Androgen receptor signaling pathway (Pan troglodytes)

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1-7MTCYPMGlycosylationDPPalmitoylationCY->NUGOPECActivationReceptorDeSumoylationCY->NUCY->NUProteolytic CleavageNU(Protein-protein interaction)Molecular associationGene SymbolPAndrogen IndependentMitochondrionDephosphorylationCY->NUDeacetylationDemethylationEnzyme complexLigandRecruitmentEndoplasmic reticulumGolgi appparatusDNucleusENPControlInhibitionDPMolecule in the pathwayExtracellularReactions through unknown mechanisms/moleculesERSumoylationProteins in a complex interactionMethylationAcetylationDCytoplasmAndrogen IndependentDeubiquitinationAccession Number: NetPath 2; cellmap:2EndosomePhosphorylationUbiquitinationAndrogen (T/DHT)Plasma membraneTranslocationAutophosphorylationDARTGFB1I1ESR1NSD1NR5A1BRCA1AKT1TMF1RANSTUB1AESYWHAHMAPK1PXNETV5SP1TGIF1RCHY1PATZ1SMAD3KAT5MYST2SIN3APAK6HRMT1L2CCNE1RCHY1TP53RANBP9CTDP1PIAS2NR0B1CCND1PLAGL1KAT2BHSPA1AMDM2NCOA2PNRC1CDK9LOC741789HIPK3PSMC3IPNCOA3ARNRIP1CASP8ARJUNLOC464259CASP3EGFRSRYUBE3AMAPK1NCOR2RNF14NCOA1UBE2ISTAT3CDC25BCREBBPRAD54L2SLC25A4CCNHRB1CTNNB1CASP7SMAD4ESR2SPDEFFLNAARPNRC1PA2G4CDC2PTENRELARHOXF2GAPDHRB1RAF1GHRNR0B2RNF4GTF2F2FHL2CASP1HRMT1L2JUNIL6UXTPIAS1BAG1SRCRUNX2CDC37CAV1IGF1ATF2GTF2F1SENP1RAC3RASAKT1POU2F1EP300CALRNR3C1HMGB2MMP1CDK7RUNX1POU2F2HMGB1NR2C2MAP2K1IL6STESR1SVILPIAS4FLNANR3C1NCOA4APPL1ARGTF2H1PIAS3


Description

The androgen receptor is a member of the nuclear receptor family of ligand activated transcription factors. These receptors bind to steroid hormones, thyroid hormone, retinoids and vitamin D among others, dimerize and bind to DNA. Its ligands include testosterone, dehydroepiandrosterone and androstenedione. Stimulation of the receptor activates the SMAD signaling module. Source: http://www.netpath.org/pathways?path_id=NetPath_2

Comments

GenMAPP notes 
NetPath:2; cellmap:2 - Androgen Receptor Signaling Pathway. The Androgen Receptor signaling pathway was kindly reviewed by Liying Zhang and William Gerald. This cancer signaling pathway is available at Cancer Cell Map (http://cancer.cellmap.org) and NetPath (http://www.netpath.org) and is part of a collaborative project between the Computational Biology Center at Memorial Sloan-Kettering Cancer Center (http://cbio.mskcc.org), PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the Cancer Cell Map and NetPath websites until the pathway is published.
GenMAPP remarks 
http://cancer.cellmap.org; http://www.netpath.org
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP138(r20973) with a 85% conversion rate.

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Bibliography

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History

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CompareRevisionActionTimeUserComment
78369view10:19, 7 January 2015MaintBotadded missing graphIds
71674view19:41, 17 October 2013MaintBotAutomated update of data sources
69267view18:38, 8 July 2013MaintBotUpdated to 2013 gpml schema
67047view09:59, 26 June 2013Christine ChichesterOntology Term : 'androgen signaling pathway' added !
48149view18:42, 9 May 2012MaintBotUpdating from human to fix xrefs
41575view02:00, 2 March 2011MaintBotRemoved redundant pathway information and comments
35683view22:53, 12 February 2010AlexanderPico
35679view22:50, 12 February 2010AlexanderPicoadding description and refs
34303view22:06, 9 December 2009MaintBotAutomatic update of empty xrefs
31586view22:04, 13 August 2009MaintBotFixed text labels
30466view21:30, 29 July 2009MaintBotNew pathway

External references

DataNodes

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TGIF1GeneProduct455312 (Entrez Gene)
TMF1GeneProduct470844 (Entrez Gene)
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UBE2IGeneProduct749975 (Entrez Gene)
UBE3AGeneProduct453269 (Entrez Gene)
UXTGeneProduct465609 (Entrez Gene)
YWHAHGeneProduct458778 (Entrez Gene)

Annotated Interactions

No annotated interactions
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