IL-2 Signaling Pathway (Bos taurus)

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ActivationCY -> NUDCY -> NUCytoplasmDDEndosomePhosphorylationDeacetylationECProteolytic cleavage(Protein-protein interaction)Proteins in a complex interactionSumoylationNUMethylationCY -> NUEnzyme complexDesumoylationDPalmitolyationControlCY -> NUAccession Number: NetPath 14CYReactions through unknown mechanisms/moleculesDMTMTAcetylationDDemethylationReceptorUbiquitinationAutophosphorylationExtracellularENInhibitionPlasma membraneCY -> NUCY -> PMDGOCY -> NUTranslocationPM -> CYDNucleusDMitochondrionNUERRecruitmentLigandDGene SymbolEndoplasmic reticulumGlycosylationDGolgi apparatusMolecular associationCY -> NUNucleusPMDeubiquitinationMolecule in the pathwayDPhosphorylationCY -> NUDephosphorylationIL2STAT3PLCB1AKT1CREB1IL2RAJAK1EIF3BSTAM2GRB2MAPK3ETS2PRKCZIFNA1RAF1SHBMAP2K2SOCS3BCL2MKNK1CD53IL2LOC100139219RAF1LYNJAK2RELAPIK3CGEIF4EPIK3CDSOS1HSPCAIL2RGSTAT1PTPN11MAPKAPK2MAPK3MAPK8PIK3R1NMIPIK3R2MAPK1NR3C1IL2ITM2BCRKLJAK3CRKSTAT5AAKT1MAPK14CRKNFKB1PTK2BCBLMAPK1STAT5BYBX1TERTTERTSYKSTAT5BFOXO3AKT1ETS1SHC1KRASICAM1RELALCKCISHIL2IRS2YBX1IL2RBSTAT5AFYNPIK3CBRPS6KB1VAV1IRS1MAPK9GAB2PIK3CACHUKSTAMPTPN6SOCS1NFKB1IL2MAP2K1GNB2L1


Description

Interleukin-2 belongs to a family of cytokines, which includes IL-4, IL-7, IL-9, IL-15 and IL-21. IL-2 signals through a receptor complex consisting of IL-2 specific IL-2 receptor alpha (CD25), IL-2 receptor beta (CD122) and a common gamma chain (γc), which is shared by all members of this family of cytokines. Binding of IL-2 activates the Ras/MAPK, JAK/Stat and PI 3-kinase/Akt signaling modules. Source: NetPath http://www.netpath.org/pathways?path_id=NetPath_14

Comments

GenMAPP notes 
NetPath 14 - IL-2 Signaling Pathway

NetPath (http://www.netpath.org) is a collaborative project between PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and the Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the NetPath website until the pathway is published.

GenMAPP remarks 
http://www.netpath.org
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP49(r20779) with a 93% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

No bibliography


History

View all...
CompareRevisionActionTimeUserComment
89827view12:04, 6 October 2016MkutmonModified description
80912view15:31, 30 June 2015Mkutmonhomology conversion
67373view10:43, 26 June 2013Christine ChichesterOntology Term : 'interleukin-2 signaling pathway' added !
63312view21:01, 9 May 2013MaintBotupdating gpml
40493view19:28, 1 March 2011MaintBotRemoved redundant pathway information and comments
35784view06:21, 13 February 2010MaintBotAdded description
33737view23:54, 8 December 2009MaintBotAutomatic update of empty xrefs
31632view22:22, 13 August 2009MaintBotFixed text labels
30542view21:56, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AKT1GeneProduct280991 (Entrez Gene)
BCL2GeneProduct281020 (Entrez Gene)
CBLGeneProduct527418 (Entrez Gene)
CD53GeneProduct505040 (Entrez Gene)
CHUKGeneProduct281073 (Entrez Gene)
CISHGeneProduct616753 (Entrez Gene)
CREB1GeneProduct281713 (Entrez Gene)
CRKGeneProduct512841 (Entrez Gene)
CRKLGeneProduct
EIF3BGeneProduct789999 (Entrez Gene)
EIF4EGeneProduct281751 (Entrez Gene)
ETS1GeneProduct540313 (Entrez Gene)
ETS2GeneProduct281148 (Entrez Gene)
FOXO3GeneProduct535530 (Entrez Gene)
FYNGeneProduct527263 (Entrez Gene)
GAB2GeneProduct529346 (Entrez Gene)
GNB2L1GeneProduct327682 (Entrez Gene)
GRB2GeneProduct535298 (Entrez Gene)
HSPCAGeneProduct281832 (Entrez Gene)
ICAM1GeneProduct281839 (Entrez Gene)
IFNA1GeneProduct281843 (Entrez Gene)
IL2GeneProduct280822 (Entrez Gene)
IL2RAGeneProduct281861 (Entrez Gene)
IL2RBGeneProduct510185 (Entrez Gene)
IL2RGGeneProduct281862 (Entrez Gene)
IRS1GeneProduct538598 (Entrez Gene)
IRS2GeneProduct
ITM2BGeneProduct510575 (Entrez Gene)
JAK1GeneProduct537201 (Entrez Gene)
JAK2GeneProduct525246 (Entrez Gene)
JAK3GeneProduct
KRASGeneProduct541140 (Entrez Gene)
LCKGeneProduct508890 (Entrez Gene)
LOC100139219GeneProduct100139219 (Entrez Gene)
LYNGeneProduct534996 (Entrez Gene)
MAP2K1GeneProduct533199 (Entrez Gene)
MAP2K2GeneProduct510434 (Entrez Gene)
MAPK1GeneProduct327672 (Entrez Gene)
MAPK14GeneProduct534492 (Entrez Gene)
MAPK3GeneProduct531391 (Entrez Gene)
MAPK8GeneProduct539941 (Entrez Gene)
MAPK9GeneProduct534125 (Entrez Gene)
MAPKAPK2GeneProduct788091 (Entrez Gene)
MKNK1GeneProduct525647 (Entrez Gene)
NFKB1GeneProduct616115 (Entrez Gene)
NMIGeneProduct784981 (Entrez Gene)
NR3C1GeneProduct281946 (Entrez Gene)
PIK3CAGeneProduct282306 (Entrez Gene)
PIK3CBGeneProduct517948 (Entrez Gene)
PIK3CDGeneProduct504531 (Entrez Gene)
PIK3CGGeneProduct530001 (Entrez Gene)
PIK3R1GeneProduct282307 (Entrez Gene)
PIK3R2GeneProduct282308 (Entrez Gene)
PLCB1GeneProduct287026 (Entrez Gene)
PRKCZGeneProduct286877 (Entrez Gene)
PTK2BGeneProduct541008 (Entrez Gene)
PTPN11GeneProduct533590 (Entrez Gene)
PTPN6GeneProduct512312 (Entrez Gene)
RAF1GeneProduct521196 (Entrez Gene)
RELAGeneProduct508233 (Entrez Gene)
RPS6KB1GeneProduct404181 (Entrez Gene)
SHBGeneProduct538275 (Entrez Gene)
SHC1GeneProduct507196 (Entrez Gene)
SOCS1GeneProduct518795 (Entrez Gene)
SOCS3GeneProduct282081 (Entrez Gene)
SOS1GeneProduct537682 (Entrez Gene)
STAM2GeneProduct538505 (Entrez Gene)
STAMGeneProduct512734 (Entrez Gene)
STAT1GeneProduct510814 (Entrez Gene)
STAT3GeneProduct508541 (Entrez Gene)
STAT5AGeneProduct282375 (Entrez Gene)
STAT5BGeneProduct282376 (Entrez Gene)
SYKGeneProduct515515 (Entrez Gene)
TERTGeneProduct518884 (Entrez Gene)
VAV1GeneProduct617345 (Entrez Gene)
YBX1GeneProduct287023 (Entrez Gene)

Annotated Interactions

No annotated interactions
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