EGFR1 Signaling Pathway (Pan troglodytes)

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1PhosphorylationCYActivationPMCYPMMACYCYPMPMCYDeubiquitinationPMUbiquitinationNUNUPMNUDesumoylationDNUNUPlasma membraneReceptorCYCYMADephosphorylationGolgi apparatus(Protein-protein interaction)PMECCYPMEndoplasmic reticulumPMMAERGONUPMCYMAPMMACYPalmitoylationNUDENCYCYMADemethylationNUCYPMMolecular associationNUCYMAMASumoylationProteins in a complex interactionNUDeacetylationMTGene SymbolNUMAPMPMCYPMMACYNUCYAcetylationMAPMMAAccession Number : NetPath 4; cellmap:4GlycosylationCYENReaction through unknown mechanisms/moleculesMACYCYCYNUPMMADAutodephosphorylationMACYNUMANUInhibitionPMCYCYCYNUMANUNULigandPMEnzyme complexRecruitmentPMCYEndosomeAutophosphorylationControlMACYTranslocationCYPMCYPMMitochondrionNUMAMethylationNucleusMACYProteolytic cleavageCYENCYMACYExtracellularCYNUCytoplasmCYMolecule in the pathwayPLCG1SHC1PTPRRPAK1PITPNAPKN2MAP2K3EGFPTPN5RIPK1RALGDSMAPK8YWHABGRB14PRKCGCTNND1APPL1PLSCR1ELF3RAB5ARALBSNRPD2PEBP1CRKSIN3ASTAT1SH3KBP1RALBP1MCF2FOSRPS6KA1DOK2LOC464259CAMK2ASP1TNK2SMAD3EGFCBLMAP2K5SH3GL2MAPK14STAT5ASH3BGRLPTK2BPTPN11STAT3EGFREPS15L1MAP3K4PRKCARGS16AKT1DUSP1MAP3K2PLD1STAT5BRAC1SOS2PIK3CAVAV2STAT2JUNZNF259ZNF259PRKCAPRKCZCASP9PXNPIK3R3SH2D3CCSKMAP3K14MAP3K2ARF4RBBP7MAPK3CEACAM1GAB1APPL1EGFRKRT8MYCKRT17EGFNCK1WASLKLF11GJA1MAP2K1TGIF1SRCSPRY2GRB10GAB1PIK3CGWNK1RPS6KA3RPS6KA5SH2D3CELK4STAT1EPS8ITCHPIK3CBEGFRHRASCEBPAMTA2NDUFA13REPS1PRKCB1PIK3R2PLCG2JUNDGIT1NCK2HIST3H3MAPK1BCAR1AP2A1SOCS1APPL2PIK3C2BSHOC2PTPN6HIP1MAP2K1PLEC1STAT1BCAR1HTTSOS1RFXANKCEBPBREPS2STAT2PRKD1TNIP1ABI1STAT3ATF1VAV1APPL1KRT7SH3GL3EEF1A1SMAD2PRKAR1AMAP2K2STAT3LOC459737SMAD3FOXO1ARAFMAPK7GRB2PIK3CDDUSP1EPN1ELK1SH3GL2STAT5ARPS6KA2EPS15MAP3K3PLCG2RASA1PLD2CBLCRPS6KA3VAV3PTPN12CAV2ASAP1USP6NLEPPK1STXBP1KRASJAK1MAPK1CBLBPTK6STXBP1RAF1RAF1MAP3K1NRASPLCG1ARF4EPS15GRB7PIK3R1ERRFI1ELF3KRT18GAB2DNM1APPL2SOCS3EGFRPRKCIEEF1A1SMAD2MAP2K7SNCACREB1PLD1JAK2SHC1CAV1PTPN6ARF4SPRY2FOXO1CDC42CRKLINPPL1


Description

The androgen receptor is a member of the nuclear receptor family of ligand activated transcription factors. These receptors bind to steroid hormones, thyroid hormone, retinoids and vitamin D among others, dimerize and bind to DNA. Its ligands include testosterone, dehydroepiandrosterone and androstenedione. Stimulation of the receptor activates the SMAD signaling module. Source: http://www.netpath.org/pathways?path_id=NetPath_4

Comments

GenMAPP notes 
NetPath 4; cellmap:4 - EGFR1 Signaling Pathway.This cancer signaling pathway is available at Cancer Cell Map (http://cancer.cellmap.org) and NetPath (http://www.netpath.org) and is part of a collaborative project between the Computational Biology Center at Memorial Sloan-Kettering Cancer Center (http://cbio.mskcc.org), PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the Cancer Cell Map and NetPath websites until the pathway is published.
GenMAPP remarks 
http://cancer.cellmap.org; http://www.netpath.org
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP437(r21600) with a 78% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

  1. Hornberg JJ, Binder B, Bruggeman FJ, Schoeberl B, Heinrich R, Westerhoff HV; ''Control of MAPK signalling: from complexity to what really matters.''; Oncogene, 2005 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
69215view18:32, 8 July 2013MaintBotUpdated to 2013 gpml schema
67180view10:17, 26 June 2013Christine ChichesterOntology Term : 'epidermal growth factor/neuregulin signaling pathway' added !
41517view01:56, 2 March 2011MaintBotRemoved redundant pathway information and comments
35720view23:29, 12 February 2010AlexanderPico
35436view11:33, 12 February 2010MichielAdded ref
34257view21:49, 9 December 2009MaintBotAutomatic update of empty xrefs
30429view21:18, 29 July 2009MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
ABI1GeneProduct450363 (Entrez Gene)
AKT1GeneProduct740898 (Entrez Gene)
AP2A1GeneProduct468956 (Entrez Gene)
APPL1GeneProduct460469 (Entrez Gene)
APPL2GeneProduct452197 (Entrez Gene)
ARAFGeneProduct
ARF4GeneProduct747376 (Entrez Gene)
ASAP1GeneProduct464399 (Entrez Gene)
ATF1GeneProduct452429 (Entrez Gene)
BCAR1GeneProduct454246 (Entrez Gene)
CAMK2AGeneProduct462189 (Entrez Gene)
CASP9GeneProduct456457 (Entrez Gene)
CAV1GeneProduct463670 (Entrez Gene)
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CBLBGeneProduct460566 (Entrez Gene)
CBLCGeneProduct
CDC42GeneProduct456609 (Entrez Gene)
CEACAM1GeneProduct
CEBPAGeneProduct
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CTNND1GeneProduct743685 (Entrez Gene)
DNM1GeneProduct464766 (Entrez Gene)
DOK2GeneProduct464036 (Entrez Gene)
DUSP1GeneProduct471742 (Entrez Gene)
EEF1A1GeneProduct494136 (Entrez Gene)
EGFGeneProduct461435 (Entrez Gene)
EGFRGeneProduct463415 (Entrez Gene)
ELF3GeneProduct739176 (Entrez Gene)
ELK1GeneProduct
ELK4GeneProduct742304 (Entrez Gene)
EPN1GeneProduct737301 (Entrez Gene)
EPPK1GeneProduct464453 (Entrez Gene)
EPS15GeneProduct456850 (Entrez Gene)
EPS15L1GeneProduct455810 (Entrez Gene)
EPS8GeneProduct473379 (Entrez Gene)
ERRFI1GeneProduct469787 (Entrez Gene)
FOSGeneProduct453047 (Entrez Gene)
FOXO1GeneProduct467352 (Entrez Gene)
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HIST3H3GeneProduct
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INPPL1GeneProduct451403 (Entrez Gene)
ITCHGeneProduct
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JUNDGeneProduct748667 (Entrez Gene)
KLF11GeneProduct459023 (Entrez Gene)
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KRT17GeneProduct468261 (Entrez Gene)
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PIK3CGGeneProduct463649 (Entrez Gene)
PIK3R1GeneProduct461836 (Entrez Gene)
PIK3R2GeneProduct455855 (Entrez Gene)
PIK3R3GeneProduct456565 (Entrez Gene)
PITPNAGeneProduct747193 (Entrez Gene)
PKN2GeneProduct456998 (Entrez Gene)
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PRKAR1AGeneProduct454845 (Entrez Gene)
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PRKCB1GeneProduct
PRKCGGeneProduct456276 (Entrez Gene)
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PRKCZGeneProduct743533 (Entrez Gene)
PRKD1GeneProduct452834 (Entrez Gene)
PTK2BGeneProduct464073 (Entrez Gene)
PTK6GeneProduct
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PXNGeneProduct452303 (Entrez Gene)
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RAC1GeneProduct
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REPS1GeneProduct463031 (Entrez Gene)
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RPS6KA1GeneProduct
RPS6KA2GeneProduct
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SH2D3CGeneProduct464753 (Entrez Gene)
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SH3GL2GeneProduct465008 (Entrez Gene)
SH3GL3GeneProduct453602 (Entrez Gene)
SH3KBP1GeneProduct465527 (Entrez Gene)
SHC1GeneProduct457351 (Entrez Gene)
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SIN3AGeneProduct453759 (Entrez Gene)
SMAD2GeneProduct455407 (Entrez Gene)
SMAD3GeneProduct748161 (Entrez Gene)
SNCAGeneProduct461375 (Entrez Gene)
SNRPD2GeneProduct456134 (Entrez Gene)
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STXBP1GeneProduct
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TNK2GeneProduct
USP6NLGeneProduct466011 (Entrez Gene)
VAV1GeneProduct455647 (Entrez Gene)
VAV2GeneProduct
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WASLGeneProduct463688 (Entrez Gene)
WNK1GeneProduct451739 (Entrez Gene)
YWHABGeneProduct
ZNF259GeneProduct741012 (Entrez Gene)

Annotated Interactions

No annotated interactions
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