Monoamine GPCRs (Pan troglodytes)

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SerotoninReceptorsAdrenergicReceptorsGs PathwayDopamineReceptorsGq/G11 PathwayGi/Go PathwayGs PathwayHistamineReceptorsMuscarinicAcetylcholine ReceptorsAcetylcholine HTR2CHTR6CHRM2CHRM3HistamineDRD4HTR2BNorepinephrineCHRM4ADRA1DHTR5BHTR1BADRB1ADRB2DRD1HTR1AADRA1AHTR4DRD5CHRM1HTR7EpinephrineADRA1BDopamineHTR1DHTR2AMuscarineCHRM5DRD2DRD3ADRA2BHRH2HTR1FHTR5ASerotoninHRH1ADRA2AADRA2CADRB3HTR1E


G protein–coupled receptors (GPCRs) which are also known as seven-(pass)-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptor, and G protein–linked receptors (GPLR), constitute a large protein family of receptors that detect molecules outside the cell and activate internal signal transduction pathways and, ultimately, cellular responses. Coupling with G proteins, they are called seven-transmembrane receptors because they pass through the cell membrane seven times. Source: Wikipedia

Monoamine GPCRs are Rhodopsin-like GPCRs that bind to monoamine neurotransmitters. Monoamine neurotransmitters


This pathway was inferred from Homo sapiens pathway WP58(r20799) with a 72% conversion rate.

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106945view13:40, 17 September 2019MaintBotHMDB identifier normalization
98237view12:37, 14 August 2018EgonwReplace a PubChem SID with a PubChem CID.
96086view19:06, 15 February 2018KhanspersModified description
96085view19:05, 15 February 2018KhanspersModified description
74167view09:57, 2 April 2014EgonwUpdated the PubChem-substance data source.
71670view19:40, 17 October 2013MaintBotAutomated update of data sources
69259view18:37, 8 July 2013MaintBotUpdated to 2013 gpml schema
41566view01:59, 2 March 2011MaintBotRemoved redundant pathway information and comments
34294view22:03, 9 December 2009MaintBotAutomatic update of empty xrefs
33606view09:58, 1 December 2009MaintBotRemoved group label
31621view22:19, 13 August 2009MaintBotFixed text labels
30526view21:51, 29 July 2009MaintBotNew pathway

External references


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NameTypeDatabase referenceComment
ADRA1DGeneProduct469869 (Entrez Gene)
ADRA2AGeneProduct466201 (Entrez Gene)
ADRA2BGeneProduct459410 (Entrez Gene)
ADRB1GeneProduct466206 (Entrez Gene)
ADRB2GeneProduct471690 (Entrez Gene)
ADRB3GeneProduct464113 (Entrez Gene)
Acetylcholine MetaboliteHMDB0000895 (HMDB)
CHRM1GeneProduct451272 (Entrez Gene)
CHRM2GeneProduct463758 (Entrez Gene)
CHRM3GeneProduct469725 (Entrez Gene)
CHRM4GeneProduct466504 (Entrez Gene)
CHRM5GeneProduct503515 (Entrez Gene)
DRD2GeneProduct451553 (Entrez Gene)
DRD3GeneProduct470885 (Entrez Gene)
DRD4GeneProduct449578 (Entrez Gene)
DRD5GeneProduct473340 (Entrez Gene)
EpinephrineMetaboliteHMDB0000068 (HMDB)
HRH1GeneProduct470746 (Entrez Gene)
HRH2GeneProduct471750 (Entrez Gene)
HTR1AGeneProduct471533 (Entrez Gene)
HTR1BGeneProduct462833 (Entrez Gene)
HTR1DGeneProduct469219 (Entrez Gene)
HTR1EGeneProduct472064 (Entrez Gene)
HTR1FGeneProduct470863 (Entrez Gene)
HTR2AGeneProduct467355 (Entrez Gene)
HTR2BGeneProduct737647 (Entrez Gene)
HTR2CGeneProduct473740 (Entrez Gene)
HTR4GeneProduct462175 (Entrez Gene)
HTR5AGeneProduct463837 (Entrez Gene)
HTR6GeneProduct469199 (Entrez Gene)
HTR7GeneProduct466154 (Entrez Gene)
MuscarineMetabolite9308 (PubChem-compound)
NorepinephrineMetaboliteHMDB0000216 (HMDB)

Annotated Interactions

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