2Rβ and γc, respectively. These kinases in turn phosphorylate IL-2Rβ and induce tyrosine phosphorylation of STATs (signal transducers and activators of transcription) and various other downstream targets. The downstream signaling pathways activated by IL-2 also involves mitogen-activated protein kinase and phosphoinositide 3-kinase signaling modules, leading to both mitogenic and anti-apoptotic signals. Please access this pathway at NetSlim database. NetPath is a collaborative project between PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and the Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the NetPath website until the pathway is published.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP49(78543) with a 98.0% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

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History

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CompareRevisionActionTimeUserComment
89827view12:04, 6 October 2016MkutmonModified description
80912view15:31, 30 June 2015Mkutmonhomology conversion
67373view10:43, 26 June 2013Christine ChichesterOntology Term : 'interleukin-2 signaling pathway' added !
63312view21:01, 9 May 2013MaintBotupdating gpml
40493view19:28, 1 March 2011MaintBotRemoved redundant pathway information and comments
35784view06:21, 13 February 2010MaintBotAdded description
33737view23:54, 8 December 2009MaintBotAutomatic update of empty xrefs
31632view22:22, 13 August 2009MaintBotFixed text labels
30542view21:56, 29 July 2009MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
AKT1ProteinENSBTAG00000017636 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:207
BCL2RnaENSBTAG00000019302 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:596
CBLProteinENSBTAG00000006817 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:867
CCND2RnaENSBTAG00000016649 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:894
CISHProteinENSBTAG00000022622 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1154
CRKLProteinENSBTAG00000045548 (Ensembl)
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1399
FOSRnaENSBTAG00000004322 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2353
FOXO3ProteinENSBTAG00000011234 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2309
FYNProteinENSBTAG00000011851 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2534
GAB2Protein
GRB2ProteinENSBTAG00000004736 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2885
HRASGeneProductENSBTAG00000046644 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000174775
IL2ProteinENSBTAG00000020883 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3558
IL2RAProteinENSBTAG00000020892 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000134460
IL2RBProteinENSBTAG00000016345 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3560
IL2RGProteinENSBTAG00000007626 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3561
JAK1ProteinENSBTAG00000003147 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3716
JAK3ProteinENSBTAG00000020904 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3718
JUNRnaENSBTAG00000004037 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3725
LCKProteinENSBTAG00000012695 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3932
MAP2K1ProteinENSBTAG00000033983 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5604
MAP2K2ProteinENSBTAG00000024450 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5605
MAPK1ProteinENSBTAG00000010312 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5594
MAPK3ProteinENSBTAG00000016156 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5595
MAPTProteinENSBTAG00000017512 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4137
MYCRnaENSBTAG00000008409 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4609
NMIProteinENSBTAG00000032369 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9111
PIK3R1ProteinENSBTAG00000010989 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5295
PTK2BProteinENSBTAG00000005958 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2185
PTPN11ProteinENSBTAG00000002048 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5781
RAF1ProteinENSBTAG00000045748 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5894
RPS6ProteinENSBTAG00000014449 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6194
RPS6KB1ProteinENSBTAG00000016851 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6198
RPS6KB2ProteinENSBTAG00000009175 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6199
SHC1ProteinENSBTAG00000019838 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6464
SOCS3ProteinENSBTAG00000008441 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9021
SOS1ProteinENSBTAG00000011643 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6654
STAT1ProteinENSBTAG00000007867 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6772
STAT3ProteinENSBTAG00000021523 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6774
STAT5AProteinENSBTAG00000009496 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6776
STAT5BProteinENSBTAG00000010125 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6777
SYKProteinENSBTAG00000004767 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6850

Annotated Interactions

No annotated interactions
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