p38 MAPK Signaling Pathway (Pan troglodytes)

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1-8DNA transcriptionStress: Osmotic shockg-radiation, Anisomycin?Cytokines Production,Apoptosis, etc.Apoptosis?FASL, InflammatoryCytokines, UV, etc.?Growth Factors, UVTrophic Factors, etc.?Right click for commentsTranslation?RPS6KA5MAP2K4MAXMEF2DSHC1MAP3K9GRB2RIPK1TRAF2TGFB2MAP3K1HRASHSPB1MAP3K5MAPKAPK5MAP2K6RASGRF1ELK1HMGN1DAXXATF2TGFBR1MAPKAPK2MAPKAPK2MKNK1MYCSTAT1CREB1CDC42TRADDPLA2G4ADDIT3MAPK14MAPK14RAC1MAP3K7


p38 MAPKs are members of the MAPK family that are activated by a variety of environmental stresses and inflammatory cytokines. Stress signals are delivered to this cascade by members of small GTPases of the Rho family (Rac, Rho, Cdc42). As with other MAPK cascades, the membrane-proximal component is a MAPKKK, typically a MEKK or a mixed lineage kinase (MLK). The MAPKKK phosphorylates and activated MKK3/5, the p38 MAPK kinase. MKK3/6 can also be activated directly by ASK1, which is stimulated by apoptotic stimuli. P38 MAK is involved in regulation of Hsp27 and MAPKAP-2 and several transcription factors including ATF2, STAT1, THE Max/Myc complex, MEF-2, ELK-1 and indirectly CREB via activation of MSK1.


GenMAPP remarks 
Converted to human by GenMAPP.org
This pathway was inferred from Homo sapiens pathway WP400(r21524) with a 80% conversion rate.

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  1. Lewis TS, Hunt JB, Aveline LD, Jonscher KR, Louie DF, Yeh JM, Nahreini TS, Resing KA, Ahn NG; ''Identification of novel MAP kinase pathway signaling targets by functional proteomics and mass spectrometry.''; Mol Cell, 2000 PubMed Europe PMC Scholia
  2. Kyriakis JM; ''Making the connection: coupling of stress-activated ERK/MAPK (extracellular-signal-regulated kinase/mitogen-activated protein kinase) core signalling modules to extracellular stimuli and biological responses.''; Biochem Soc Symp, 1999 PubMed Europe PMC Scholia
  3. Li S, Wattenberg EV; ''Cell-type-specific activation of p38 protein kinase cascades by the novel tumor promoter palytoxin.''; Toxicol Appl Pharmacol, 1999 PubMed Europe PMC Scholia
  4. Roberson MS, Zhang T, Li HL, Mulvaney JM; ''Activation of the p38 mitogen-activated protein kinase pathway by gonadotropin-releasing hormone.''; Endocrinology, 1999 PubMed Europe PMC Scholia
  5. Herlaar E, Brown Z; ''p38 MAPK signalling cascades in inflammatory disease.''; Mol Med Today, 1999 PubMed Europe PMC Scholia
  6. Ichijo H; ''From receptors to stress-activated MAP kinases.''; Oncogene, 1999 PubMed Europe PMC Scholia
  7. Wysk M, Yang DD, Lu HT, Flavell RA, Davis RJ; ''Requirement of mitogen-activated protein kinase kinase 3 (MKK3) for tumor necrosis factor-induced cytokine expression.''; Proc Natl Acad Sci U S A, 1999 PubMed Europe PMC Scholia
  8. Tibbles LA, Woodgett JR; ''The stress-activated protein kinase pathways.''; Cell Mol Life Sci, 1999 PubMed Europe PMC Scholia


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111162view09:24, 21 July 2020EgonwMade another pathway clickable
95746view13:50, 19 January 2018MkutmonHomology conversion update
95121view15:04, 16 November 2017Mkutmonadded missing homology converter comment source
71864view21:20, 18 October 2013MaintBotModified title
69264view18:38, 8 July 2013MaintBotUpdated to 2013 gpml schema
67572view11:27, 26 June 2013DdiglesOntology Term : 'p38 MAPK signaling pathway' added !
41572view02:00, 2 March 2011MaintBotRemoved redundant pathway information and comments
38248view21:26, 27 August 2010KhanspersRemoved receptor and protein complex graphics
38247view21:25, 27 August 2010Khanspers
35700view23:12, 12 February 2010KhanspersDescription and Bibliography
34300view22:05, 9 December 2009MaintBotAutomatic update of empty xrefs
33574view09:47, 1 December 2009MaintBotRemoved group label
31599view22:08, 13 August 2009MaintBotFixed text labels
30487view21:37, 29 July 2009MaintBotNew pathway

External references


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NameTypeDatabase referenceComment
CDC42GeneProduct456609 (Entrez Gene)
CREB1GeneProduct459901 (Entrez Gene)
DAXXGeneProduct462613 (Entrez Gene)
DDIT3GeneProduct452017 (Entrez Gene)
GRB2GeneProduct737245 (Entrez Gene)
HMGN1GeneProduct458552 (Entrez Gene)
HRASGeneProduct466302 (Entrez Gene)
HSPB1GeneProduct463488 (Entrez Gene)
MAP2K4GeneProduct455065 (Entrez Gene)
MAP2K6GeneProduct468310 (Entrez Gene)
MAP3K1GeneProduct471543 (Entrez Gene)
MAP3K5GeneProduct463023 (Entrez Gene)
MAP3K7GeneProduct462888 (Entrez Gene)
MAP3K9GeneProduct467498 (Entrez Gene)
MAPK14GeneProduct450161 (Entrez Gene)
MAPKAPK2GeneProduct744091 (Entrez Gene)
MAPKAPK5GeneProduct738233 (Entrez Gene)
MAXGeneProduct452972 (Entrez Gene)
MEF2DGeneProduct457396 (Entrez Gene)
MKNK1GeneProduct469189 (Entrez Gene)
MYCGeneProduct464393 (Entrez Gene)
PLA2G4AGeneProduct469617 (Entrez Gene)
RASGRF1GeneProduct453575 (Entrez Gene) PDZ domain containing guanine nucleotide exchange
RIPK1GeneProduct462397 (Entrez Gene) receptor (TNFRSF)-interacting serine-threonine kinase 1
RPS6KA5GeneProduct739162 (Entrez Gene)
SHC1GeneProduct457351 (Entrez Gene)
STAT1GeneProduct459834 (Entrez Gene)
TGFB2GeneProduct457742 (Entrez Gene)
TGFBR1GeneProduct472992 (Entrez Gene)
TRADDGeneProduct454154 (Entrez Gene)

Annotated Interactions

No annotated interactions
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