Matrix Metalloproteinases (Pan troglodytes)

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1Potential Inducers of Transcriptiondevelopment and normal physiology.MetalloelastaseGenes Dev 14:2123-2133CollagenasesStromelysinsEnamelysinMatrilysinInhibitorsBased on Vu & Werb (2000)GelatinasesOtherMatrix metalloproteinases: effectors ofMembrane-type MMPsTCF20MMP27MMP20BSGTNFMMP19MMP17MMP7MMP11MMP3TIMP3MMP21MMP1MMP26MMP14TIMP1MMP9MMP23AMMP23BMMP2MMP10MMP12MMP8MMP25TIMP2MMP13TIMP4MMP24MMP15MMP16MMP28


Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases; other family members are adamalysins, serralysins, and astacins. The MMPs belong to a larger family of proteases known as the metzincin superfamily.

Collectively they are capable of degrading all kinds of extracellular matrix proteins, but also can process a number of bioactive molecules. They are known to be involved in the cleavage of cell surface receptors, the release of apoptotic ligands (such as the FAS ligand), and chemokine/cytokine in/activation. MMPs are also thought to play a major role on cell behaviors such as cell proliferation, migration (adhesion/dispersion), differentiation, angiogenesis, apoptosis and host defense.

Source: Wikipedia


This pathway was inferred from Homo sapiens pathway WP129(r20953) with a 74% conversion rate.

Quality Tags

Ontology Terms



  1. Vu TH, Werb Z; ''Matrix metalloproteinases: effectors of development and normal physiology.''; Genes Dev, 2000 PubMed Europe PMC Scholia


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69314view18:43, 8 July 2013MaintBotUpdated to 2013 gpml schema
67455view11:04, 26 June 2013DdiglesOntology Term : 'cell-extracellular matrix signaling pathway' added !
41624view02:03, 2 March 2011MaintBotRemoved redundant pathway information and comments
35339view08:39, 12 February 2010ThomasModified description
35334view08:35, 12 February 2010Thomasmoved reference from comments to bibliography
34352view22:22, 9 December 2009MaintBotAutomatic update of empty xrefs
33592view09:54, 1 December 2009MaintBotRemoved group label
31613view22:15, 13 August 2009MaintBotFixed text labels
30511view21:46, 29 July 2009MaintBotNew pathway

External references


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NameTypeDatabase referenceComment
MMP10GeneProduct740658 (Entrez Gene)
MMP11GeneProduct458701 (Entrez Gene)
MMP12GeneProduct451512 (Entrez Gene)
MMP13GeneProduct451513 (Entrez Gene)
MMP1GeneProduct451510 (Entrez Gene)
MMP14GeneProduct742887 (Entrez Gene)
MMP15GeneProduct467988 (Entrez Gene)
MMP16GeneProduct736322 (Entrez Gene)
MMP17GeneProduct452375 (Entrez Gene)
MMP19GeneProduct746523 (Entrez Gene)
MMP20GeneProduct740407 (Entrez Gene)
MMP23BGeneProduct746857 (Entrez Gene)
MMP24GeneProduct469925 (Entrez Gene)
MMP2GeneProduct454094 (Entrez Gene)
MMP26GeneProduct450977 (Entrez Gene)
MMP27GeneProduct466763 (Entrez Gene)
MMP3GeneProduct451511 (Entrez Gene)
MMP7GeneProduct451509 (Entrez Gene)
MMP8GeneProduct740516 (Entrez Gene)
MMP9GeneProduct458294 (Entrez Gene)
TCF20GeneProduct458876 (Entrez Gene)
TIMP3GeneProduct458784 (Entrez Gene)
TIMP4GeneProduct460176 (Entrez Gene)
TNFGeneProduct744399 (Entrez Gene)

Annotated Interactions

No annotated interactions
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