FAS pathway and Stress induction of HSP regulation (Rattus norvegicus)

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1ProteasomeCutSelf-activationNucleus3x-P3x-PStressDNA presentationNecrosisCell SurvivalMitochondria PathwayNFK-B PathwayStress Induction of HSP regulationActivateROSExtracellularCytoplasm3x-PApoptosisInhibitionFAS PathwayApoptosomeDffaMapkapk3Rb1JunHspb1Lmnb2Casp3PhosphateMap2k4Faf1LmnaPhosphateHspb1Apaf1CeramideArhgdibCasp3Casp7Il1aDaxxDffbGlutathioneDffbMapk8PhosphateHspb1PhosphateCasp8FaddPak2Hspb1Faf1FasFaslgCasp6Hspb1PrkdcCasp9TnfParp1DaxxCasp8Hspb1Mapkapk2PhosphateHspb1Hspb1CASP10Pak1Apaf1PhosphateMap3k1actinPhosphateCflarCycsSpna2PhosphateLmnb1FAP1Ripk2Bcl2Map3k7


This pathway describes the Fas induced apoptosis and interplay with Hsp27 in response to stress. More info: BioCarta.


This pathway was inferred from Homo sapiens pathway WP314(r21341) with a 94% conversion rate.

Quality Tags

Ontology Terms



  1. Creagh EM, Sheehan D, Cotter TG; ''Heat shock proteins--modulators of apoptosis in tumour cells.''; Leukemia, 2000 PubMed Europe PMC Scholia


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109406view17:50, 16 March 2020L DupuisFixed interactions
109386view15:41, 16 March 2020L DupuisConverted interactions to graphical lines
107008view13:46, 17 September 2019MaintBotHMDB identifier normalization
71788view20:32, 17 October 2013MaintBotAutomated update of data sources
69391view18:58, 8 July 2013MaintBotUpdated to 2013 gpml schema
67225view10:23, 26 June 2013Christine ChichesterOntology Term : 'FasL mediated signaling pathway' added !
47779view05:47, 6 April 2012Khanspersupdated xref
41708view02:37, 2 March 2011MaintBotRemoved redundant pathway information and comments
38245view21:23, 27 August 2010KhanspersRemoved receptor and protein complex graphics
35564view15:04, 12 February 2010Thomasadded literature
35559view15:01, 12 February 2010ThomasModified description
34087view19:15, 9 December 2009MaintBotAutomatic update of empty xrefs
33554view09:41, 1 December 2009MaintBotRemoved group label
31581view22:02, 13 August 2009MaintBotFixed text labels
30965view00:47, 30 July 2009MaintBotConverted from Homo sapiens
20869view11:30, 14 November 2008MaintBot[[Pathway:Rattus norvegicus:Fas Pathway and Stress Induction of HSP Regulation Biocarta]] moved to [[Pathway:WP89]]: Moved to stable identifier
8020view13:46, 7 January 2008MaintBot[[Pathway:Rat:Fas Pathway and Stress Induction of HSP Regulation Biocarta]] moved to [[Pathway:Rattus norvegicus:Fas Pathway and Stress Induction of HSP Regulation Biocarta]]: Renaming species
7633view16:06, 18 December 2007MaintBotfixed category names
7221view12:41, 4 November 2007MaintBotAdded categories to GPML
6535view22:20, 22 May 2007169.230.77.174gpml file for [[Rat:Fas_Pathway_and_Stress_Induction_of_HSP_Regulation_Biocarta]]

External references


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NameTypeDatabase referenceComment
Apaf1GeneProduct78963 (Entrez Gene)
ArhgdibGeneProduct362456 (Entrez Gene) Interim Symbol: Arhgdib predicted and Name: Rho, GDP dissociation inhibitor (GDI) beta (predicted)
Bcl2GeneProduct24224 (Entrez Gene)
Casp3GeneProduct25402 (Entrez Gene)
Casp6GeneProduct83584 (Entrez Gene)
Casp7GeneProduct64026 (Entrez Gene)
Casp8GeneProduct64044 (Entrez Gene)
Casp9GeneProduct58918 (Entrez Gene)
CflarGeneProduct117279 (Entrez Gene)
CycsGeneProduct25309 (Entrez Gene)
DaxxGeneProduct140926 (Entrez Gene)
DffaGeneProduct114214 (Entrez Gene)
DffbGeneProduct84359 (Entrez Gene)
FaddGeneProduct266610 (Entrez Gene)
Faf1GeneProduct140657 (Entrez Gene)
FasGeneProduct246097 (Entrez Gene)
FaslgGeneProduct25385 (Entrez Gene)
GlutathioneMetaboliteHMDB0000125 (HMDB)
Hspb1GeneProduct24471 (Entrez Gene)
Il1aGeneProduct24493 (Entrez Gene)
JunGeneProduct24516 (Entrez Gene)
LmnaGeneProduct60374 (Entrez Gene)
Lmnb1GeneProduct116685 (Entrez Gene)
Lmnb2GeneProduct299625 (Entrez Gene)
Map2k4GeneProduct287398 (Entrez Gene)
Map3k1GeneProduct116667 (Entrez Gene)
Map3k7GeneProduct313121 (Entrez Gene)
Mapk8GeneProduct116554 (Entrez Gene)
Mapkapk2GeneProduct289014 (Entrez Gene)
Mapkapk3GeneProduct315994 (Entrez Gene)
Pak1GeneProduct29431 (Entrez Gene)
Pak2GeneProduct29432 (Entrez Gene)
Parp1GeneProduct25591 (Entrez Gene)
PhosphateMetaboliteHMDB0001429 (HMDB)
PrkdcGeneProduct360748 (Entrez Gene)
Rb1GeneProduct24708 (Entrez Gene)
Ripk2GeneProduct362491 (Entrez Gene) receptor (TNFRSF)-interacting serine-threonine kinase 2
Spna2GeneProduct64159 (Entrez Gene) Interim Symbol: Spna1 predicted and Name: spectrin alpha 1 (predicted)
TnfGeneProduct24835 (Entrez Gene)

Annotated Interactions

No annotated interactions
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